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ZNS-wirksame Pharmaka bei Niereninsuffizienz

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Book cover Pharmakotherapie bei Niereninsuffizienz

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Zusammenfassung

In dieser Übersicht soll beschrieben werden, welche Veränderungen der Pharmakokinetik von Arzneimitteln, die auf das Zentralnervensystem (ZNS) wirken, beim Urämiker beobachtet werden. In dieser Gruppe werden Hypnotika, Neuroleptika, Antidepressiva, Antiepileptika und Lithium aufgeführt.

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Literatur

  1. Meyer MC, Guttman DE (1968) The binding of drugs by plasma proteins. J Pharm Sci 57:895–918

    Article  PubMed  CAS  Google Scholar 

  2. Shoeman DW, Azarnoff DL (1972) The alteration of plasma proteins in uremia as reflected in their ability to bind digitoxin and diphenyl-hydantoin. Pharmacology 7:169–177

    Article  PubMed  CAS  Google Scholar 

  3. Andreasen F (1973) Protein binding of drugs in plasma from patients with acute renal failure. Acta Pharmacol Toxicol 32:417–429

    Article  CAS  Google Scholar 

  4. Reidenberg MM, Odar-Cederlöf I, Bahr CML von, Borga O, Sjöqvist (1971) Protein binding of diphenylhydantoin and desimipramine in plasma from patients with poor renal function. New Engl J Med 285:264–267

    Article  PubMed  CAS  Google Scholar 

  5. Hooper WD, Bochner F, Eadie MJ, Tyrer JH (1974) Plasma protein binding of diphenylhydantoin. Effects of sex hormones, renal and hepatic disease. Clin Pharmacol Ther 15:276–282

    PubMed  CAS  Google Scholar 

  6. Odar-Cederlöf I, Borga O (1976) Impaired plasma protein binding of Phenytoin in uremia and displacement effect of salicylic acid. Clin Pharmacol Ther 20:36–47

    PubMed  Google Scholar 

  7. Bennett WM, Singer I, Golper T, Feig P, Coggins CJ (1977) Guidelines for drug therapy in renal failure. Ann Intern Med 86:754–783

    PubMed  CAS  Google Scholar 

  8. Reidenberg MM, Lowenthal DT, Briggs W, Gasparo M (1976) Pentobarbital elimination in patients with poor renal function. Clin Pharmacol Ther 20:67–71

    PubMed  CAS  Google Scholar 

  9. Kleijn E van der, Vree I, Guelen P, Schobten F, Westenberg H, Knop H (1978) Kinetics of drug interactions in the treatment of epilepsy. Int J Clin Pharmacol Biopharm 16:467–473

    PubMed  Google Scholar 

  10. Dundee JW, Richards RK (1954) Effect of azotemia upon the action of intravenous barbiturate anesthesia. Anesthesiology 15:333–346

    Article  PubMed  CAS  Google Scholar 

  11. Ghoneim MM, Pandya H (1975) Plasma protein binding of thiopental in patients with impaired renal or hepatic function. Anesthesiology 42:545–549

    Article  PubMed  CAS  Google Scholar 

  12. Richards RK, Taylor JD, Kneter KE (1953) Effect of nephrectomy on duration of sleep following administration of thiopental and hexo-barbital. J Pharmacol Exp Ther 108:461–463

    PubMed  CAS  Google Scholar 

  13. Taylor JD, Richards RK, Darin JC (1954) Plasma binding of thiopental in the nephrectomized rabbit. J Pharmacol Exp Ther 112:40–48

    PubMed  CAS  Google Scholar 

  14. Maher JF (1970) Determinants of serum half-life of glutethimide in intoxicated patients. J Pharmacol Exp Ther 174:450–455

    PubMed  CAS  Google Scholar 

  15. Maher JF, Schreiner GE, Westervelt FB, Jr. (1962) Acute glutethimide intoxication. Am J Med 33:70–82

    Article  PubMed  CAS  Google Scholar 

  16. Dasberg HH, Kleijn E van der, Guelen P, Praag HM van (1974) Plasma concentrations of diazepam and of its metabolite N-desmethyl-diazepam in relation to anxiolytic effect. Clin Pharmacol Ther 15:473–483

    PubMed  CAS  Google Scholar 

  17. Klitz U, Avant GR, Hoyumpa A (1975) The effects of age and liver disease on the disposition and elimination of diazepam in adult man. J Clin Invest 55:347–359

    Article  Google Scholar 

  18. Sellman R, Kanto J, Pekkarinen J (1975) Biliary excretion of diazepam and its metabolites in man. Acta Pharmacol Toxicol 37:242–249

    Article  CAS  Google Scholar 

  19. Koechlin BA, Schwartz MA, Krol G, Oberhansli W (1965) The metabolic fate of 14C-labeled chlordiazepoxide in man, in the dog, and in the rat. J Pharmacol Exp Ther 148:399–411

    PubMed  CAS  Google Scholar 

  20. Kangas L, Kanto J, Forsström J, Iisalo E (1976) The protein binding of diazepam and N-methyldiazepam in patients with poor renal function. Clin Nephrol 5:114–118

    PubMed  CAS  Google Scholar 

  21. Dahl SG (1976) Pharmacokinetics of methotrimeprazine after single and multiple doses. Clin Pharmacol Ther 19:435–442

    PubMed  CAS  Google Scholar 

  22. Sjöqvist F, Bergund F, Borga O, Hammer W, Andersson S, Thorstrand C (1969) The pH-dependent excretion of monomethyllated tricyclic antidepressants. Clin Pharmacol Ther 10:826–833

    PubMed  Google Scholar 

  23. Spiker DG, Weiss AN, Chang SS, Ruwitch JF, Jr., Briggs JT (1975) Tricyclic antidepressant overdose: clinical presentation and plasma levels. Clin Pharmacol Ther 18:539–546

    PubMed  CAS  Google Scholar 

  24. Kaspar U (1976) Diphenylhydantoin, Metabolismus, Wirkungsweise, Interaktionen und Nebenwirkungen. Schweiz Med Wochenschr 106:777–788

    PubMed  CAS  Google Scholar 

  25. Lund L, Berlin A, Lunde PKM (1972) Plasma protein binding of diphenylhydantoin in patients with epilepsy. Clin Pharmacol Ther 13:196–204

    PubMed  CAS  Google Scholar 

  26. Noach EL, Woodbury DM, Goodmann LS (1958) Studies on the absorption, distribution, fate and excretion of A-14C-labeled diphenylhydantoin. J Pharmacol Exp Ther 122:301–314

    PubMed  CAS  Google Scholar 

  27. Glazko AG, Chang T, Bankema J, Dill WA, Goulet JR, Buchanan RA (1969) Metabolic disposition of diphenylhydantoin in normal human subjects following intravenous administration. Clin Pharmacol Ther 10:498–504

    PubMed  CAS  Google Scholar 

  28. Schmidt D, Vogel A (1977) Plasmakonzentrationen nach Injektion und Infusion von Phenytoin. Klin Wochenschr 55:219–223

    Article  PubMed  CAS  Google Scholar 

  29. Letteri JM, Mellke H, Lonis S, Kutt H, Durante P, Glazko A (1971) Diphenylhydantoin metabolism in uremia. XI Engl J Med 285:648–652

    CAS  Google Scholar 

  30. Lunde PKM, Rane A, Yaffe SJ, Lund L, Sjöqvist F (1970) Plasma protein binding of diphenylhydantoin in man. Clin Pharmacol Ther 2:846–855

    Google Scholar 

  31. Mullen PW.(1978) Optimal phenytoin therapy. A new technique for individualizing dosage. Clin Pharmacol Ther 23:228–232

    PubMed  CAS  Google Scholar 

  32. Furlanut M, Benetello P, Avogaro A, Dainese R (1978) Effects of folic acid on phenytoin kinetics in healthy subjects. Clin Pharmacol Ther 24:294–297

    PubMed  CAS  Google Scholar 

  33. Ludden TM, Allen JP, Valutsky WA, Vicuna AV, Nappi JM, Hoffman SF, Wallace JE, Lalka D, McNay JL (1977) Individualization of phenytoin dosage regimens. Clin Pharmacol Ther 21:287–293

    PubMed  CAS  Google Scholar 

  34. Cook CE, Amerson E, Poole WK, Lesser P, O’tuama L (1975) Phenytoin and phenobarbital concentrations in saliva and plasma measured by radio-immuno-assay. Clin Pharmacol Ther 18:752–747

    Google Scholar 

  35. Ananvekar SN, Saunders RH, Wardell WM, Shoulson I, Emmings FG, Cook CE, Gringeri AJ (1978) Parotid and whole saliva in the prediction of serum total and free phenytoin concentrations. Clin Pharmacol Ther 24:629–637

    Google Scholar 

  36. The Boston Collaborative Drug Surveillance Program (1973) Diphenylhydantoin side effect and serum albumin levels. Clin Pharmacol Ther 14:529–532

    Google Scholar 

  37. Lai AA, Levy RH, Cutler RE (1978) Time course of interaction between carbamazepine and clonazepam in normal man. Clin Pharmacol Ther 24:316–323

    PubMed  CAS  Google Scholar 

  38. Cerghino JJ, Brock JT, Meter JC van, Penry JK, Smith LD, White B (1975) The efficacy of carbamazepine combinations in epilepsy. Clin Pharmacol Ther 18:733–741

    Google Scholar 

  39. Thomsen K, Schou M (1968) Renal lithium excretion in man. Am J Physiol 215:823–827

    PubMed  CAS  Google Scholar 

  40. Hollister LE (1978) Clinical pharmacology of psychotherapeutic drugs. In: Monographs in clinical pharmacology, vol 1. Livingstone, New York Edinburgh London pp 192–226

    Google Scholar 

  41. White MG, Fetner CD (1975) Treatment of the syndrome of inappropriate secretion of antidiuretic hormone with lithium carbonate. New Engl J Med 292:390–392

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Aachen, Deutschland

    H. Oßwald

Authors
  1. H. Oßwald
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Editor information

Editors and Affiliations

  1. Abt. der Med., Univ.-Klinik, Luitpold Krankenhaus, Josef-Schneider-Str. 2, D-8700, Würzburg, Deutschland

    August Heidland (Leiter der Nophrolog) (Leiter der Nophrolog)

  2. Abt. I des Städt, Krankenhauses Rosenheim, Pettenkofertr. 10, D-8200, Rosenheim, Deutschland

    Egon Wetzels (Chefarzt der Med.) (Chefarzt der Med.)

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© 1980 Springer-Verlag Berlin Heidelberg

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Oßwald, H. (1980). ZNS-wirksame Pharmaka bei Niereninsuffizienz. In: Heidland, A., Wetzels, E. (eds) Pharmakotherapie bei Niereninsuffizienz. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67676-5_5

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  • DOI: https://doi.org/10.1007/978-3-642-67676-5_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10101-7

  • Online ISBN: 978-3-642-67676-5

  • eBook Packages: Springer Book Archive

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