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Medikamentöse Schäden der Niere

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Pharmakotherapie bei Niereninsuffizienz

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Zusammenfassung

Medikamente passieren die Niere in einer Sequenz unidirektio-naler (Filtration) und gegenläufiger Transportprozesse (tubuläre Reabsorption und Sekretion), Richtung und Ablauf dieses Stofftransports werden allerdings durch die pharmakologische Struktur der Einzelsubstanz näher bestimmt. Meist haben Medikamente ein niedriges Molekulargewicht (< 500) und werden — dissoziiert oder undissoziiert und abhängig von ihrer Proteinbindung — filtriert. Wasserlösliche Stoffe und Ionen werden aktiv reabsorbiert (z.B. Aminosäuren) oder mit dem Harn direkt ausgeschieden; lipoidlösliche Stoffe dagegen gelangen durch sie sog. nonionic diffusion ins peritubuläre Plasma zurück und werden erst durch die hepatische Biotransformation als polarere Substanzen nierengängig.

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  1. Würzburg, Deutschland

    E. Heidbreder & A. Heidland

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  1. E. Heidbreder
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  2. A. Heidland
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  1. Abt. der Med., Univ.-Klinik, Luitpold Krankenhaus, Josef-Schneider-Str. 2, D-8700, Würzburg, Deutschland

    August Heidland (Leiter der Nophrolog) (Leiter der Nophrolog)

  2. Abt. I des Städt, Krankenhauses Rosenheim, Pettenkofertr. 10, D-8200, Rosenheim, Deutschland

    Egon Wetzels (Chefarzt der Med.) (Chefarzt der Med.)

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Heidbreder, E., Heidland, A. (1980). Medikamentöse Schäden der Niere. In: Heidland, A., Wetzels, E. (eds) Pharmakotherapie bei Niereninsuffizienz. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67676-5_13

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  • DOI: https://doi.org/10.1007/978-3-642-67676-5_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10101-7

  • Online ISBN: 978-3-642-67676-5

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