Morphological Evaluation (Histologic, Histochemical, and Ultrastructural) of Endomyocardial Biopsies

  • E. G. J. Olsen


This paper, by way of introduction to the meeting, will concentrate on the morphological features of the various types of cardiomyopathies according to Goodwin’s 1975 classification (congestive, hypertrophic, with or without obstruction, oblitera-tive/restrictive). The morphological features of cardiomyopathies are well recognised and have been defined on material removed at surgical operation by van Noorden et al. (1971) or at post mortem by Olsen (1972, 1973a). These morphological criteria have been strictly applied to the tissue obtained by bioptome technique. They will be briefly summarised.


Hypertrophic Cardiomyopathy Endomyocardial Biopsy Irregular Arrangement Congestive Cardiomyopathy Endomyocardial Fibrosis 
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  1. 1.
    Boite H-D (1975) Immunologic investigation in patients with cardiomyopathies. In: Kaltenbach M, Loogen F, Olsen EGJ (eds) Cardiomyopathy and myocardial biopsy. Berlin Heidelberg New York, Springer, p 251Google Scholar
  2. 2.
    Brockington IF, Olsen EGJ (1973) Loffler’s endocarditis and Davies’ endomyocardial fibrosis. Am Heart J 85:308–322CrossRefGoogle Scholar
  3. 3.
    Bulkley BH, Weisfeldt ML, Hutchins GM (1977) Asymmetric septal hypertrophy and myocard1ial fiber disarray. Features of normal, developing and malformed hearts. Circulation 56:292–298PubMedGoogle Scholar
  4. 4.
    Dingemans KP, Becker AE (1977) Specificity of cellular and myofibrillar disorientation in hypertrophic obstructive cardiomyopathy. Arch Pathol Lab Med 101:493–499PubMedGoogle Scholar
  5. 5.
    Eckner FAO, Thaemert JC, Moulder PV, Blackstone EH (1967) Myocardial biopsy in dogs. Circulation 36:964–974PubMedGoogle Scholar
  6. 6.
    Edwards WD, Zakheim R, Mattiolo L (1977) Asymmetric septal hypertrophy in childhood. Unreliability of histologic criteria for differentiation of obstructive and nonobstructive forms. Hum Pathol 8:277–284PubMedCrossRefGoogle Scholar
  7. 7.
    Goodwin JF (1975) Myocardial diseases. Medicine, 2nd series. 25:1286–1296Google Scholar
  8. 8.
    Konno S, Sakakibara S (1963) Endomyocardial biopsy. Dis of the Chest 44:345–350CrossRefGoogle Scholar
  9. 9.
    Kuhn H, Breithardt G, Knieriem H-J, Loogen F, Both A, Schmidt WAK, Stroo-bandt R, Gleichmann U (1975) Die Bedeutung der endomyokardialen Katheter-biopsie für die Diagnostik und die Beurteilung der Prognose der kongestiven Kardiomyopathie. Dtsch Med Wochenschr 100:717–723PubMedCrossRefGoogle Scholar
  10. 10.
    MacArthur CGC, Cambridge G, Waterson AP, Goodwin JF, Oakley CM (1978) Antibodies to Coxsackie B viruses in primary congestive cardiomyopathy. (Abstract). Br Heart J 40:456Google Scholar
  11. 11.
    Maron BJ, Ferrans VJ, Henry WL, Clark CE, Redwood DR, Roberts WC, Morrow AG, Epstein SE (1974) Differences in distribution of myocardial abnormalities in patients with obstructive and non-obstructive asymmetric septal hypertrophy (ASH): light and electronmicroscopic findings. Circulation 50:346–446Google Scholar
  12. 12.
    Maron BJ, Ferrans VJ, Roberts WC (1975) Ultrastructural features of degenerated cardiac muscle cells in patients with cardiac hypertrophy. Am J Path 79:387–434PubMedGoogle Scholar
  13. 13.
    Noorden van S, Olsen EGJ, Pearse AGE (1971) Hypertrophic obstructive cardiomyopathy, a histological, histochemical and ultrastructural study of biopsy material. Cardiovasc Res V:118–131CrossRefGoogle Scholar
  14. 14.
    Oakley CM, Olsen EGJ (1977) Eosinophils and heart disease. Br Heart J 39:233–237PubMedCrossRefGoogle Scholar
  15. 15.
    Olsen EGJ (1971) Marbid anatomy and histology. In: Wolstenholme GEW, O’Connor M (eds) Ciba Foundation Study Group. No 37. J & A Churchill, London, pp 183–191Google Scholar
  16. 16.
    Olsen EGJ (1972) Cardiomyopathies. In: Edwards JE, Brest AW (eds) Clinical-pathologic correlations 1. Cardiovascular Clinics. Davis, Philadelphia, 4:pp 240–261Google Scholar
  17. 17.
    Olsen EGJ (1973a) The pathology of the heart. Intercontinental Medical Book, New York, p 171Google Scholar
  18. Olsen EGJ (1973b) The pathology of the heart. Intercontinental Medical Books, New York, p 26Google Scholar
  19. 18.
    Olsen EGJ (1974) Diagnostic value of the endomyocardial bioptome. Lancet I:658–660CrossRefGoogle Scholar
  20. 19.
    Olsen EGJ (1975) Pathological recognition of cardiomyopathy. Postgrad Med J 51:277–281PubMedCrossRefGoogle Scholar
  21. 20.
    Olsen EGJ (1976) Pathologie der,primären’ Kardiomyopathien. Münch Med Wo-chenschr 118:735–740Google Scholar
  22. 21.
    Olsen EGJ (1977) Myocardial biopsies. In: Hamer J (ed) Recent advances in cardiology. Churchill Livingstone, Edinburgh London, p 349Google Scholar
  23. 22.
    Olsen EGJ (1978a) Endomyocardial biopsy. Invest Cell Pathol 1:139–157PubMedGoogle Scholar
  24. 23.
    Olsen EGJ (1978b) Endomyocardial biopsy. (Editorial) Br Heart J 40:95–98PubMedCrossRefGoogle Scholar
  25. 24.
    Peters TJ, Wells G, Oakley CM, Brooksby IAB, Jenkins BS, WebbPeploe MM, Col-tart DJ (1977) Enzymatic analysis of endomyocardial biopsy specimens from patients with cardiomyopathies. Br Heart J 39:1333–1339PubMedCrossRefGoogle Scholar
  26. 25.
    Richardson PJ (1974) King’s endomyocardial bioptome. Lancet 1:660–661PubMedCrossRefGoogle Scholar
  27. 26.
    Sakakibara S, Konno S (1962) Endomyocardial biopsy. Jpn Heart J 3:537–543PubMedCrossRefGoogle Scholar
  28. 27.
    Sekeguchi M, Konno S, Hasegawa F, Hirosawa K (1972/73) Some characteristic electron microscopic pictures of diseased myocardium obtained by endomyocardial biopsy. Bull Heart Instit Japan 14:30–52Google Scholar
  29. 28.
    Somers K, Hutt MSR, Patel AK, D’Arbela PG (1971) Endomyocardial biopsy in diagnosis of cardiomyopathies. Br Heart J 33:822–832PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • E. G. J. Olsen
    • 1
  1. 1.LondonUK

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