Skip to main content
SpringerLink
Log in

Effects of Stimulation of Chemosensitive Areas by Superfusion on Ventral Medulla and by Infusion into Vertebral Artery of Chemical Stimuli in Non-Anaesthetized “Encéphale Isolé” Preparations in Cats

  • Conference paper
Book cover Central Interaction Between Respiratory and Cardiovascular Control Systems

Abstract

Since the discovery of the chemosensitive areas on the ventral surface of the medulla (1 – 4), their functional role has been explored further than the chemical control of respiration as a possible site of central interaction between respiratory and cardiovascular control system. Trzebski et al. (5 – 7) found that low pH artificial cerebrospinal fluid (CSF) superfused over the ventral medulla produced an increase of the spontaneous activity in the sympathetic nerves, together with pressor responses. A fall of arterial blood pressure has been observed after local application to the surface of ventral medulla of pentobarbitone (8), glycine, γ-aminobutyric acid, cholinomimetic drugs (9, 10), Clonidine (11), and nicotine (12).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Loeschcke HH, Koepchen HP (1958) Versuch zur Lokalisation des Angriffsortes der Atmungs- und KreislaufWirkung von Novocain im Liquor cerebrospinalis. Pfluegers Arch 266:628–639

    Article  CAS  Google Scholar 

  2. Mitchell RA, Loeschcke HH, Severinghaus JW, Richardson BW, Massion WH (1963) Regions of respiratory chemosensitivity on the surface of the medulla. Ann NY Acad Sci 109:661–681

    Article  Google Scholar 

  3. Loeschcke HH, Lattre J de, Schlafke ME, Trouth CO (1970) Effects on respiration and circulation of electrically stimulating the ventral surface of the medulla oblongata. Respir Physiol 10:184–197

    Article  PubMed  CAS  Google Scholar 

  4. Schläfke ME, See WR, Loeschcke HH (1970) Ventilatory response to alterations of H+ ion concentration in small areas of the ventral medullary surface. Respir Physiol 10:198–212

    Article  Google Scholar 

  5. Trzebski A, Zielinski A, Lipski J, Majcherczyk S (1971) Increase of sympathetic preganglionic discharges and of the peripheral resistance following stimulation by H+ ions of the superficial chemosensitive areas in the medulla oblongata in cats. Proc Intern Union Physiol Sci, vol 9 (abstr 1701), p 571

    Google Scholar 

  6. Trzebski A, Zielinski A, Majcherczyk S, Lipski J, Szulczyk P (1974) Effect of chemical stimulation and depression of the medullary superficial areas on the respiratory motoneurones discharges, sympathetic activity and efferent control of carotid area receptors. In: Umbach W, Koepchen HP (eds) Central rhythmic and regulation. Hippokrates, Stuttgart, pp 170–174

    Google Scholar 

  7. Trzebski A, Majcherczyk S, Szulczyk P, Chruêcielewski L (1976) Direct nervous mechanism as the possible pathways of interaction of the central and peripheral chemosensitive areas. In: Loeschcke HH (ed) Acid base homeostasis of the brain extracellular fluid and the respiratory control system. Georg Thieme, Stuttgart, pp 130–145

    Google Scholar 

  8. Feldberg W, Guertzenstein PG (1972) A vasodepressor effect of pentobarbitone sodium. J Physiol (Lond) 224:83–103

    CAS  Google Scholar 

  9. Guertzenstein PG (1973) Blood pressure effects obtained by drugs applied to the ventral surface of the brain stem. J Physiol (Lond) 229:395–408

    CAS  Google Scholar 

  10. Guertzenstein PG, Silver A (1974) Fall in blood pressure produced from discrete regions of the ventral surface of the medulla by glycine and lesions. J Physiol (Lond) 242:489–503

    CAS  Google Scholar 

  11. Bousquet P, Feldman J, Velly J, Block R (1975) Role of the ventral surface of the brain in the hypotensive action of Clonidine. Eur J Pharmacol 34:151–156

    Article  PubMed  CAS  Google Scholar 

  12. Feldberg W, Guertzenstein PG (1976) Vasodepressor effects obtained by drugs acting on the ventral surface of the brain stem. J Physiol (Lond) 258:337–355

    CAS  Google Scholar 

  13. Feldberg W (1976) The ventral surface of the brain stem: A scarely explored region of pharmacological sensitivity. Neuroscience 1:427–441

    Article  PubMed  CAS  Google Scholar 

  14. Trzebski A, Mikulski A, Przybyszewski A (1977) Influence of the chemosensitive areas on the ventral surface of the medulla oblongata on the EEG activity in encéphale isolé preparations in cats. Proc Intern Union Physiol Sci, vol 13 (abstr 2274), p 764 (1977)

    Google Scholar 

  15. Berndt J, Berger W, Trouth CO (1970) Respiratory and circulatory effects of 100 meq/l potassium or 2% procaine in the cerebrospinal fluid of cats. Pfluegers Arch 321:346–363

    Article  CAS  Google Scholar 

  16. Berndt J, Berger W, Berger K, Schmidt M (1972) Untersuchungen zum zentralen chemosensiblen Mechanismus der Atmung. Pfluegers Arch 146:332–346

    Google Scholar 

  17. Trouth CO, Loeschcke HH, Berndt J (1973) A superficial substrate on the ventral surface of the medulla oblongata influencing respiration. Pfluegers Arch 339: 135–152

    Article  CAS  Google Scholar 

  18. Schläfke ME, Hukuhara T Jr, See WR (1976) Neuronal activity within the ventral medullary surface layer (intermediate area) during electrical stimulation of sinus nerve afférents and changes of pH in blood. Pfluegers Arch (suppl) 365: R39

    Google Scholar 

  19. Loeschcke HH, Mitchell RA (1963) Properties and localisation of intracranial chemosensitivity. In: Cunningham DJC, Lloyd BB (eds) Regulation of human respiration. Blackwell, Oxford, pp 243–256

    Google Scholar 

  20. Lipscomb WT, Boyarsky LL (1972) Neurophysiological investigations of medullary chemosensitive areas of respiration. Respir Physiol 16:362–376

    Article  PubMed  CAS  Google Scholar 

  21. Hukuhara T Jr, See WR, Fritsche P, Schläfke ME (1976) Respiratory drives and the ascending reticular activating system. Pfluegers Arch (suppl) 365:R39

    Google Scholar 

  22. Magnus J, Moruzzi G, Pompeiano O (1961) Synchronization of the EEG produced by low frequency stimulation of the region of the solitary tract. Arch Ital Biol 99:33–43

    Google Scholar 

  23. Katona PG, Lipson D, Dauchot J (1977) Opposing central and peripheral effects of atropine on parasympathetic cardiac control. Am J Physiol 232:11146–151

    Google Scholar 

  24. Dev NB, Loeschcke HH (1976) Effects on respiration and circulation of nicotine and acetylcholine applied to the ventral surface of the medulla oblongata of the cat. Pfluegers Arch (suppl) 365:R39

    Google Scholar 

  25. Duggan AW, Game CJA (1975) The sensitivity of paramedian reticular neurones to acetylcholine. J Physiol (Lond) 247:25–36

    CAS  Google Scholar 

  26. Miura M, Reis DJ (1971) The paramedian reticular nucleus: A site of inhibitory interaction between projections from fastigial nucleus and carotid sinus nerve acting on blood pressure. J Physiol (Lond) 216:441–460

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiology, Warsaw Medical Academy, Krakowskie Przedmiéscie 26/28, 00-927, Warsaw, Poland

    A. Trzebski, A. Mikulski & A. Przybyszewski

Authors
  1. A. Trzebski
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Mikulski
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Przybyszewski
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut für Physiologie, Freie Universität Berlin, Arnimallee 22, D-1000, Berlin 33, Germany

    H. P. Koepchen

  2. Department of Physiology, The Medical School, The University of Birmingham, Vincent Drive, B15 2TJ, GB Birmingham, UK

    S. M. Hilton

  3. Katedra i Zaklad Fizjologii ul. Krakowskie, Akademia Medyczna w Warszawie, Przedmiescie 26/28, P-Warschau, Poland

    A. Trzebski

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Trzebski, A., Mikulski, A., Przybyszewski, A. (1980). Effects of Stimulation of Chemosensitive Areas by Superfusion on Ventral Medulla and by Infusion into Vertebral Artery of Chemical Stimuli in Non-Anaesthetized “Encéphale Isolé” Preparations in Cats. In: Koepchen, H.P., Hilton, S.M., Trzebski, A. (eds) Central Interaction Between Respiratory and Cardiovascular Control Systems. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67603-1_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-67603-1_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-09948-2

  • Online ISBN: 978-3-642-67603-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation