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Ventral Medullary Surface Stimulus Response in Relation to Ventilatory and Cardiovascular Effects

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Central Interaction Between Respiratory and Cardiovascular Control Systems

Abstract

Loeschcke et al. (1) and Mitchell et al. (2) revealed chemical sensitivity of the ventrolateral medullary surface and put forward the hypothesis that this is the sensor site of central chemosensitivity in relation to respiratory control. Local electrical stimulation on the ventral medullary surface elicits both respiratory and cardiovascular effects (3) (Fig. 1). Ventilatory responses were observed when small areas on the ventral surface were locally stimulated by the application of artificial cerebrospinal fluid with a pK below 7.4. No significant blood pressure effects were produced by this method (4). Between the rostral and the caudal group of points from which respiratory and arterial pressure responses could be produced, bilateral cold block of the “intermediate area” (area S) inhibited ventilation and lowered arterial pressure. This effect was much more pronounced with peripheral chemoreceptors eliminated, then causing complete apnoea.

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Author information

Authors and Affiliations

  1. Institute of Physiology, Ruhr-Universität Bochum, Universitätsstraße 150, D-4630, Bochum, Germany

    Marianne E. Schläfke & W. R. See

Authors
  1. Marianne E. Schläfke
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  2. W. R. See
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Editor information

Editors and Affiliations

  1. Institut für Physiologie, Freie Universität Berlin, Arnimallee 22, D-1000, Berlin 33, Germany

    H. P. Koepchen

  2. Department of Physiology, The Medical School, The University of Birmingham, Vincent Drive, B15 2TJ, GB Birmingham, UK

    S. M. Hilton

  3. Katedra i Zaklad Fizjologii ul. Krakowskie, Akademia Medyczna w Warszawie, Przedmiescie 26/28, P-Warschau, Poland

    A. Trzebski

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© 1980 Springer-Verlag Berlin Heidelberg

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Schläfke, M.E., See, W.R. (1980). Ventral Medullary Surface Stimulus Response in Relation to Ventilatory and Cardiovascular Effects. In: Koepchen, H.P., Hilton, S.M., Trzebski, A. (eds) Central Interaction Between Respiratory and Cardiovascular Control Systems. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67603-1_7

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  • DOI: https://doi.org/10.1007/978-3-642-67603-1_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-09948-2

  • Online ISBN: 978-3-642-67603-1

  • eBook Packages: Springer Book Archive

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