Central Modulation of Inspiratory and Expiratory Stimulations of the Carotid Body and Carotid Sinus Nerve
In the past few years it has become apparent that the afferent input from peripheral nerves does not act on the central neural respiratory controller in a simple proportional manner. In the case of peripheral chemoreceptors and nerves the respiratory response appears to depend not only on the characteristics of the source but also on the time in the respiratory cycle that the stimulus occurs (1–8). This finding has several important implications: (a) Since the chemical signal at the carotid body is varying in an oscillating manner, the timing of the peak of that oscillation with relation to the respiratory cycle could be an important variable affecting respiratory output, (b) it suggests that carotid body signals are not well “stored and remembered” in the central control system and thus has implications for the understanding of its organization.
KeywordsCarotid Body Respiratory Cycle Carotid Sinus Nerve Inspiratory Neurone Phrenic Nerve Activity
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