Abstract
Myocardial infarction represents a highly likely source of reentrant ventricular arrhythmias. Although most studies of the early phase of ventricular arrhythmias that follow acute ligation of a major coronary artery in the dog have shown some of the basic prerequisites for reentry in the form of desynchronized slow conduction in ischemic myocardium (1–8), they all fall short of actually documenting the presence of reentry. This was due, we believe, to the highly dynamic situation following acute ligation of a major coronary artery with constantly changing electrophysiologic properties in the ischemic zone. Thus, it is difficult to conduct systematic electrophysiologic studies of the possible reentrant mechanism under such dynamic conditions. In addition, the recording techniques usually failed to demonstrate the one unequivocal evidence for reentry, namely, the presence of continuous electric activity originating from the infarction zone that regularly and predictably bridge the diastolic interval between the reentrant beat and the preceding impulse, as well as between consecutive reentrant beats, (9).
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References
Gambetta M, Childers RW (1969) The initial electrophysiologic disturbance in experimental myocardial infarction. (Abstract) Ann Intern Med 71: 1076
Han J (1969) Mechanisms of ventricular arrhythmias associated with myocardial infarction. Am J Cardiol 24: 800
Durrer D, Van Dam RTH, Freud GE, Janse MJ (1971) Re-entry and ventricular arrhythmias in local ischemia and infarction of the intact dog heart. Proc K Ned Akad Wet C73 /4
Waldo AL, Kaiser GA (1973) A study of ventricular arrhythmias associated with acute myocardial infarction in the canine heart. Circulation 47: 1222
Boineau JP, Cox JL (1973) Slow ventricular activation in acute myocardial infarction. A source of reentrant premature ventricular contractions. Circulation 48: 702
Scherlag BJ, El-Sherif N, Hope R, Lazzara R (1974) Characterization and localization of ventricular arrhythmias due to myocardial ischemia and infarction. Circ Res 35: 372
Williams DO, Scherlag BJ, Hope R, El-Sherif N, Lazzara R (1974) The pathophysiology of malignant ventricular arrhythmias during acute myocardial ischemia. Cir-culation 50: 1163
El-Sherif N, Scherlag BJ, Lazzara R (1975) Electrode catheter recordings during malignant ventricular arrhythmias following experimental acute myocardial ischemia. Circulation 51: 1003
El-Sherif N, Scherlag BJ, Lazzara R, Hope RR (1977) Reentrant ventricular arrhythmias in the late myocardial period. 1. Conduction characteristics in the infarction zone. Circulation 55: 686
El-Sherif N, Hope RR, Scherlag BJ, Lazzara R (1977) Reentrant ventricular arrhythmias in the late myocardial infarction period. 2. Pattern of initiation and termination of reentry. Circulation 55: 702
El-Sherif N, Lazzara R, Hope RR, Scherlag BJ (1977) Reentrant ventricular arrhythmias in the late myocardial infarction period. 3. Manifest and concealed extra- systolic grouping. Circulation 56: 225
El-Sherif N, Scherlag BJ, Lazzara R, Hope RR (1977) Reentrant ventricular arrhythmias in the late myocardial infarction period. 4. Mechanism of action of lidocaine. Circulation 56: 395
El-Sherif N, Lazzara R (1978) Reentrant ventricular arrhythmias in the late myocardial infarction period. 5. Mechanism of action of diphenhylhydantoin. Circulation 57: 405
El-Sherif N (1978) Reentrant ventricular arrhythmias in the late myocardial infarction period. 6. Effect of the autonomic system. Circulation 58: 103
El-Sherif N, Lazzara R (1979) Reentrant ventricular arrhythmias in the late myocardial infarction period. 7. Effect of verapamil and D-600 and role of the “slow channel”. Circulation 60: 605
Lazzara R, Hope RR, El-Sherif N, Scherlag BJ (1978) Effects of lidocaine on hypoxic and ischemic cardiac cells. Am J Cardiol 41: 872
Smith RA, El-Sherif N, Evans AK (1978) Epicardial mapping of ventricular reentrant pathways in the late myocardial infarction period. (Abstract) Am J Cardiol 41: 427
Edwards JE (1969) What is myocarcial infarction? Circulation [Supp. IV]: 39, 40 IV - 5
Schmitt FO, Erlanger J (1928) Directional differences in the conduction of the impulse through heart muscle and their possible relation to extrasystolic and fibrillary contractions. Am J Physiol 87: 326
Schamroth L, Marriott HJL (1963) Concealed ventricular extrasystoles. Circulation 27: 1043
Schamroth L (1971) The physiological basis of ectopic ventricular rhythm: A uni-fying concept. S Afr Med J [Suppl] 3
El-Sherif N, Scherlag BJ, Lazzara R, Samet P (1974) Pathophysiology of tachycardia and bradycardia-dependent block in the canine proximal His Purkinje system after acute ischemia. Am J Cardiol 33: 529
Lazzara R, El-Sherif N, Scherlag BJ (1975) Disorders of cellular electrophysiology produced by ischemia of the canine His bundle. Circ Res 36: 444
Lazzara R, El-Sherif N, Hope RR, Scherlag BJ (1978) Ventricular arrhythmias and electrophysiologic consequences of ischemia and infarction. Circ Res 42: 740
Cranefield PF, Klein HO, Hoffman BF (1971) Conduction of the cardiac impulse: 1. Delay, blocks and one-way block in depressed Purkinje fibers. Circ Res 28: 199
Cranefield PF, Wit AL, Hoffman BF (1972) Conduction of the cardiac impulse. III. Characteristics of very slow conduction. J Gen Physiol 59: 227
Cranefield PF (1975) The Conduction of the Cardiac Impulse. Futura, Mount Kisco New York
Carmaliet E, Vereeke S (1969) Adrenaline and the plateau phase of the cardiac action potential: Importance of Ca++, Na+, and K+ conductance. Pfluegers Arch 313: 300
Pappano AJ (1970) Calcium-dependent action potentials produced by catecholamines in guinea pig atrial muscle fibers depolarized by potassium. Circ Res 27: 379
Shigenobu K, Sperelakis N (1972) Calcium current channels induced by catechol-amines in chick embryonic hearts whose fast sodium channels are blocked by tetrodotoxin or elevated potassium. Circ Res 932
Wit AL, Hoffman BF, Cranefield PF (1972) Slow conduction and reentry in the ventricular conducting system. Return extrasystole in canine Purkinje fibers. Circ Res 30: 1
Shigenobu K, Schneider JA, Sperelakis N (1974) Verapamil blockade of slow Na and Ca++ reSponses in myocardial cells. J Pharmacol Exp Ther 190: 280
Wit AL, Bigger JT Jr (1975) Possible electrophysiological mechanisms for lethal arrhythmias accompanying myocardial ischemia and infarction. Circulation [Suppl 3] 51: 96
Thomas M, Shulman G, Opie L (1970) Arteriovenous potassium changes and ventricular arrhythmias after coronary artery occlusion. Cardiovasc Res 4: 327
Cherry G, Myers MB (1971) The relationship to ventricular fibrillation of early tissue sodiums and potassium shifts and coronary vein potassium levels in experimental myocardial infarction. J Thorac Cardiovasc Surg 61: 587
Griffith J, Leung F (1971) The sequential estimation of plasma catecholamines and whole blood histamine in myocardial infarction. Am Heart J 82: 171
Downar E, Janse MJ, Durrer D (1977) The effect of ischemic blood on transmembrane potentials of normal porcine ventricular myocardium. Circulation 55: 455
Kuppersmith J, Shiang H, Litwak RS, Herman MV (1976) Electrophysiologic effects of verapamil in canine myocardial ischemia. Am J Cardiol 37: 149 (Abstract)
Elharrar J, Guam WE, Zipes DP (1977) Effect of drugs on conduction delay and incidence of ventricular arrhythmias induced by acute coronary occlusion in dogs. Am J Cardiol 39: 544
Smith HJ, Singh BN, Nisbet HD, Norris RM (1975) Effect of verapamil on infarct size following experimental coronary occlusion. Cardiovasc Res 9: 569
Nayler W, Grau A, Slade A (1976) A protective effect of verapamil on hypoxic heart muscle. Cardiovasc Res 10: 650
Dudel J, Peper K, Rudel R (1967) Effect of tetrodotoxin on the membrane current in cardiac muscle ( Purkinje fibers ). Pfluegers Arch 295: 213
Gettes LS, Reuter H (1974) Slow recovery from inactivation of inward currents in mammalian myocardial fibers. J Physiol 240: 703
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El-Sherif, N., Gomes, J.A.C., Kelen, G.J., Kahn, R.G., Kang, P.S., Zeiler, R.H. (1980). Electrophysiology of Reentrant Ventricular Arrhythmias in the Late Myocardial Infarction Period. In: Bircks, W., Loogen, F., Schulte, H.D., Seipel, L. (eds) Medical and Surgical Management of Tachyarrhythmias. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67597-3_2
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DOI: https://doi.org/10.1007/978-3-642-67597-3_2
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