Abstract
In paroxysmal reciprocating atrioventricular tachycardia (PRAVT), it is well established that anti-arrhythmic drugs may have an effect on one or more components of the re-entry circuit. These components depend for their depolarisation on fluxes of sodium or calcium ions [1], and agents that can specifically antagonise the transmembrane passage of these ions will have actions at specific sites. We have administered the sodium antagonist ajmaline and the calcium antagonist verapamil during intracardiac electrophysiological study. We have observed the ability of the drugs to terminate induced PRAVT, and then we examined the time-dependent changes in electrophysiological properties of the atrioventricular (AV) pathways, the accessory pathway (AP) on the one hand and the AV node on the other, in response to the drugs. As a result of these changes it is possible to comment on the effect on the mechanism of the tachycardia and more specifically on the ease of initiation.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Nayler WG (1975) The cellular basis for anti-arrhythmic therapy. In: Krikler DM, Goodwin JF (eds) Cardiac arrhythmias: The modern electrophysiological approach. Saunders, London, pp 208–222
Curry PVL (1975) Fundamentals of arrhythmias: modern methods of investigation. In: Krikler DM, Goodwin JF (eds) Cardiac arrhythmias: The modern electrophysiological approach. Saunders, London, pp 46–81
Coumel Ph, Attnel P, Slama R, Curry P, Krikler D (1976) Incessant tachycardias in Wolff-Parkinson-White syndrome. II. Role of atypical cycle length dependency and nodal-his escape beats in initiating reciprocating tachycardias. Br Heart J 38:897–905
Curry PVL, Rowland E, Fox KM, Krikler DM (1978) The relationship between posture, blood pressure and electrophysiological properties in patients with paroxysmal supraventricular tachycardia. Arch Mal Coeur 71:293–299
Coumel(1975) Supraventricular tachycardias. In: Krikler DM, Goodwin JF (eds) Cardiac arrhythmias: The modern electrophysiological approach. Saunders, London, pp 125–139
Krikler DM, Spurrell RAJ (1974) Verapamil in the treatment of paroxysmal supraventricular tachycardia. Postgrad Med J 50:447–453
Margiardi LM, Hariman RJ, McAllister RG, Bhargava V, Surawicz P, Shabetai R (1978) Electrophysiologic and hemodynamic effects of verapamil. Correlation with plasma drug concentrations. Circulation 57:366–372
Wellens HJ, Durrer D (1973) Effect of digitalis on atrioventricular conduction and circus-movement tachycardias in patients with the Wolff-Parkinson-White syndrome. Circulation 47:1229–1233
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Springer-Verlag Berlin-Heidelberg
About this paper
Cite this paper
Rowland, E., Krikler, F.M. (1980). Differential Responses to Sodium and Calcium Antagonists in Reciprocating Atrioventricular Tachycardia (WPW Syndrome). In: Fleckenstein, A., Roskamm, H. (eds) Calcium-Antagonismus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67595-9_6
Download citation
DOI: https://doi.org/10.1007/978-3-642-67595-9_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-67596-6
Online ISBN: 978-3-642-67595-9
eBook Packages: Springer Book Archive