Abstract
The antianginal effect of the so-called “calcium-antagonistic„ drugs has been demonstrated beyond doubt through numerous clinical studies [1]. However, their mode of action, both with regard to coronary and left ventricular as well as peripheral dynamics, still needs further analysis. Various “calcium-antagonists” are in clinical use today. The investigations reported here were performed exclusively with Nifedipine, the calcium antagonist with the strongest action on the coronary system and on left ventricular hemodynamics among those accepted for clinical use. Accordingly, mainly two problems are discussed: the effect of Nifedipine on the coronary system, and its action on left ventricular hemodynamics.
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Lichtlen, P.R., Engel, HJ., Wolf, R., Amende, I. (1980). The Effect of the Calcium-Antagonistic Drug Nifedipine on Coronary and Left Ventricular Dynamics in Patients with Coronary Heart Disease. In: Fleckenstein, A., Roskamm, H. (eds) Calcium-Antagonismus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67595-9_28
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DOI: https://doi.org/10.1007/978-3-642-67595-9_28
Publisher Name: Springer, Berlin, Heidelberg
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