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Detection of Coronary Artery Disease by First Pass Radionuclide Exercise Testing

  • J. A. Jengo
  • J. M. Uszler
  • R. Freeman
  • V. Oren
  • I. Mena
Conference paper

Abstract

Anatomic lesions of a coronary artery do not always equate with the presence of a functional abnormality in the area of myocardium formerly supplied by the stenosed vessel [1]. Even the muscle supplied by a totally occluded coronary artery may have adequate blood supply from collateral vessels. Although the myocardial blood supply in such cases may be adequate to meet the myocardial oxygen demand at rest, the blood supply may not be able to increase adequately to meet the increased myocardial oxygen demands during exercise stress. As a result, left ventricular dysfunction ensues [2,3].

Keywords

Ejection Fraction Left Ventricular Function Exercise Stress Regional Wall Motion Significant Coronary Artery Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Selzer A, Cohn K (1977) Asymptomatic coronary artery disease and coronary bypass surgery. Am J Cardiol 39: 614PubMedCrossRefGoogle Scholar
  2. 2.
    Tennant R, Wiggers CJ (1935) The effect of coronary occlusion on myocardial contractions. Am J Physiol 112: 351Google Scholar
  3. 3.
    Sharma B, Goodwin JF, Raphael MJ, Steiner RE, Rainbow RG, Taylor SH (1976) Left ventricular angiography on exercise: A new method of assessing left ventricular function in ischemic heart disease. Br Heart J 38: 59PubMedCrossRefGoogle Scholar
  4. 4.
    Redwood DR, Borer JS, Epstein SE (1976) Whither the ST segment during exercise? Circulation 54: 703PubMedGoogle Scholar
  5. 5.
    Borer JS, Brensike JF, Redwood ER, et al (1975) Limitations of the electrocardiographic response to exercise in predicting coronary-artery disease. N Engl J Med 293: 367PubMedCrossRefGoogle Scholar
  6. 6.
    Froelicher VF, Thompson AJ, Longo MR Jr, Triebwasser JH, Lancaster MC (1976) Value of exercise testing for screening asymptomatic men for latent coronary artery disease. Prog Cardiovasc Dis 18: 265PubMedCrossRefGoogle Scholar
  7. 7.
    Borer JS, Bacharach SL, Green MV, et al (1977) Real-time radionuclide cineangiography in the non-invasive evaluation of global and regional left ventricular function at rest and during exercise in patients with coronary-artery disease. N Engl J Med 296: 839PubMedCrossRefGoogle Scholar
  8. 8.
    Jengo JA, Mena I, Blaufuss A, Criley JM (to be published) Evaluation of left ventricular function (ejection fraction and segmental wall motion) by single pass radioisotope angiography. CirculationGoogle Scholar
  9. 9.
    Marshall RC, Berger HJ, Reduto LA, et al (1978) Variability in sequential measures of left ventricular performance assessed with radionuclide angiocardio graphy. Am J Cardiol 41: 531PubMedCrossRefGoogle Scholar
  10. 10.
    Pichard A (1976) Coronary arteriography for everyone? Am J Cardiol 38: 533PubMedCrossRefGoogle Scholar
  11. 11.
    Herman MD, Heinle RA, Klein MD, Gorlin R (1967) Localized disorders in myocardial contraction: Asynergy and its role in conjestive heart failture. N Engl J Med 277: 22PubMedCrossRefGoogle Scholar
  12. 12.
    Theroux P, Franklin D, Ross J, Kemper WS (1974) Regional myocardial function during acute coronary occlusion and its modification by pharmacologic agents in the dog. Circ Res 35: 896PubMedGoogle Scholar
  13. 13.
    Hamilton GW, Murray JA, Kennedy JW (1972) Quantitative angiography in ischemic heart disease: The spectrum of abnormal left ventricular function and the role of abnormally contracting segments. Circulation 45: 1065PubMedGoogle Scholar
  14. 14.
    Miller RR, Amsterdam EA, Bogren HG, et al (1974) Electrocardiographic and cineangiography correlations in assessment of the location, nature, and extent of abnormal left ventricular segmental contraction in coronary artery disease. Circulation 49: 447PubMedGoogle Scholar
  15. 15.
    Paternac A, Gorlin R, Sonnenblick EH, Haft JI, Kemp HG (1972) Abnormalities of ventricular motion induced by atrial pacing in coronary artery disease. Circulation 45: 1195Google Scholar
  16. 16.
    Forrester JS, Wyatt HL, Das Luz PL, et al (1976) Functional significance of regional ischemic contraction abnormalities. Circulation 54: 64PubMedGoogle Scholar
  17. 17.
    Bjork L, Cullhed I, Hallen A (1967) Cineangiocardiographic studies of the left ventricle in patients with angina pecotis. Circulation 36: 868PubMedGoogle Scholar
  18. 18.
    Bodenheimer MM, Banka VS, Fooshee CM, Hermann GA, Helfant RH (1978) Quantitative radionuclide angiography in the RAO view: Comparison with contrast ventriculography. Am J Cardiol 41: 718PubMedCrossRefGoogle Scholar
  19. 19.
    Pierson RN, Alam S, Kemp HG, et al (1977) Radiocardiography in clinical cardiology. Semin Nucl Med 7: 85PubMedCrossRefGoogle Scholar
  20. 20.
    Strauss HW, Pitt B (1978) Evaluation of cardiac function and structure with radioactive tracer techniques. Circulation 57: 645PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • J. A. Jengo
    • 1
    • 2
  • J. M. Uszler
    • 1
    • 2
  • R. Freeman
    • 1
    • 2
  • V. Oren
    • 1
    • 2
  • I. Mena
    • 1
    • 2
  1. 1.Nuclear Medicine DivisionHarbor General HospitalLos Angeles, TorranceUSA
  2. 2.University of CaliforniaLos Angeles, TorranceUSA

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