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Pharmacokinetic Imaging: A New Concept in Functional Imaging

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Frontiers in Nuclear Medicine
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Abstract

Pharmacokinetics is the study of the time course of drug distribution and metabolism in body fluids and tissues [1]. In nuclear medicine, the in vivo behavior of radiodiagnostic agents is often used to indicate an organ’s or organ system’s primary function, for instance, ventilation and perfusion of the lungs or cellular function by measurement of uptake and elimination of a tracer substance. The functional image was introduced as a kinetic parametric analysis method where regional rate constants were portrayed as images of regional function [2–4]. Recently the term functional image has been more widely used to describe other functions, including anatomic motion, perfusion, and ventilation [5–8].

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References

  1. Gibaldi M, Perrier D (1975) Pharmacokinetics, Marcel Dekker, New York, pp 45–95

    Google Scholar 

  2. Kaihara S, Natarajan T, Wagner Jr H, et al. (1969) Construction of a functional image from regional rate constants (abstr). J Nucl Med 10: 347

    Google Scholar 

  3. Pizer SM, Todd-Pokropek A (1974) Processing of noisy functional images. Presented at First World Congress of Nuclear Medicine, Tokyo, 1974

    Google Scholar 

  4. Raynaud C, Todd-Pokropek AE, Comar D (1974) A method for investigating regional variations of the cerebral uptake rate of c-labelled psychotropic drugs in man. In: Dynamic studies with radioisotopes in clinical medicine and research. IAEA, Symposium Oak Ridge

    Google Scholar 

  5. Alpert NM, Hoop Jr, B, Chesler DA (1974) Dynamic studies with a multiprogrammed computer system. In: Dynamic studies with radioisotopes in clinical medicine and research. IAEA, Symposium Oak Ridge

    Google Scholar 

  6. Toyama H, Iio M, Iisake J (1976) Color functional images of the cerebral blood flow. J Nucl Med 17: 953–958

    PubMed  CAS  Google Scholar 

  7. Sveinsdottir E, Larsen B, Rommer P (1977) A multidetector scintillation camera with 254 channels. J Nucl Med 18: 168–174

    PubMed  CAS  Google Scholar 

  8. Alpert NM, McKusick KA, Correia JA (1976) Initial assessment of a simple function al image of ventilation. J Nucl Med 17: 88–92

    PubMed  CAS  Google Scholar 

  9. Hayes RL (1977) The tissue distribution of gallium radionuclides. J Nucl Med 18: 740–742

    PubMed  CAS  Google Scholar 

  10. Gelrud LG, Arseneau JC, Milder MS (1974) The kinetics of 67Gallium incorporation into inflammatory lesions: Experimental and clinical studies. J Lab Clin Med 83: 489–495

    Google Scholar 

  11. Riggs DS (1963) The mathematical approach to physiological problems. M.I.T. Press Cambridge, pp 120–67

    Google Scholar 

  12. Sterling TD, Pollack SV (1968) Introduction to statistical data processing. Prentice-Hall, Englewood Cliffs, NJ pp 328–294

    Google Scholar 

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© 1980 Springer-Verlag Berlin Heidelberg

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Beihn, R., Vannier, M. (1980). Pharmacokinetic Imaging: A New Concept in Functional Imaging. In: Horst, W., Wagner, H.N., Buchanan, J.W. (eds) Frontiers in Nuclear Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67575-1_10

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  • DOI: https://doi.org/10.1007/978-3-642-67575-1_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-09895-9

  • Online ISBN: 978-3-642-67575-1

  • eBook Packages: Springer Book Archive

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