Skip to main content
  • 118 Accesses

Abstract

We have observed over the past few years a sharp increase in the number of spontaneous abortions in which the embryo was abnormally developed, and we began searching our patients’ medical histories for possible causes. Realizing that either primary damage to the germ cell or the inability of the endometrium to act as a nidation bed can lead to these symptoms, we focused our attention on the various drugs that have a noxious effect on ovary and endometrium. The logical step, of course, was to look at oral contraceptives, the consumption of which has risen very rapidly over the past 10 years.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • BouĂ© J, BouĂ© A, Zazar P (1975) The epidemiology of human spontaneous abortions with chromosomal anomalies, aging gametes. Blandau RJ (ed) Karger, Basel

    Google Scholar 

  • Carr DH (1969) Genetic factors in pregnancy wastage. Med Clin North Am 53: 5

    Google Scholar 

  • Carr DH (1970) Chromosome studies in selected spontaneous abortions 1. Conception after oral contraceptives. Can Med Assoc J 103: 343

    PubMed  CAS  Google Scholar 

  • Dallenbach-Hellweg G (1972) Therapieschäden in der Gynäkologie (Morphologische Beobachtungen ĂĽber die Auswirkungen weiblicher Sexualhormone und von Stoffen mit ahnlicher Wirkung). Verh Dtsch Ges Pathol 56: 252

    PubMed  CAS  Google Scholar 

  • Dhadial RK, Machin AM, Tait SM (1970) Chromosomal anomalies in spontaneously aborted human fetuses. Lancet 11: 20

    Article  Google Scholar 

  • Diddle AW, Watts GF, Gardner WH, Williamson PJ (1966) Oral contraceptive medication: a prolonged experience. Am J Obstet Gynecol 95: 489

    PubMed  CAS  Google Scholar 

  • Ferin J (1964) Hypoestrogenic amenorrhoea and/or sterility induced by lynestrenol. Int J Fertil 9: 29

    PubMed  CAS  Google Scholar 

  • Klinger HP, Glasser M, Kava HW (1976) Contraceptives and the conceptus. I. Chromosome abnormalities of the fetus and neonate related to maternal contraceptive history. Obstet Gynecol 48: 40

    PubMed  CAS  Google Scholar 

  • Knörr K, Haas B (1971) Cytogenetische Untersuchungen bei Einnahme von Ovulationshemmern. In: Kewitz H (Hrsg) Nebenwirkungen contraceptiver Steroide. Westkreuz, Berlin, p 116

    Google Scholar 

  • KĂĽhne D, Seidl S, Göretzlehner G (1972) Contraceptive treatment with chlormadinone and its effect on the endometrium. A histological investigation. Endokrinologie 59: 295

    PubMed  Google Scholar 

  • Lauritzen JG (1975) The significance of oral contraceptives in causing chromosome anomalies in spontaneous abortions. Acta Obstet Gynecol Scand 54: 261

    Article  Google Scholar 

  • Del Mazo J, Abrisqueta JA (1979) Maternal origin of a trisomy 7 in a spontaneous abortion. Obstet Gynecol 53: 185

    Google Scholar 

  • McQuarrie HG, Scott CD, Ellsworth HS, Harris JW, Stone RA (1970) Cytogenetic studies on women using oral contraceptives and their progeny. J Obstet Gynecol 108: 659

    CAS  Google Scholar 

  • Plate WP (1967) Ovarian changes after long-term oral contraception. Acta Endocrinol (Kbh) 55: 71

    CAS  Google Scholar 

  • Poland BJ (1970) Conception control and embryonic development. Am J Obstet Gynecol 106: 365

    PubMed  CAS  Google Scholar 

  • Pujol-Amat P, Urgell-Roca JM, Esterben-Altirriba J, Marquez-Ramirez M (1969) Studies of ovarian biopsies from women cyclically treated with the combination ethynodiol-diacetate and mestranol alone and together with human menopausal gonadotropin ( Pergonal) + HCG. Gynaecologica 167: 237

    CAS  Google Scholar 

  • Ryan GM, Craig J, Reid DE (1964) Histology of the uterus and ovaries after long-term cyclic norethynodrel therapy. Am J Obstet Gynecol 90: 715

    PubMed  Google Scholar 

  • Starup J (1967) The effect of gestagen and oestrogen treatment on the development of ovarian follicles: laboratory observations. Acta Obstet Gynecol Scand [Suppl9] 46: 1

    Google Scholar 

  • Zussman WK, Forbes DA, Carpenter RJ Jr (1967) Ovarian morphology following cyclic norethindrone-mestranol therapy. Am J Obstet Gynecol 99: 99

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Dallenbach-Hellweg, G. (1980). The Frequency of Spontaneous Abortion After Discontinuance of Oral Contraceptives. In: Dallenbach-Hellweg, G. (eds) Functional Morphologic Changes in Female Sex Organs Induced by Exogenous Hormones. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67568-3_22

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-67568-3_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-67570-6

  • Online ISBN: 978-3-642-67568-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics