The Frequency of Spontaneous Abortion After Discontinuance of Oral Contraceptives

  • Gisela Dallenbach-Hellweg

Abstract

We have observed over the past few years a sharp increase in the number of spontaneous abortions in which the embryo was abnormally developed, and we began searching our patients’ medical histories for possible causes. Realizing that either primary damage to the germ cell or the inability of the endometrium to act as a nidation bed can lead to these symptoms, we focused our attention on the various drugs that have a noxious effect on ovary and endometrium. The logical step, of course, was to look at oral contraceptives, the consumption of which has risen very rapidly over the past 10 years.

Keywords

Estrogen Progesterone Dial Haas Norgestrel 

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References

  1. Boué J, Boué A, Zazar P (1975) The epidemiology of human spontaneous abortions with chromosomal anomalies, aging gametes. Blandau RJ (ed) Karger, BaselGoogle Scholar
  2. Carr DH (1969) Genetic factors in pregnancy wastage. Med Clin North Am 53: 5Google Scholar
  3. Carr DH (1970) Chromosome studies in selected spontaneous abortions 1. Conception after oral contraceptives. Can Med Assoc J 103: 343PubMedGoogle Scholar
  4. Dallenbach-Hellweg G (1972) Therapieschäden in der Gynäkologie (Morphologische Beobachtungen über die Auswirkungen weiblicher Sexualhormone und von Stoffen mit ahnlicher Wirkung). Verh Dtsch Ges Pathol 56: 252PubMedGoogle Scholar
  5. Dhadial RK, Machin AM, Tait SM (1970) Chromosomal anomalies in spontaneously aborted human fetuses. Lancet 11: 20CrossRefGoogle Scholar
  6. Diddle AW, Watts GF, Gardner WH, Williamson PJ (1966) Oral contraceptive medication: a prolonged experience. Am J Obstet Gynecol 95: 489PubMedGoogle Scholar
  7. Ferin J (1964) Hypoestrogenic amenorrhoea and/or sterility induced by lynestrenol. Int J Fertil 9: 29PubMedGoogle Scholar
  8. Klinger HP, Glasser M, Kava HW (1976) Contraceptives and the conceptus. I. Chromosome abnormalities of the fetus and neonate related to maternal contraceptive history. Obstet Gynecol 48: 40PubMedGoogle Scholar
  9. Knörr K, Haas B (1971) Cytogenetische Untersuchungen bei Einnahme von Ovulationshemmern. In: Kewitz H (Hrsg) Nebenwirkungen contraceptiver Steroide. Westkreuz, Berlin, p 116Google Scholar
  10. Kühne D, Seidl S, Göretzlehner G (1972) Contraceptive treatment with chlormadinone and its effect on the endometrium. A histological investigation. Endokrinologie 59: 295PubMedGoogle Scholar
  11. Lauritzen JG (1975) The significance of oral contraceptives in causing chromosome anomalies in spontaneous abortions. Acta Obstet Gynecol Scand 54: 261CrossRefGoogle Scholar
  12. Del Mazo J, Abrisqueta JA (1979) Maternal origin of a trisomy 7 in a spontaneous abortion. Obstet Gynecol 53: 185Google Scholar
  13. McQuarrie HG, Scott CD, Ellsworth HS, Harris JW, Stone RA (1970) Cytogenetic studies on women using oral contraceptives and their progeny. J Obstet Gynecol 108: 659Google Scholar
  14. Plate WP (1967) Ovarian changes after long-term oral contraception. Acta Endocrinol (Kbh) 55: 71Google Scholar
  15. Poland BJ (1970) Conception control and embryonic development. Am J Obstet Gynecol 106: 365PubMedGoogle Scholar
  16. Pujol-Amat P, Urgell-Roca JM, Esterben-Altirriba J, Marquez-Ramirez M (1969) Studies of ovarian biopsies from women cyclically treated with the combination ethynodiol-diacetate and mestranol alone and together with human menopausal gonadotropin ( Pergonal) + HCG. Gynaecologica 167: 237Google Scholar
  17. Ryan GM, Craig J, Reid DE (1964) Histology of the uterus and ovaries after long-term cyclic norethynodrel therapy. Am J Obstet Gynecol 90: 715PubMedGoogle Scholar
  18. Starup J (1967) The effect of gestagen and oestrogen treatment on the development of ovarian follicles: laboratory observations. Acta Obstet Gynecol Scand [Suppl9] 46: 1Google Scholar
  19. Zussman WK, Forbes DA, Carpenter RJ Jr (1967) Ovarian morphology following cyclic norethindrone-mestranol therapy. Am J Obstet Gynecol 99: 99PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • Gisela Dallenbach-Hellweg

There are no affiliations available

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