The Mechanism of Effect of Estrogens

Abstract

In 1960 Jensen and Jacobson provided evidence for a specific binding of estrogens in target organs. This specific binding is the basic requirement for the biological action of estrogens. These actions include stimulation of the synthesis of proteins, for instance enzymes and other steroid hormone receptors.

In addition the data of the present paper indicate that the biological action of estrogens is also involved in the synthesis of prostaglandins being essential for the contractility of the myometrium. The intrauterine application of estradiol valerianate in low doses results in rapid increase of the PGE₂-synthesis. High doses of estrogens, however, are followed by a decreased synthesis of PGE₂.

The biological significance of these results will be discussed in detail.