Cerebrospinal Fluid Findings in Japanese Patients with Multiple Sclerosis

  • H. Iwashita
  • Y. Kuroiwa
Conference paper


Recent reports [7, 8, 9, 16] have shown that multiple sclerosis (MS) in Japan, except for its low prevalence rate (estimated to be 1–4 per 100,000 population), is essentially the same as MS in Western countries. However, some [7, 8, 9] of these reports have also pointed out that a racial factor might well be involved in epidemiological and clinical statistics (symptoms and signs) in MS in Japan. Therefore, it is of interest to study the fundamental cerebrospinal fluid (CSF) findings in Japanese patients with MS. It is the purpose of this paper to report the CSF findings in Japanese MS patients.


Multiple Sclerosis Measle Virus Hemagglutination Inhibition Agarose Electrophoresis Multiple Sclerosis Case 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bader R, Rieder HP, Kaeser HE (1973) Die Bedeutung der diskontinuierlichen Zonierung des Immunoglobulinbereiches für die Diagnose neurologischer Erkrankungen. Z Neurol 206:25–38PubMedCrossRefGoogle Scholar
  2. 2.
    Delmotte P, Gonsette R (1977) Biochemical findings in multiple sclerosis. IV. Isoelectric focusing of the CSF gamma globulins in multiple sclerosis (262 cases) and other. J Neurol 215:27–37PubMedCrossRefGoogle Scholar
  3. 3.
    Iwashita H, Bauer H, Kuroiwa Y (1976) Comparative studies of cerebrospinal fluid proteins of multiple sclerosis patients in Japan and Germany. Neurology (Minneap) 26(6, part 2):37–38Google Scholar
  4. 4.
    Iwashita H, Araki H, Kuroiwa Y, Matsumoto T (1978) Candida specific oligoclonal CSF IgG in Candida meningoencephalitis. Ann Neurol 4:579–581PubMedCrossRefGoogle Scholar
  5. 5.
    Johnson KP, Arrigo SC, Nelson BG, Ginsberg A (1977) Agarose electrophoresis of cerebrospinal fluid in multiple sclerosis. A simplified method for demonstrating cerebrospinal fluid oligoclonal immunoglobulin bands. Neurology (Minneap) 27:273–277Google Scholar
  6. 6.
    Kolar OG, Ross AT, Herman JT (1970) Serum and cerebrospinal fluid immunoglobulins in multiple sclerosis. Neurology (Minneap) 20:1052–1061Google Scholar
  7. 7.
    Kuroiwa Y, Shibasaki H (1973) Clinical studies of multiple sclerosis in Japan. Neurology (Minneap) 23:609–617Google Scholar
  8. 8.
    Kuroiwa Y, Shibasaki H (1976) Epidemiologic and clinical studies of multiple sclerosis in Japan. Neurology (Minneap), 26:8–10Google Scholar
  9. 9.
    Kuroiwa Y, Igata A, Itahara K, Koshijima S, Tsubaki T, Toyokura Y, Shibasaki H (1975) Nationwide survey of multiple sclerosis in Japan: Clinical analysis of 1,084 cases. Neurology (Minneap) 25:845–851Google Scholar
  10. 10.
    Lamoureux T, Golicoeur R, Giard N, St-Hilaire M (1975) Cerebrospinal fluid proteins in multiple sclerosis. Neurology (Minneap) 25:537–546Google Scholar
  11. 11.
    Laterre EC, Callewaert A, Heremans JH, Sfaello Z (1970) Electrophoretic morphology of gamma globulins in cerebrospinal fluid of multiple sclerosis and other diseases of the nervous system. Neurology (Minneap) 20:982–990Google Scholar
  12. 12.
    Link H, Müller R (1971) Immunoglobulins in multiple sclerosis and infections of the nervous system. Arch Neurol 25:326–344PubMedGoogle Scholar
  13. 13.
    McAlpine D, Compston ND, Lumsden CE (1972) CSF cell counts in multiple sclerosis. In: McAlpine D, Lumsden CE, Acheson ED (eds) Multiple sclerosis. A reappraisal, 2nd edn. Livingston, Edinburg London, p 326Google Scholar
  14. 14.
    Nordal HG, Vandvik B, Norrby E (1978) Multiple sclerosis: Local synthesis of electropho-retically restricted measles, rubella, mumps and herpes simplex virus antibodies in the central nervous system. Scand J Immunol 7:473–479PubMedCrossRefGoogle Scholar
  15. 15.
    Sakata H, Yamanouchi K, Machida K, Matsuzaki S (1977) Quantitations of measles antibodies by radioimmunoassay (RIA). Clin Virus 5:364–366Google Scholar
  16. 16.
    Satoyoshi E, Saku A, Sunohara H, Kinoshita M (1976) Clinical manifestations and the diagnostic problems of multiple sclerosis in Japan. Neurology (Minneap), 26:23–25Google Scholar
  17. 17.
    Tourtellotte WW (1970) Cerebrospinal fluid in multiple sclerosis. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, vol 9. North Holland, Amsterdam, p 324Google Scholar
  18. 18.
    Vandvik B, Degré M (1975) Measles virus antibodies in serum and cerebrospinal fluid in patients with multiple sclerosis and other neurological disorders, with special reference to measles antibody synthesis within the central nervous system. J Neurol Sci 24:201–219PubMedCrossRefGoogle Scholar
  19. 19.
    Vandvik B, Norrby E (1973) Oligoclonal IgG antibody response in the central nervous system to different measles virus antigens in subacute sclerosing panencephalitis. Proc Natl Acad Sci USA 70:1060–1063PubMedCrossRefGoogle Scholar
  20. 20.
    Vandvik B, Weil ML, Grandien M, Norrby E (1978) Progressive rubella virus panencephalitis: Synthesis of oligoclonal virus-specific IgG antibodies and homogenous free light chains in the central nervous system. Acta Neurol Scand 57:53–64PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • H. Iwashita
  • Y. Kuroiwa
    • 1
  1. 1.Department of Neurology, Neurological Institute, Faculty of MedicineKyushu University60, Fukuoka City 812Japan

Personalised recommendations