Cerebrospinal Fluid Findings in Japanese Patients with Multiple Sclerosis
Recent reports [7, 8, 9, 16] have shown that multiple sclerosis (MS) in Japan, except for its low prevalence rate (estimated to be 1–4 per 100,000 population), is essentially the same as MS in Western countries. However, some [7, 8, 9] of these reports have also pointed out that a racial factor might well be involved in epidemiological and clinical statistics (symptoms and signs) in MS in Japan. Therefore, it is of interest to study the fundamental cerebrospinal fluid (CSF) findings in Japanese patients with MS. It is the purpose of this paper to report the CSF findings in Japanese MS patients.
KeywordsMultiple Sclerosis Measle Virus Hemagglutination Inhibition Agarose Electrophoresis Multiple Sclerosis Case
Unable to display preview. Download preview PDF.
- 3.Iwashita H, Bauer H, Kuroiwa Y (1976) Comparative studies of cerebrospinal fluid proteins of multiple sclerosis patients in Japan and Germany. Neurology (Minneap) 26(6, part 2):37–38Google Scholar
- 5.Johnson KP, Arrigo SC, Nelson BG, Ginsberg A (1977) Agarose electrophoresis of cerebrospinal fluid in multiple sclerosis. A simplified method for demonstrating cerebrospinal fluid oligoclonal immunoglobulin bands. Neurology (Minneap) 27:273–277Google Scholar
- 6.Kolar OG, Ross AT, Herman JT (1970) Serum and cerebrospinal fluid immunoglobulins in multiple sclerosis. Neurology (Minneap) 20:1052–1061Google Scholar
- 7.Kuroiwa Y, Shibasaki H (1973) Clinical studies of multiple sclerosis in Japan. Neurology (Minneap) 23:609–617Google Scholar
- 8.Kuroiwa Y, Shibasaki H (1976) Epidemiologic and clinical studies of multiple sclerosis in Japan. Neurology (Minneap), 26:8–10Google Scholar
- 9.Kuroiwa Y, Igata A, Itahara K, Koshijima S, Tsubaki T, Toyokura Y, Shibasaki H (1975) Nationwide survey of multiple sclerosis in Japan: Clinical analysis of 1,084 cases. Neurology (Minneap) 25:845–851Google Scholar
- 10.Lamoureux T, Golicoeur R, Giard N, St-Hilaire M (1975) Cerebrospinal fluid proteins in multiple sclerosis. Neurology (Minneap) 25:537–546Google Scholar
- 11.Laterre EC, Callewaert A, Heremans JH, Sfaello Z (1970) Electrophoretic morphology of gamma globulins in cerebrospinal fluid of multiple sclerosis and other diseases of the nervous system. Neurology (Minneap) 20:982–990Google Scholar
- 13.McAlpine D, Compston ND, Lumsden CE (1972) CSF cell counts in multiple sclerosis. In: McAlpine D, Lumsden CE, Acheson ED (eds) Multiple sclerosis. A reappraisal, 2nd edn. Livingston, Edinburg London, p 326Google Scholar
- 15.Sakata H, Yamanouchi K, Machida K, Matsuzaki S (1977) Quantitations of measles antibodies by radioimmunoassay (RIA). Clin Virus 5:364–366Google Scholar
- 16.Satoyoshi E, Saku A, Sunohara H, Kinoshita M (1976) Clinical manifestations and the diagnostic problems of multiple sclerosis in Japan. Neurology (Minneap), 26:23–25Google Scholar
- 17.Tourtellotte WW (1970) Cerebrospinal fluid in multiple sclerosis. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, vol 9. North Holland, Amsterdam, p 324Google Scholar