Skip to main content
SpringerLink
Log in

Cerebrospinal Fluid Findings in Japanese Patients with Multiple Sclerosis

  • Conference paper
Progress in Multiple Sclerosis Research

  • 65 Accesses

Abstract

Recent reports [7, 8, 9, 16] have shown that multiple sclerosis (MS) in Japan, except for its low prevalence rate (estimated to be 1–4 per 100,000 population), is essentially the same as MS in Western countries. However, some [7, 8, 9] of these reports have also pointed out that a racial factor might well be involved in epidemiological and clinical statistics (symptoms and signs) in MS in Japan. Therefore, it is of interest to study the fundamental cerebrospinal fluid (CSF) findings in Japanese patients with MS. It is the purpose of this paper to report the CSF findings in Japanese MS patients.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bader R, Rieder HP, Kaeser HE (1973) Die Bedeutung der diskontinuierlichen Zonierung des Immunoglobulinbereiches für die Diagnose neurologischer Erkrankungen. Z Neurol 206:25–38

    Article  PubMed  CAS  Google Scholar 

  2. Delmotte P, Gonsette R (1977) Biochemical findings in multiple sclerosis. IV. Isoelectric focusing of the CSF gamma globulins in multiple sclerosis (262 cases) and other. J Neurol 215:27–37

    Article  PubMed  CAS  Google Scholar 

  3. Iwashita H, Bauer H, Kuroiwa Y (1976) Comparative studies of cerebrospinal fluid proteins of multiple sclerosis patients in Japan and Germany. Neurology (Minneap) 26(6, part 2):37–38

    CAS  Google Scholar 

  4. Iwashita H, Araki H, Kuroiwa Y, Matsumoto T (1978) Candida specific oligoclonal CSF IgG in Candida meningoencephalitis. Ann Neurol 4:579–581

    Article  PubMed  CAS  Google Scholar 

  5. Johnson KP, Arrigo SC, Nelson BG, Ginsberg A (1977) Agarose electrophoresis of cerebrospinal fluid in multiple sclerosis. A simplified method for demonstrating cerebrospinal fluid oligoclonal immunoglobulin bands. Neurology (Minneap) 27:273–277

    CAS  Google Scholar 

  6. Kolar OG, Ross AT, Herman JT (1970) Serum and cerebrospinal fluid immunoglobulins in multiple sclerosis. Neurology (Minneap) 20:1052–1061

    Google Scholar 

  7. Kuroiwa Y, Shibasaki H (1973) Clinical studies of multiple sclerosis in Japan. Neurology (Minneap) 23:609–617

    CAS  Google Scholar 

  8. Kuroiwa Y, Shibasaki H (1976) Epidemiologic and clinical studies of multiple sclerosis in Japan. Neurology (Minneap), 26:8–10

    CAS  Google Scholar 

  9. Kuroiwa Y, Igata A, Itahara K, Koshijima S, Tsubaki T, Toyokura Y, Shibasaki H (1975) Nationwide survey of multiple sclerosis in Japan: Clinical analysis of 1,084 cases. Neurology (Minneap) 25:845–851

    CAS  Google Scholar 

  10. Lamoureux T, Golicoeur R, Giard N, St-Hilaire M (1975) Cerebrospinal fluid proteins in multiple sclerosis. Neurology (Minneap) 25:537–546

    CAS  Google Scholar 

  11. Laterre EC, Callewaert A, Heremans JH, Sfaello Z (1970) Electrophoretic morphology of gamma globulins in cerebrospinal fluid of multiple sclerosis and other diseases of the nervous system. Neurology (Minneap) 20:982–990

    CAS  Google Scholar 

  12. Link H, Müller R (1971) Immunoglobulins in multiple sclerosis and infections of the nervous system. Arch Neurol 25:326–344

    PubMed  CAS  Google Scholar 

  13. McAlpine D, Compston ND, Lumsden CE (1972) CSF cell counts in multiple sclerosis. In: McAlpine D, Lumsden CE, Acheson ED (eds) Multiple sclerosis. A reappraisal, 2nd edn. Livingston, Edinburg London, p 326

    Google Scholar 

  14. Nordal HG, Vandvik B, Norrby E (1978) Multiple sclerosis: Local synthesis of electropho-retically restricted measles, rubella, mumps and herpes simplex virus antibodies in the central nervous system. Scand J Immunol 7:473–479

    Article  PubMed  CAS  Google Scholar 

  15. Sakata H, Yamanouchi K, Machida K, Matsuzaki S (1977) Quantitations of measles antibodies by radioimmunoassay (RIA). Clin Virus 5:364–366

    Google Scholar 

  16. Satoyoshi E, Saku A, Sunohara H, Kinoshita M (1976) Clinical manifestations and the diagnostic problems of multiple sclerosis in Japan. Neurology (Minneap), 26:23–25

    CAS  Google Scholar 

  17. Tourtellotte WW (1970) Cerebrospinal fluid in multiple sclerosis. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, vol 9. North Holland, Amsterdam, p 324

    Google Scholar 

  18. Vandvik B, Degré M (1975) Measles virus antibodies in serum and cerebrospinal fluid in patients with multiple sclerosis and other neurological disorders, with special reference to measles antibody synthesis within the central nervous system. J Neurol Sci 24:201–219

    Article  PubMed  CAS  Google Scholar 

  19. Vandvik B, Norrby E (1973) Oligoclonal IgG antibody response in the central nervous system to different measles virus antigens in subacute sclerosing panencephalitis. Proc Natl Acad Sci USA 70:1060–1063

    Article  PubMed  CAS  Google Scholar 

  20. Vandvik B, Weil ML, Grandien M, Norrby E (1978) Progressive rubella virus panencephalitis: Synthesis of oligoclonal virus-specific IgG antibodies and homogenous free light chains in the central nervous system. Acta Neurol Scand 57:53–64

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology, Neurological Institute, Faculty of Medicine, Kyushu University, 60, Fukuoka City 812, Japan

    Y. Kuroiwa

Authors
  1. H. Iwashita
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Y. Kuroiwa
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Neurologische Klinik und Poliklinik, Neues Klinikum, Universität Göttingen, Robert-Koch-Straße 40, 3400, Göttingen, Germany

    H. J. Bauer , S. Poser  & G. Ritter ,  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Iwashita, H., Kuroiwa, Y. (1980). Cerebrospinal Fluid Findings in Japanese Patients with Multiple Sclerosis. In: Bauer, H.J., Poser, S., Ritter, G. (eds) Progress in Multiple Sclerosis Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67554-6_96

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-67554-6_96

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-67556-0

  • Online ISBN: 978-3-642-67554-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation