Search for Viral Nucleic Acids in Multiple Sclerosis Brain
A viral etiology for multiple sclerosis has been suggested for many years, since epidemiological observations tend to call for an agent which is acquired early in life and which after a long period of latency initiates a disease process. Various virological studies have compared the frequency of antibodies against common viruses in the serum and cerebral spinal fluid of MS patients to matched controls and patients without neurological diseases. Although measles virus seemed to be the prime candidate for a causative agent in MS, increased antibody titers against other common viruses such as herpes simplex virus, cytomegalovirus, varicella, and adenovirus, as well as influenza C, parainfluenza 3, mumps, and rubella viruses have also been reported in MS cases. In addition, oligoclonal IgG bands in CSF material are present in approximately 90% of MS patients, suggesting a local antibody production directed against viral and other unknown antigens . These observations have prompted many attempts to isolate infectious virus from MS brain, but the different agents recovered could not be linked etiologically or pathogenetically to this chronic CNS disorder.
KeywordsSucrose Phenol Lymphoma Adenoma Influenza
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