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Discussion

  • H. J. Bauer
  • S. Poser
  • G. Ritter
Conference paper

Abstract

I would like to comment on the radioimmunoassay technique: you know that labeling of the protein with iodine sometimes produces loss of EAE-inducing activity. The molecular conformation is important, and in some cases this may be changed by iodination. Secondly, if you use rabbits for immunization, they sometimes produce a very different kind of antibody. With some antibodies, there is a variety in recognizing the basic protein. Thirdly, you know that some fragments in MS and EAE basic protein may be degraded in various ways. Maybe a different kind of fragment of MBP will be produced and some antibody can actually recognize such a fragment but another serum cannot recognize it. So it depends on the MBP fragments produced.

Keywords

Multiple Sclerosis Head Injury Posterior Fossa Basic Protein Rabbit Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • H. J. Bauer
    • 1
  • S. Poser
    • 1
  • G. Ritter
    • 1
  1. 1.Neurologische Klinik und Poliklinik, Neues KlinikumUniversität GöttingenGöttingenGermany

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