In Vitro Demyelination by Lymphocytes and Lymphokines from Patients and Experimental Animals
Demyelinating change is a characteristic feature of demyelinating diseases. The mechanism involved has been thought to be cell-mediated immune processes characterized by activation of macrophages, which invade and phagocytize the myelin sheaths and the autophage of myelin debris in the myelin supporting cells. In addition, degenerative changes in sheaths, such as vesicular dissolution, are often observed.
KeywordsMyelin Basic Protein Myelin Sheath Node Cell Demyelinating Disease Experimental Allergic Encephalomyelitis
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