In Vitro Demyelination by Lymphocytes and Lymphokines from Patients and Experimental Animals

  • T. Yonezawa
  • N. Arizono
  • M. Hasegawa
  • Y. Yamamura
  • H. Miyaji
Conference paper


Demyelinating change is a characteristic feature of demyelinating diseases. The mechanism involved has been thought to be cell-mediated immune processes characterized by activation of macrophages, which invade and phagocytize the myelin sheaths and the autophage of myelin debris in the myelin supporting cells. In addition, degenerative changes in sheaths, such as vesicular dissolution, are often observed.


Myelin Basic Protein Myelin Sheath Node Cell Demyelinating Disease Experimental Allergic Encephalomyelitis 
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  1. 1.
    Arnason BGW, Winkler GF, Hadler NM (1969) Cell-mediated demyelination of peripheral nerve in tissue culture. Lab Invest 21:1PubMedGoogle Scholar
  2. 2.
    Aström KE, Waksman BH (1962) The passive transfer of experimental allergic encephalomyelitis and neuritis with living lymphoid cells. J Pathol Bacteriol 83:89PubMedCrossRefGoogle Scholar
  3. 3.
    Bornstein MB, Appel SH (1961) The application of tissue culture to the study of experimental allergic encephalomyelitis. I. Patterns of demyelination. J Neuropathol Exp Neurol 20:141CrossRefGoogle Scholar
  4. 4.
    Bornstein MB, Iwanami H (1971) Experimental allergic encephalomyelitis. Demyelinating activity of serum and sensitized lymph node cells on cultured nerve tissue. J Neuropathol Exp Neurol 30:240PubMedCrossRefGoogle Scholar
  5. 5.
    Ellison GW, Waksman BH, Ruddle NH (1971) Experimental autoallergic encephalomyelitis and cellular hypersensitivity in vitro. Neurology (Minneap) 21:778Google Scholar
  6. 6.
    Fry JM, Weissbarth S, Lehrer GM, Bornstein MB (1974) Cerebroside antibody inhibits sulfatide synthesis and myelination and demyelinates in cord tissue cultures. Science 183:540PubMedCrossRefGoogle Scholar
  7. 7.
    Paterson PY (1968) Transfer of allergic encephalomyelitis in rats by means of lymph node cells. J Exp Med 111:119CrossRefGoogle Scholar
  8. 8.
    Russell SW, Rosenau W, Goldberg ML, Kunitomi G (1972) Purification of human lym-photoxin. J Immunol 109:784PubMedGoogle Scholar
  9. 9.
    Steinmetz PR (1973) Lymphocyte mediators and cellular hypersensitivity. N Engl J Med 288:143CrossRefGoogle Scholar
  10. 10.
    Yonezawa T, Ishihara Y (1969) Demyelinating pattern of experimental allergic peripheral neuritis studied in vitro. In: Pathogenesis and Etiology of Demyelinating Diseases, S. Karger, 36:629Google Scholar
  11. 11.
    Yonezawa T, Ishihara Y, Matsuyama H (1968) Studies of experimental allergic peripheral neuritis. I. Demyelinating patterns in vitro. J Neuropathol Exp Neurol 27:453CrossRefGoogle Scholar
  12. 12.
    Yonezawa T, Saida T, Hasegawa M (1976) Demyelinating pattern with EAE and EAN an-tisera studied in vitro: Time lapse cinematographic analysis. Neurology (Minneap) 26:42PubMedGoogle Scholar
  13. 13.
    Yonezawa T, Saida T, Hasegawa M (1976) Myelination inhibiting factor in experimental allergic encephalomyelitis and demyelinating diseases. In: Shiraki H, Yonezawa T, Kuroiwa Y (eds) The aetiology and pathogenesis of the demyelinating diseases. Japanese Society of Neuropathology, Kyoto, p 255Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • T. Yonezawa
  • N. Arizono
  • M. Hasegawa
  • Y. Yamamura
  • H. Miyaji
    • 1
  1. 1.Department of PathologyKyoto Prefectural University of MedicineKyotoJapan

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