Brain Free Fatty Acids after Transient Global Brain Ischemia with Postinsult Thiopental Therapy

  • E. M. Nemoto
  • G. K. Shiu
  • J. R. Gilbertson
  • H. Alexander
Conference paper


A metabolic basis for barbiturate amelioration of ischemic brain damage is not demonstrable in terms of the rate and magnitude of changes in brain high energy phosphates, glycolytic metabolites and Krebs cycle intermediates during (7,8) or after (9) complete global brain ischemia. Yet, the efficacy of barbiturate therapy in improving neurologic recovery when administered before (4) or after (2) complete global ischemia has been clearly demonstrated.


Ischemic Brain Damage Global Brain Ischemia Krebs Cycle Intermediate Complete Ischemia Citric Acid Cycle Intermediate 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • E. M. Nemoto
  • G. K. Shiu
  • J. R. Gilbertson
  • H. Alexander

There are no affiliations available

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