Brain Free Fatty Acids after Transient Global Brain Ischemia with Postinsult Thiopental Therapy
A metabolic basis for barbiturate amelioration of ischemic brain damage is not demonstrable in terms of the rate and magnitude of changes in brain high energy phosphates, glycolytic metabolites and Krebs cycle intermediates during (7,8) or after (9) complete global brain ischemia. Yet, the efficacy of barbiturate therapy in improving neurologic recovery when administered before (4) or after (2) complete global ischemia has been clearly demonstrated.
KeywordsIschemia Lactate Norepinephrine Catecholamine Oleate
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- 6.Kessler P, Nemoto EM (1977) Pathogenesis of postischemic (PI) encephalopathy. Fed Proc 36:588 Abstract #1667Google Scholar
- 8.Nordstrom C-H, Rehncrona S, Siesjo BK (1978) Restitution of cerebral energy state as well as of glycolytic metabolites, citric acid cycle intermediates and associated amino acids after 30 minutes of complete ischemia in rats anesthetized with nitrous oxide or pentobarbital. J Neurochem 30:479–486PubMedCrossRefGoogle Scholar