The Role of Brain Tissue Pressure in Autoregulation of CBF in Areas of Brain Edema
The laboratory model of brain edema produced by cryogenic injury produces a rise in the intracranial pressure and a uniform reduction of cerebral blood flow in the area of the lesion (3). Both these events have been attributed to the compressive effects of the increased tissue volume. The objective of this study was to isolate pressure and volume effects and test the autoregulatory dynamics in the edematous area to help clarify the interaction between local pressures and mechanisms of CBF control.
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