Effects of Hypercapnia and Systemic Arterial Hypo- and Hypertension on the Interrelation between CSF Pulse Pressure and Volume-Pressure Response
The interrelation between CSF pulse pressure (CSFPP) and volume-pressure response (VPR) has been previously described (1,2). These studies had been oriented toward clinical applicability: continuous monitoring of intracranial volume-pressure (V/P) relationships by means of CSFPP. A disturbing factor, however, is the variable volume change underlying CSFPP: the transient increase in cerebral blood volume per cardiac cycle (ΔV). The origin of AV was attributed to the difference between the pulsatile patterns of the cerebral arterial inflow and venous outflow of blood (1). Hemodynamic factors may thus be expected to affect AV and consequently CSFPP. An experimental study was therefore designed to investigate the effects of some major clinical variables, hypercapnia and arterial hypo- and hypertension, on the interrelation between CSFPP and VPR.
KeywordsPulse Pressure Cerebral Blood Volume Intracranial Volume Arterial Hypotension Inical Variable
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- 1.Avezaat CJJ, Van Eijndhoven JHM and Wyper DJ (to be published) The cerebrospinal fluid pulse pressure and the intracranial volume-pressure relationships. J Neurol Neurosurg PsychiatGoogle Scholar
- 2.Eijndhoven JHM Van, Avezaat CJJ (this volume) The analogy between CSF pulse pressure and volume-pressure response. Intracranial Pressure IVGoogle Scholar