Effect of Infusion Rate of Glycerol, Mannitol and Urea on Regional Brain Dehydration in the Rat

  • S. R. Nelson
  • C. A. Conry
Conference paper


Hyperosmotic diuretics continue to be used in patients where rapid, predictable brain dehydration is essential; however, short duration of action and side effects limit their use. Optimal infusion rates of these agents may extend the duration of action of these agents. In this report the results of studies correlating infusion rate and brain dehydration are presented. Normal rats were used because, in injured brain, osmotic diuretics appear to dehydrate those areas with normal capillary permeability (1).


Infusion Rate Volume Decrease Infusion Period Osmotic Diuretic Great Dehydration 
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  1. 1.
    Clasen RA, Cooke PM, Pandolfe S, Carnecki G, Bryar G (1965) Hypertonic urea in experimental cerebral edema. Arch Neurol 12:424–434PubMedGoogle Scholar
  2. 2.
    Klatzo I (1968) Aspects of the blood-brain barrier in brain edema. Clin Neurosurg 16:472–473Google Scholar
  3. 3.
    Nelson SR, Mantz ML, Maxwell JS (1971) Use of specific gravity in the measurement of cerebral edema. J Appl Physiol 30:268–271PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • S. R. Nelson
  • C. A. Conry

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