Effect of Infusion Rate of Glycerol, Mannitol and Urea on Regional Brain Dehydration in the Rat
Hyperosmotic diuretics continue to be used in patients where rapid, predictable brain dehydration is essential; however, short duration of action and side effects limit their use. Optimal infusion rates of these agents may extend the duration of action of these agents. In this report the results of studies correlating infusion rate and brain dehydration are presented. Normal rats were used because, in injured brain, osmotic diuretics appear to dehydrate those areas with normal capillary permeability (1).
KeywordsPermeability Catheter Glycerol Hydration Urea
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