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Monoamine Oxidase Inhibitors as Antidepressants

  • N. S. Kline
  • T. B. Cooper
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 55 / 1)

Abstract

The history of monoamine oxidase inhibitor (MAOI) use in psychiatry is a curious one and far from complete. The inspiration for our own use derived from the work of Chessin et al. (1956) who found that “marsalinizing” (treating with Marsilid, i.e., iproniazid) an animal before administering reserpine produced a paradoxical effect1. The animal rather than becoming sedated became hyperalert and active. Scott described these findings during a visit to Warner Laboratories as part of a discussion which dealt with the mode of action of reserpine. The possibility of using this combination to activate retarded schizophrenic patients and to treat depression suggested itself.

Keywords

Depressed Patient Monoamine Oxidase Biogenic Amine Monoamine Oxidase Inhibitor Broad Bean 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • N. S. Kline
  • T. B. Cooper

There are no affiliations available

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