Abstract
Myocardial ischaemia leads to anaerobic glycolysis with lactate release from the myocardium contrasting with lactate utilisation by the normally oxygenated heart (1–3). Lactate production, shown very frequently during pacing-induced angina, is not demonstrable during exertional angina, since metabolic evidence of ischaemia is obscured by elevated arterial lactate concentrations (4 and 5). Anaerobic glycolysis has been shown to be accompanied by a decrease in the myocardial tissue content of the high-energy phosphates adenosine triphosphate and creatine phosphate (6 and 7). In animals, after temporary coronary occlusion both an increase in myocardial tissue content (7–9) and a coronary venous release of the diffusible ATP catabolites adenosine, inosine, and hypoxanthine have been shown (10–12).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
HERMAN, M.V., ELLIOT, W.C., GORLIN, R.: An electrocardiographic, anatomic and metabolic study of zonal myocardial ischaemia in coronary heart disease. Circulation 35, 834 (1967)
PARKER, J.Q., CHIONG, M.A., WEST, R.Q., CASE, R.B.: Sequential alterations in myocardial lactate metabolism, s-t segments and left ventricular function during angina induced by atrial pacing. Circulation 40, 113 (1969)
OWEN, P., THOMAS, M., JOUNG, V., OPIE, L.: Comparison between metabolic changes in local venous and coronary sinus blood after acute experimental coronary arterial occlusion. Am. J. Cardiol. 25, 562 (1970)
BOURASSA, U.G., CAMPEAU, L., BOIS, M.A., RICO, O.: Myocardial lactate metabolism at rest and during exercise in ischaemic heart disease. Am. J. Cardiol. 23, 771 (1969)
PARKER, J.Q., WEST, R.O., CASE, R.B., CHIONG, M.A.: Temporal relationships of myocardial lactate metabolism, left ventricular function, and s-t-segment depression during angina precipitated by exercise. Circulation 40, 97 (1969)
GUDBJARNASON, S.: Acute alterations in energetics of ischaemic heart muscle. Cardiology 56, 232 (1971)
KÜBLER, W., SPIECKERMANN, P.G.: Changes in glycolysis and in high-energy phosphates during myocardial ischaemia with intermittent coronary perfusion. Cardiology 56, 100 (1971)
OLSSON, R.A.: Changes in content of purine nucleoside in canine myocardium during coronary occlusion. Circ. Res. 26, 301 (1970)
OLSSON, R.A., SNOW, J.A., GENTRY, M.K., FRICK, G.P.: Adenosine uptake by canine heart. Circ. Res. 31, 767 (1972)
RUBIO, R., BERNE, R.M., KATORI, M.: Release of adenosine in reactive hyperemia of the dog heart. Am. J. Physiol. 216, 56 (1969)
DOBSON, J.G., RUBIO, R., BERNE, R.M.: Role of adenosine nucleotides, adenosine and inorganic phosphates in the regulation of skeletal muscle blood flow. Circ. Res. 29, 375 (1971)
DE JONG, J.W., GOLDSTEIN, S.: Changes in coronary venous inosine concentration and myocardial wall thickening during regional ischaemia in the pig. Circ. Res. 35, 111 (1974)
FOX, A.C., REED, G.E., GLASSMANN, E., KALTMANN, A.J.: Release of adenosine from human hearts during angina induced by rapid atrial pacing. J. Clin. Invest. 53, 1447 (1974)
REMME, W.J., DE JONG, J.W., VERDOUW, P.D.: Effects of pacing-induced myocardial ischemia on hypoxanthine efflux from the human heart. Am. J. Cardiol. 40, 55 (1977)
KUGLER, G.: Myocardial release of inosine, hypoxanthine and lactate during pacing-induced angina in humans with coronary disease. Eur. J. Cardiol. 9, 227 (1979)
KUGLER, G.: The effect of nitroglycerin on myocardial release of inosine, hypoxanthine and lactate during pacing-induced angina. Basic. Res. Cardiol. 73, 523 (1978)
KUGLER, G.: A column chromatographic method for determination of plasma and erythrocyte levels of inosine and hypoxanthine. Anal. Biochem. 90, 204 (1978)
GORLIN, R.: Assessment of hypoxia in the human heart. Cardiology 57, 24 (1972)
OPIE, L.H., OWEN, P., THOMAS, M., SAMSON, R.: Coronary sinus lactate measurements in assessment of myocardial ischaemia. Am. J. Cardiol. 32, 295 (1973)
KÜBLER, W.: Myocardial energy metabolism in patients with ischemic heart disease. Basic Res. Cardiol. 69, 105 (1974)
BRACHFELD, N.: Characterization of the ischemic process by regional metabolism. Am. J. Cardiol. 37, 467 (1976)
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Kugler, G. (1980). Myocardial Release of Lactate, Inosine, and Hypoxanthine During Atrial Pacing- and Exercise-Induced Angina. In: Moret, P.R., Weber, J., Haissly, JC., Denolin, H. (eds) Lactate. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67525-6_27
Download citation
DOI: https://doi.org/10.1007/978-3-642-67525-6_27
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-09829-4
Online ISBN: 978-3-642-67525-6
eBook Packages: Springer Book Archive