Zusammenfassung
Die Synthese, Speicherung und Ausschüttung von Peptiden durch Nervenzellen ist bekannt seit der Erforschung eines Vorgangs, der mit “Neu- rosekretion” bezeichnet wird (1): Neurone, die im Hypothalamus ihren Ausgangspunkt haben, erreichen mit ihren Axonen den Hypophysenhinterlappen und bewirken, daß von hier aus Peptid-Hormone (Antidiuretisches Hormon (ADH) und Oxytozin) in den Blutkreislauf freigesetzt werden. Im Hypophysenvorderlappen werden die sezernierten Hormone lokal gebildet. Hier greifen im Hypothalamus gebildete Peptide (“releasing- und in-hibiting factors”) regulierend in die Ausschüttung der Peptidhormone ein.
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Literatur
Bargmann W, Scharrer B (1951) The Site Of Origin Of The Hormones Of The Posterior Pituitary. Am Sei 39: 255–259
Kosterlitz H, Hughes J, Lord J, Waterfield A (1977) Enke Phalins, Endorphins And Opiate Receptors. In: Approaches To The Cell Biology Of Neurons. Society For Neuroscience Symposia, Vol Ii. Cowan Fersndelli (Eds). Society For Neuroscience, Bethesda, MaryLand, Pp 291–307
Wied D (1977) Peptides And Behavior. Life Sei 20: 195–204
Renaud L (1977) Trh, Lhrh, And Somatostatin: Distribution And Physiological Action In Neural Tissue. In: Gowan Wm, Ferendelli Ja (Eds) Soeiety For Neuroscience, Bethesda Maryland, Pp 265–290
Phillis J (1977) Substance P And Related Peptides. In: Cowän Wm, Ferrndelli Ja (Eds) Approaches To The Cell Biology Of Neurones. Neuroscience Symposia Vol Ii. Society For Neuroscience, Bethesda, Maryland, Pp 241–264
Hekfelt T, Elde R, Johansson O, Ljungdahl A, Schultzberg M, Fuxe K, Goldstein M, Nilsson G, Pernow B, Terenius L, Ganten D, Jeffcoate Sl, Rehfeld J, Said S (1978) Distribution Of Peptide-Containing Neurons. In: Lipton Ma, Dimascio A, Killam Kfk (Eds) Psychopharma- Cology: A Generation Of Progress. Raven Press, New York, Pp 39–65
Hekfelt T, Elde R, Fuxe K, Johansson 0, Ljungdahl H, Goldstein M, Luft R, Efendic S, Nilsson G, Terenius L, Ganten D, Jeffcoate S, Rehfeld J, Said S, Perez Mora M, Possani L, Tapia R, Teran L, Palacios R (1973) Aminergic And Peptidergic Pathways In The Nervous System With Special Reference To The Hypothalamus. In: Reichlin S, Baldessarini Rj, Martin Jb (Eds) Hypothalamus. Raven Press New York Pp 69–136
Peach M (1977) Renin-Angiotensin System: Biochemistry And Mechanism Of Action. Physiol Rev 57 (2): 313–370
Bing J, Eskildsen Pc, Faarup P, Frederiksen O (1967) Location Of Renin In Kidneys And Extrarenal Tissues. Circ Res 20/21: Suppl Ii, 3–13
Ganten D, Schelling P, Vecsei P, Ganten U (1976) Iso-Renin Of Extra-Renal Origin. The Tissue Angiotensinogenase Systems. Am J Med 60: 760–772
Ganten D, Minnich J, Granger P, Hayduk K, Brecht H, Barbeau A, Boucher R, Genest J (1971) Angiotensin-Forming Enzyme In Brain Tissue. Science 173: 64–65
Printz M, Printz J, Gregory T (1978) Identification Of Angio-Tensinogen In Animal Brain Homogenates. Relationship To A Possible Angiotensin I - Generating Pathway. Circ Res 43 (I): 21–27
Printz M, Lewicki L (1977) Renin Substrate In The Cns: Potential Significance To Central Regulatory Mechanisms. In: Buckley Jp, Ferrario C (Eds) Central Actions Of Angiotensin And Related Hormones. Pergamon Press, New York, Pp 57–64
Ganten D, Fuxe K, Phillips M, Mann J, Ganten U The Brain Iso- Renin- Angiotensin System: Biochemistry, Localisation And Possible Role In Drinking And Blood Pressure Regulation. In: Ganong Wf, Martini L (Eds) Frontiers In Neuroendocrinology, Vol 5. Raven Press, New York, Pp 61–99
Reid L (1977) Is There A Brain Renin-Angiotensin System? Circ Res 41 (2): 147–153
Reid L, Day R (1977) Interactions And Properties Of Some Compo-Nents Of The Renin-Angiotensin System In Brain. In: Buckley Jp, Ferrario C (Eds) Central Actions Of Angiotensin And Related Hor-Mones. Pergamon Press, New York Pp 267–282
Ganten D, Marquez-Julio A, Granger P, Hayduk K, Karsunky K, Boucher R, Genest J (1971) Renin In Dog Brain. Am J Physiol 221: 1733–1737
Fischer-Ferraro C, Nahmod V, Goldstein D, Finkielman S (1971) Angiotensin And Renin In Rat And Dog Brain. J Exp Med 133 (2): 353–361
Hirose S, Yokosawa H, Inagami T (1978) Immunochemical Identification Of Renin In Rat Brain And Distinction From Acid Proteases. Nature 274: 392–393
Osman M, Sen S, Smeby R (1978) Separation Of Renin Activity From Acid Protease Activity In Brain Extracts. Fed Proc 37 (3): Abstract No 760
Ganten D, Speck G (1978) The Brain Renin-Angiotensin System: A Model For The Synthesis Of Peptides In The Brain. Biochem Pharmacol 27: 2379–2389
Hutchinson J, Scicsman J, Korner P, Johnston C (1978) Characteri-Zation Of Immunoreactive Angiotensin In Canine Cerebrospinal Fluid As Des-Asp1-Angiotensin Ii. Clin Sei Mol Med 54: 147–151
Bennet J, Snyder S (1976) Angiotensin Ii Binding To Mammalian Brain Membranes. J Biol Chem 251 (23): 7423–7430
Sirett N, Mclean A, Bray J, Hubbard J (1977) Distribution Of Angiotensin Ii Receptors In Rat Brain. Brain Res 122: 299–312
Mann J, Rascher W, Dietz R, Schemig A, Ganten D (1978) Effects Of An Orally Active Converting-Enzyme Inhibitor, Sq 14225, On Pressor Responses To Angiotensin Administered Into The Brain Ventricles Of Spontaneously Hypertensive Rats. Clin Sei Mol Med, In Vorbereitung
Schelling P, Hutchinson J, Ganten U, Sponer G, Ganten D (1976) Impermeability Of The Blood-Cerebrospinal Fluid Barrier For Angio-Tensin Ii In Rats. Clin Sei Mol Med 51: 399S–402S
Ferrario C, Gildenberg P, Mecubbin J (1972) Cardiovascular Effects Of Angiotensin Mediated By The Central Nervous System. Circ Res 30 (3): 257–262
Keil L, Summy-Long J, Severs W (1975) Release Of Vasopressin By Angiotensin Ii. Endocrinology 96: 1063–1065
Severs W, Severs A (1973) Effects Of Angiotensin On The Central Nervous System. Pharmacol Rev 25 (4): 415–449
Ganten D, Stock G (1978) Humoral And Neurohormonal Aspects Of Blood Pressure Regulation: Focus On Angiotensin. Kli Woehenschr, In Press
Phillips M, Felix D (1976) Specific Angiotensin Il-Respective Neurons In The Eat Subfornical Organ. Brain Res 109: 531–540
Sakai K, Marks B, George J, Kostner A (1974) Specific Angiotensin Ii Receptors In Organ-Cultured Canine Supra-Optic Nucleus Cells. Life Sei 14: 1337–1344
Epstein A (1978) The Neuroendocrinology Of Thirst And Salt Appetite. In: Fanong Wf, Martini L (Eds) Frontiers In Neuroendocrinology, Vol 5. Raven Press, New York, Pp 101–134
Johnson A, Buggy J (1977) A Critical Analysis Of The Site Of Action For The Dipsogenic Effect Of Angiotensin Ii. In: Buckley Jp, Ferrario C (Eds) Central Actions Of Angiotensin And Related Hormones. Raven Press, New York, Pp 357–386
Ree J, Bohus B, Versteeg D, Wied D (1978) Neurohypophyseal Principles And Memory Processes. Biochem Pharmacol 27: 1793–1800
Morgan J, Routtenberg A (1977) Angiotensin Injected Into The Neo-Striatum After Learning Disrupts Retention Performance. Science 196: 87–89
Keller M, Krause D, Hoffmeister F, Ganten D: Manuskript In Vorbe-Reitung
Oliveros J, Jandali M, Timsit-Berthier M, Remy R, Benghezal A, Audibert A, Moeglen J (1978) Vasopressin In Amnesia. Lancet I: 42
Thurau K (1974) Intrarenal Actions Of Angiotensin. In: Page Ih, Bumpus Fm (Eds) Handbook Of Experimental Pharmacology, Vol Xxxvii. Springer, Berlin Heidelberg New York, Pp 475–499
Guillemin R (1978) Biochemical And Physiological Correlates Of Hypothalamic Peptides. The New Endocrinology Of The Neuron. In: Reichlin S, Baldessarini Rj, Martin Jb (Eds) The Hypothalamus. Raven Press, New York, Pp 155–194
Mann J, Phillips M, Dietz R, Haebara H, Ganten D (1978) Effects Of Central And Peripheral Angiotensin Blockade In Hypertensive Rat. Am J Physiol 234 (5): H629–H637
Schoelkens B, Jung W, Steinbach R (1976) Blood Pressure Response To Central And Peripheral Injection Of Angiotensin Ii And 8-C- Phenylglycine Analogue Of Angiotensin Ii In Rats With Experimental Hypertension. Clin Sei Mol Med 51: 403S–406S
Hoffman W, Ganten U, Phillips M, Schmid P, Schelling P, Ganten D (1978) Inhibition Of Drinking In Water-Deprived Rats By Combined Central Angiotensin Ii And Cholinergic Receptor Blockade. Am J Physiol 234 (1): F41–F47
Malvin R, Mouw D, Vander A (1977) Angiotensin: Physiological Role In Water Deprivation-Induced Thirst Of Rats. Science 197: 171–173
Simon W, Schaz K, Ganten U, Stock G, Schler K, Ganten D (1978) Effects Of Enkephalins On Arterial Blood Pressure Are Reduced By Propranolol. Clin Sei Mol Med, In Press
Schaz K, Simon W, Ganten D: Manuskript In Vorbereitung
Benuck M, Grynbaum A, Cooper T, Marks N (1978) Conversion Of Lipotropic Peptides By Purified Cathepsin D Of Huma Pituitary: Release Of Endorphin By Cleavage Of The Leu77-Phe Bond. Neurosci Lett 10: 3–9
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Ungar, T., Speck, G., Ganten, D. (1980). Das Gehirn Renin-Angiotensin System: Ein Modell für die Synthese von Peptiden im Gehirn. In: Schiffter, R. (eds) Zentral-vegetative Regulationen und Syndrome. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67524-9_7
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