Plasma Concentrations and Comparative Bioavailability of Bemetizide and Triamterene in Combination

Abstract

Thiazide diuretics such as bemetizide (Fig. 1) and the potassium-sparing triamterene (Fig. 1) have been in clinical use for several years but it is only recently that pharmacokinetic data on these compounds have become available. A major reason for this is the increasing awareness of the usefulness of pharmacokinetic data and of the availability of adequately sensitive and specific methods for the measurement of these drugs in biological fluids.