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Adrenergic Activators and Inhibitors pp 823–852Cite as

Effects on Myocardial Metabolism

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 54 / 1))

Abstract

The metabolic consequences of the actions of catecholamines on the heart have been excellently reviewed by Himms-Hagen in Vol. XXXIII. of this Handbook (Himms- Hagen, 1972). Therefore, the effects of adrenergic agonists on heart metabolism will be discussed rather briefly and attention will be focussed on new problems which have arisen and are under investigation. Progress during the last years consists of better knowledge of the molecular nature of the processes which originate on the cell surface membrane by interaction of adrenergic agonists with their specific receptors and which terminate in a modified physiological response. The first series of the cascading chain reactions which result in an increased intracellular level of cyclic AMP is based on the “second messenger” concept postulated by Sutherland and co-workers (Sutherland and Rall, 1960; Sutherland et al., 1965; Sutherland and Robison, 1966; Sutherland et al., 1968). The role of cyclic AMP in mediating metabolic and physiological effects of catecholamines, which represent the naturally occurring class of adrenergic agonists, is now clearer. However, it is far from being completely understood. Recently published results of Ingebretsen et al., Becker et al., and Hu and Venter have demonstrated that catecholamines covalently bound to glass beads or polymers are able to induce metabolic and physiological effects comparable to those of solubilized amines without, however, raising the intracellular level of cyclic AMP (Ingebretsen et al., 1977; Becker et al., 1977; Hu and Venter, 1978). How the signal originating from interaction of catecholamines with the β-adrenergic receptor is propagated is obscure and has still to be clarified.

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  1. L. Will-Sahab
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  2. E. G. Krause
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  1. Institute of Pharmacology, University Medical School of Szeged, Dóm tér 12, H-6701, Szeged, Hungary

    Lászlo Szekeres

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Will-Sahab, L., Krause, E.G. (1980). Effects on Myocardial Metabolism. In: Szekeres, L. (eds) Adrenergic Activators and Inhibitors. Handbook of Experimental Pharmacology, vol 54 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67505-8_20

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