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Catecholamines and the Regulation of Body Temperature

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Adrenergic Activators and Inhibitors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 54 / 1))

Abstract

It is clear now that the two principal components of an animal’s temperature regulating capacity — central and peripheral — utilize catecholaminergic mechanisms. What is biologically so fascinating is the entirely different way in which a given catecholamine acts. On the one hand, central noradrenergic neurons are involved in the complicated activation of the processes underlying heat dissipation. But peripherally, the adrenergic principle is involved in the thermogenesis required for the defense against a cold environment. In this chapter, some of the principal findings will be presented that have provided the specific evidence upon which these viewpoints are now based.

The research by the author reported in this chapter has been supported over the years by grants from the National Science Foundation and by contracts from the U.S. Office of Naval Research.

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References

  • Andersson, B., Gale, C.C., Hokfelt, B., Ohga, A.: Relation of preoptic temperature to the function of the sympathico-adrenomedullary system and the adrenal cortex. Acta Physiol. Scand. 61, 182–191 (1963)

    Google Scholar 

  • Avery, D.D.: Thermoregulatory effects of intrahypothalamic injections of adrenergic and cholinergic substances at different environmental temperatures. J. Physiol. 220, 257–266 (1972)

    PubMed  CAS  Google Scholar 

  • Baldwin, B.A., Ingram, D.L., LeBlanc, J.: The effects of environmental temperature and hypothalamic temperature on excretion of catecholamines in the urine of the pig. Brain Res. 16, 511–515 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Barbour, H.G., Wing, E.S.: The direct application of drugs to the temperature centers. J. Pharmacol. 5, 105–147 (1913)

    Google Scholar 

  • Barnett, A., Goldstein, J., Taber, R.I.: Apomorphine-induced hypothermia in mice; a possible dopaminergic effect. Arch. Int. Pharmacodyn. Ther. 198, 242–247 (1972)

    PubMed  CAS  Google Scholar 

  • Breese, G.R., Howard, J.L.: Effect of central catecholamine alterations on the hypothermic response to 6-hydroxydopamine in desipramine treated rats. Br. J. Pharmacol. 46, 671–674 (1971)

    Google Scholar 

  • Breese, G.R., Moore, R.A., Howard, J.L.: Central actions of 6-hydroxydopamine and other phenylthylamine derivatives on body temperature in the rat. J. Pharmacol. Exp. Ther. 180, 591–602 (1972)

    PubMed  CAS  Google Scholar 

  • Brodie, B.B., Maickel, R.P., Stern, D.N.: Autonomic nervous system and adipose tissue. In: Handbook of physiology. Renold, A.E., Cahill, G.F. Jr. (eds.), pp. 583–600. Washington (D.C.): American Physiological Society 1965

    Google Scholar 

  • Brück, K.: Temperature regulation and catecholamines. Isr. J. Med. Sci. 12, 924–933 (1976)

    PubMed  Google Scholar 

  • Burks, T.F.: Central alpha adrenergic receptors in thermoregulation. Neuropharmacology 11, 615–624 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Cantor, A., Satinoff, E.: Thermoregulatory responses to intraventricular norepinephrine in normal and hypothalamic-damaged rats. Brain Res. 108, 125–141 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Carlson, L.D.: Nonshivering thermogenesis and its endocrine control. Fed. Proc. 19 [Suppl. 5], 25–30 (1960)

    PubMed  Google Scholar 

  • Carlson, L.D.: The role of catecholamines in cold adaptation. Pharmacol. Rev. 18, 291–301 (1966)

    PubMed  CAS  Google Scholar 

  • Chaffee, R.R.J., Roberts, J.C.: Temperature acclimation in birds and mammals. Annu. Rev. Physiol. 33, 155–202 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Chevillard, L., Portet, R., Cadot, M., Cabady, M.: Effet de la réserpine sur les échanges respiratoires, la pression artérielle et le rythme cardiaque du rat adapté a basse temperature. Arch. Int. Pharmacodyn. 153, 30–49 (1965)

    CAS  Google Scholar 

  • Cooper, K.E., Jones, D.L., Pittman, Q.J., Veale, W.L.: The effect of noradrenaline, injected into the hypothalamus, on thermoregulation in the cat. J. Physiol. 261, 211–222 (1976)

    PubMed  CAS  Google Scholar 

  • Coper, H., Lison, H., Rommelspacher, H., Schulze, G., Strauß, S.: The influence of adrenergic receptor-blocking agents, amphetamine, and 6-aminonicotinamide on thermoregulation. Naunyn-Schmiedebergs Arch. Pharmakol. 270, 378–391 (1971)

    CAS  Google Scholar 

  • Corrodi, H., Fuxe, K., Hökfelt, T.: A possible role played by central monoamine neurones in thermo-regulation. Acta Physiol. Scand. 71, 224–232 (1967)

    Article  CAS  Google Scholar 

  • Cox, B., Tha, S.J.: The role of dopamine and noradrenaline in temperature control of normal and reserpine-pretreated mice. J. Pharm. Pharmacol. 27, 242–247 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Cranston, W.I., Rosendorff, C.: Acute effects of a monoamine oxidase inhibitor, tranylcypromine, on thermoregulation in the conscious rabbit. Br. J. Pharmacol. 38, 530–536 (1970)

    PubMed  CAS  Google Scholar 

  • Cranston, W.I., Hellon, R.F., Luff, R.H., Rawlins, M.D.: Hypothalamic endogenous noradrenaline and thermoregulation in the cat and rabbit. J. Physiol. 223, 59–67 (1972)

    PubMed  CAS  Google Scholar 

  • Depocas, F.: The calorigenic response of cold-acclimated white rats to infused noradrenaline. Can. J. Biochem. 38, 107–114 (1960)

    Article  PubMed  CAS  Google Scholar 

  • Doggett, N.S., Reno, H., Spencer, P.S.J.: The effect of drugs with antidepressant activity upon the hypothermia and behavioural depression induced in mice by pimozide or centrally administered noradrenaline. Neuropharmacology 14, 85–90 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Feist, D.D.: Effects of cold exposure on urinary and adrenal catecholamines in a hibernator, the golden hamster. Comp. Biochem. Physiol. 42 A, 883–840 (1972)

    Google Scholar 

  • Feldberg, W., Lotti, V.J.: Temperature respones to monoamines and an inhibitor of MAO injected into the cerebral ventricels of rats. Br. J. Pharmacol. Chemother. 31, 152–161 (1967)

    PubMed  CAS  Google Scholar 

  • Feldberg, W., Myers, R.D.: A new concept of temperature regulation by amines in the hypothalamus. Nature 200, 1325 (1963)

    Article  PubMed  CAS  Google Scholar 

  • Feldberg, W., Myers, R.D.: Temperature changes produced by amines injected into the cerebral ventricles during anaesthesia. J. Physiol. 175, 464–478 (1964)

    PubMed  CAS  Google Scholar 

  • Feldberg, W., W. Myers, R.D.: Changes in temperature produced by microinjections of amines into the anterior hypothalamus of cats. J. Physiol. 177, 239–245 (1965)

    PubMed  CAS  Google Scholar 

  • Feldberg, W., Saxena, P.N.: Effects of adrenoceptor blocking agents on body temperature. Br. J. Pharmacol. 43, 543–554 (1971)

    PubMed  CAS  Google Scholar 

  • Fregly, M.J., Field, F.P., Nelson, E.L., Jr., Tyler, P.E., Dasler, R.: Effect of chronic exposure to cold on some responses to catecholamines. J. Appl. Physiol. 42, 349–354 (1977)

    PubMed  CAS  Google Scholar 

  • Frey, H.-H.: Hyperthermia induced by amphetamine, chloroamphetamine and fenfluramine in the rat. Pharmacology 13, 163–176 (1975)

    Article  CAS  Google Scholar 

  • Gardey-Levassort, C., Sohlberg, S.-A., Lechat, P.: Comparaison des effects de deux inhibiteurs de la dopamine β-hydroxylase sur les catécholamines hypothalaminiques température centrale du lapin. J. Pharmacol. (Paris) 7, 341–354 (1976)

    Google Scholar 

  • Gessa, G.L., Clay, G.A., Brodie, B.B.: Evidence that hyperthermia produced by d-amphetamine is caused by a peripheral action of the drug. Life Sci. 8, 135–141 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Gessner, P.K., Clarke, C.C.: The effects of meperidine and dextromethorphan on thermoregulation in mice. In: Temperature regulation and drug action. Lomax, P., Schonbaum, E., Jacob, J. (eds.), pp. 266–273. Basel: Karger 1975

    Google Scholar 

  • Gonzales, R.R.: Thermoregulatory responses to norepinephrine after inhibition of its synthesis in rabbits. J. Appl. Physiol. 33, 341–345 (1972)

    Google Scholar 

  • Gordon, R., Spector, S., Sjoerdsma, A., Udenfriend, S.: Increased synthesis of norepinephrine and epinephrine in the intact rat during exercise and exposure to cold. J. Pharmacol. Exp. Ther. 153, 440–447 (1966)

    PubMed  CAS  Google Scholar 

  • Grabowsky, M., Andén, N.-E.: Apomorphine in the rat nucleus accumbens: effects on the synthesis of 5-hydroxytryptamine and noradrenaline, the motor activity and the body temperature. J. Neural Transm. 38, 1–8 (1976)

    Article  Google Scholar 

  • Hayward, J.N., Baker, M.A.: Diuretic and thermoregulatory responses to preoptic cooling in the monkey. Am. J. Physiol. 214, 843–850 (1968)

    PubMed  CAS  Google Scholar 

  • Himms-Hagen, J.: Sympathetic regulation of metabolism. Pharmacol. Rev. 19, 367–461 (1967)

    PubMed  CAS  Google Scholar 

  • Hissa, R., Rautenberg, W.: The influence of centrally applied noradrenaline on shivering and body temperature in the pigeon. J. Physiol. 238, 421–435 (1974)

    Google Scholar 

  • Horita, A., Hill, H.F.: Hallucinogens, amphetamines and temperature regulation. In: The pharmacology of thermoregulation. Schönbaun, E., Lomax, P. (eds.), pp. 417–431 Basel: Karger 1973

    Google Scholar 

  • Jacobowitz, D.M., Palkovits, M.: Topographic atlas of catecholamine and acetylcholin- esterase-containing neurons in the rat brain. 1. Forebrain (telencephalon, diencephalon). J. Comp. Neurol 157, 13–28 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Janský, L.: Non-shivering thermogenesis and its thermoregulatory significance. Biol. Rev. 48, 85–132 (1973)

    Article  PubMed  Google Scholar 

  • Janksý, L., Bartunkova, R., Kockova, J., Mejsnar, J., Zeisberger, E.: Interspecies differences in cold adaptation and nonshivering thermogenesis. Fed. Proc. 28, 1053–1058 (1969)

    Google Scholar 

  • Jellinek, P.: Dual effect of dexamphetamine on body temperature in the rat. Eur. J. Pharmacol. 15, 389–392 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Johnson, G.E., Schönbaum, E., Sellers, E.A.: Cold exposure: pharmacologic investigation of the compensatory mechanisms in the maintenance of normothermia. Fed. Proc. 25, 1216–1219 (1966)

    PubMed  CAS  Google Scholar 

  • Kennedy, M.S., Burks, T.F.: Central adrenergic mediation of tyramine hypothermia in cats. Res. Commun. Chem. Pathol. Pharmacol. 3, 1–14 (1972)

    PubMed  CAS  Google Scholar 

  • Kennedy, M.S., Burks, T.F.: Dopamine receptors in the central thermoregulatory mechanism of the cat. Neuropharmacology 13, 119–128 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Kostrzewa, R.M., Jacobowitz, D.M.: Pharmacological actions of 6-hydroxydopamine. Pharmacol. Rev. 26, 199–288 (1974)

    PubMed  CAS  Google Scholar 

  • Kruk, Z.L.: The effect of drugs acting on dopamine receptors on the body temperature of the rat. Life Sci. 11, 845–850 (1972)

    Article  CAS  Google Scholar 

  • Lagerspetz, K.Y.H.: Temperature acclimation and the nervous system. Biol. Rev. 49, 477–514 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Leblanc, J.: Effects of reserpine on increased sensitivity to noradrenaline of cold-adapted animals. J. Appl. Physiol. 21, 661–664 (1966)

    PubMed  CAS  Google Scholar 

  • Leblanc, J., Villemaire, A.: Thyroxine and noradrenaline on noradrenaline sensitivity, cold resistance, and brown fat. Am J. Physiol. 218, 1742–1745 (1970)

    PubMed  CAS  Google Scholar 

  • Leduc, J.: Effect of exposure to cold on the production and release of catecholamines. Acta Physiol. Scand. 53 [Suppl. 183], 18–38 (1961)

    Google Scholar 

  • Maeda, T., Shimizu, N.: Projections ascendantes du locus coeruleus et d’autres neurones aminergiques pontiques au niveau du prosencéphale du rat. Brain Res. 36, 19–35 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Metcalf, G., Myers, R.D.: Precise location within the preoptic area where noradrenaline produces hypothermia. Eur. J. Pharmacol. 51, 47–53 (1978)

    Article  PubMed  CAS  Google Scholar 

  • Myers, R.D.: Discussion of serotonin, norepinephrine, and fever. Adv. Pharmacol. 6, 318–321 (1968)

    Article  PubMed  CAS  Google Scholar 

  • Myers, R.D.: Temperature regulation. In: Handbook of drug and chemical stimulation of the brain. Myers, R.D. (ed.), pp. 237–301. New York: Van Nostrand Reinhold 1974

    Google Scholar 

  • Myers, R.D.: Impairment of thermoregulation, food and water intakes in the rat after hypothalamic injections of 5,6-dihydroxytryptamine. Brain Res. 94, 491–506 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Myers, R.D.: Hypothalamic control of thermoregulation: neurochemical mechanisms. In: Handbook of the hypothalamus, edited by Morgane, P., Panksepp, J., New York: Marcel Dekker (in press) (1980)

    Google Scholar 

  • Myers, R.D., Chinn, C.: Evoked release of hypothalamic norepinephrine during thermoregulation in the cat. Am J. Physiol. 224, 230–236 (1973)

    PubMed  CAS  Google Scholar 

  • Myers, R.D., Ruwe, W.D.: Thermoregulation in the rat: deficits following 6-OH-DA injections in the hypothalamus. Pharmacol. Biochem. Behav. 8, 337–385 (1978)

    Article  Google Scholar 

  • Myers, R.D., Waller, M.B.: Species continuity in the thermoregulatory responses of the pigtailed macaque to monoamines injected into the hypothalamus. Comp. Biochem. Physiol. 51 A, 639–645 (1975)

    Google Scholar 

  • Myers, R.D., Yaksh, T.L.: Feeding and temperature responses in the unrestrained rat after injections of cholinergic and aminergic substances into the cerebral ventricles. Physiol. Behav. 3, 917–928 (1969)

    Article  Google Scholar 

  • Myers, R.D., Yaksh, T.L.: Control of body temperature in the unanaesthetized monkey by cholinergic and aminergic systems in the hypothalamus. J. Physiol. 202, 483–500 (1969)

    PubMed  CAS  Google Scholar 

  • Nakamura, K., Thoenen, H.: Hypothermia induced by intraventricular administration of 6-hydroxydopamine in rats. Eur. J. Pharmacol. 16, 46–54 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Nistico, G., Marley, E.: Neurotrasmettitori e termoregolazione. Acta Neurol. 33, 5–50 (1974)

    Google Scholar 

  • Olson, L., Fuxe, K.: On the projections from the locus coeruleus noradrenaline neurons: the cerebellar innervation. Brain Res. 28, 165–171 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Palkovits, M., Brownstein, M., Saavedra, J.M., Axelrod, J.: Norepinephrine and dopamine content of hypothalamic nuclei of the rat. Brain Res. 77, 137–149 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Pittmann, Q.J., Veale, W.L., Cooper, K.E.: Effect of prostaglandin, pyrogen and noradrenaline, injected into the hypothalamus, on thermoregulation in newborn lambs. Brain Res. 128, 473–483 (1977)

    Article  Google Scholar 

  • Preston, E.: Thermoregulation in the rabbit following intracranial injection of norepinephrine. Am. J. Physiol. 229, 676–682 (1975)

    PubMed  CAS  Google Scholar 

  • Quock, R.M., Gale, C.C.: Hypothermia-mediating dopamine receptors in the preoptic anterior hypothalamus of the cat. Naunyn-Schmiedebergs Arch. Pharmacol. 285, 297–300 (1974)

    CAS  Google Scholar 

  • Reid, J.L., Lewis, P.J., Myers, M.G.: Role of central dopaminergic mechanisms in piribedil and Clonidine induced hypothermia in the rat. Neuropharmacology 14, 215–220 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Rudy, T.A., Wolf, H.H.: The effect of intrahypothalamieally injected sympathomimetic amines on temperature regulation in the cat. J. Pharmacol. Exp. Ther. 179, 218–235 (1971)

    PubMed  CAS  Google Scholar 

  • Ruwe, W.D.: Diencephalic mediation of thermoregulation and feeding in the cat by a dopaminergic mechanism. Purdue University. Master’s thesis 1977

    Google Scholar 

  • Ruwe, W.D., Myers, R.D.: Dopamine in the hypothalamus of the cat: Pharmacological characterization and push-pull perfusion analysis of sites mediating hypothermia. Pharmacol. Biochem. Behav. 9, 65–80 (1978)

    Article  PubMed  CAS  Google Scholar 

  • Saxena, P.N.: Mechanism of hypothermic action of catecholamines in the cat. Ind. J. Pharmac. 5, 3–6 (1973)

    Google Scholar 

  • Schmidt, J.: Die Abhängigkeit der Temperaturbeeinflussung von Ratten durch biogene Amine von der Applikationsart und der Umgehungstemperatur. Acta Biol. Med. Ger. 10, 350–356 (1963)

    CAS  Google Scholar 

  • Shellenberger, M.K., Elder, J.T.: Changes in rabbit core temperature accompanying alterations in brainstem monoamine concentrations. J. Pharmacol. Exp. Ther. 158, 219–226 (1967)

    PubMed  CAS  Google Scholar 

  • Shellenberger, M.K., Elder, J.T.: Alterations in rabbit core temperature produced by alpha-methyl metatyrosine. Eur. J. Pharmacol. 3, 196–202 (1968)

    Article  PubMed  CAS  Google Scholar 

  • Shemano, I., Nickerson, M.: Effect of ambient temperature on thermal responses to drugs. Can. J. Biochem. Physiol. 36, 1243–1249 (1958)

    Article  PubMed  CAS  Google Scholar 

  • Shum, A., Johnson, G.E., Flattery, K.V.: Influence of ambient temperature on excretion of catecholamines and metabolites. Am. J. Physiol. 216, 1164–1169 (1969)

    PubMed  CAS  Google Scholar 

  • Simmonds, M.A.: Inhibition by atropine of the increased turnover of noradrenaline in the hypothalamus of rats exposed to cold. Br. J. Pharmacol. 42, 224–229 (1971)

    PubMed  CAS  Google Scholar 

  • Simmonds, M.A., Uretsky, N.J.: Central effects of 6-hydroxydopamine on the body temperature of the rat. Br. J. Pharmacol. 40, 630–638 (1970)

    PubMed  CAS  Google Scholar 

  • Smith, R.E., Horwitz, B.A.: Brown fat and thermogenesis. Physiol. Rev. 49, 330–425 (1969)

    PubMed  CAS  Google Scholar 

  • Somerville, A.R., Whittle, B.A.: The interrelation of hypothermia and depletion of noradrenaline, dopamine and 5-hydroxytryptamine from brain by reserpine, p-chlorophenylalanine and α-methylmetatyrosine. Br. J. Pharmacol. Chemother, 31, 120–131 (1967)

    PubMed  CAS  Google Scholar 

  • Summers, R.J.: Monoamine oxidase inhibitors and body temperature. In: The pharmacology of thermoregulation. Schonbaum, E., Lomax, P. (eds.), pp. 217–231. Basel: Karger 1973

    Google Scholar 

  • Terwelp, D.R., Kennedy, M.S., Burks, T.F.: Temperature responses to intraventricular amphetamine in unanesthetized cats. Res. Commun. Chem. Pathol. Pharmacol. 6, 795–804 (1973)

    PubMed  CAS  Google Scholar 

  • Toivola, P., Gale, C.C.: Effect on temperature of biogenic amine infusion into hypothalamus of baboon. Neuroendocrinology 6, 210–219 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Veale, W.L., Whishaw, I.Q.: Body temperature responses at different ambient temperatures following injections of prostaglandin and noradrenaline into the brain. Pharamcol. Biochem. Behav. 4, 143–150 (1976)

    Article  CAS  Google Scholar 

  • Vogt, M.: The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs. J. Physiol. 123, 451–481 (1954)

    PubMed  CAS  Google Scholar 

  • Von Euler, C.: Physiology and pharmacology of temperature regulation. Pharmacol. Rev. 13, 361–398 (1961)

    Google Scholar 

  • Williams, D.D.: The effects of cold exposure and guanethedine on norepinephrine thermogenesis in the golden hamster. Comp. Biochem. Physiol. 27, 567–573 (1968)

    Article  PubMed  CAS  Google Scholar 

  • Yaksh, T.L., Myers, R.D.: Hypothalamic “coding” in the unanesthetized monkey of noradrenergic sites mediating feeding and thermoregulation. Physiol. Behav. 8, 251–257 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Yehuda, S., Wurtman, R.J.: The effects of d-amphetamine and related drugs on colonic temperatures of rats kept at various ambient temperatures. Life Sci. 11, 851–859 (1972)

    Article  CAS  Google Scholar 

  • Zeisberger, E., Briick, K.: Alteration of shivering threshold in cold- and warm-adapted guinea pigs following intrahypothalamic injections of noradrenaline and of an adrenergic alpha- receptor blocking agent. Pflugers Arch. 362, 113–119 (1976)

    Article  PubMed  CAS  Google Scholar 

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  1. Institute of Pharmacology, University Medical School of Szeged, Dóm tér 12, H-6701, Szeged, Hungary

    Lászlo Szekeres

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Myers, R.D. (1980). Catecholamines and the Regulation of Body Temperature. In: Szekeres, L. (eds) Adrenergic Activators and Inhibitors. Handbook of Experimental Pharmacology, vol 54 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67505-8_14

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