Abstract
To detect congenital hypothyroidism (CH) during the 1st month of life prior to the development of overt clinical symptoms, we initiated a pilot study in April 1972 to determine the normal values for thyrotropin (TSH) in serum at birth and at ages 3 days and 6 weeks of life (Abuid et al. 1974). We selected the measurement of TSH in cord serum initially since TSH is the most sensitive test for primary hypothyroidism and since cord serum is the earliest specimen that is easily available from the infant. Since the onset of our cord TSH screening program in August 1973, we have reported that primary screening by the determination of TSH will successfully identify affected infants with a high index of discrimination and a low false positive recall rate (Foley et al. 1975, 1978; Klein and Foley 1975; Klein et al. 1974, 1975, 1976).
Supported in part by US Public Health Service research grant MC-R-420385, training grant HD 00227, general research support grant RR-05507, general clinical research grant 2MOI-RR-00084 and by Health Research Services Grant R-46, the Renziehausen Fund and the Press Old Newsboys Fund.
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References
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Foley, T.P. et al. (1980). Experience with Primary Thyrotropin (TSH) Screening for Congenital Hypothyroidism in Pittsburgh, Pa.. In: Bickel, H., Guthrie, R., Hammersen, G. (eds) Neonatal Screening for Inborn Errors of Metabolism. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67488-4_17
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DOI: https://doi.org/10.1007/978-3-642-67488-4_17
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