Screening for Congenital Hypothyroidism: 4 Years of Experience
Congenital hypothyroidism is almost the ideal model suited for a mass screening program. If untreated, the disease leads to irrecuperable mental and physical retardation (Raiti and Newns 1971; Klein et al. 1972); early diagnosis is difficult because of the subtle clinical signs. The incidence was thought to be important (1:5000 to 1:10 000 births) (Kenney et al. 1975), and treatment with synthetic thyroid hormones is available. Thus, one had only to develop the methodology to insure early diagnosis of the disease.
KeywordsAssure Constipation Hypoglycemia Hypothyroidism Hyperthyroidism
Unable to display preview. Download preview PDF.
- Dussault JH, Morissette J, Letarte J, Guyda H, Laberge C (to be published) A simple and rapid method to evaluate the thyroxine binding capacity and concentration from filter paper blood spots in a screening program for neonatal hypothyroidism. Clinical ChemistryGoogle Scholar
- Fisher DA (1974) Thyroid function in the neonatal period. In: Kelley VC (ed) Metabolic endocrine and genetic disorders of children. Harper Row, New YorkGoogle Scholar
- Kenney FM, Klein AH, Augustin AV, Foley TP (1975) Sporadic cretinism. In: Fisher DA, Burrow GN (eds) Perinatal thyroid physiology and disease. Raven Press, New York, p 133Google Scholar
- Letarte J, Guyda H, Dussault JH, Morissette J, Laberge C (to be published) Clinical and biochemical features of neonatal hypothyroid infants diagnosed by the Quebec Network for Genetic MedicineGoogle Scholar