Abstract
The pathogenesis and often the etiology of aplastic anemia is still obscure [1, 4, 10]. However, it is generally recognised that there is a basic defect in the pluripotent stem cell compartment which results in a diminished feeding of later, more differentiated compartments, eventually leading to a failure of the production of mature cells.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Boggs, D. R. and Boggs, S. S.: The pathogenesis of aplastic anemia: a defective pluripotent hematopoietic stem cell with inappropriate balance of differentiation and self-replication. Blood 48, 71–76 (1976)
Dexter, T. M. and Moore, M. A. S.: In vitro duplication and “cure” of haemopoietic defects in genetically anaemic mice. Nature 269, 412–413 (1977)
Hansi, W., Rich, I., Heimpel, H., Heit, W. and Kubanek, B.: Erythroid colony forming cells in aplastic anemia. Brit. J. Haemat. 37, 483–488 (1977)
Heimpel, H. and Kubanek, B.: Pathophysiology of aplastic anemia. Brit. J. Haemat. 31, (Suppl.), 57–68 (1975)
Iscove, N. N.: Erythropoietin-Independent Stimulation of Early Erythropoiesis in Adult Marrow Cultures by Conditioned Media from Lectin-Stimulated Mouse Spleen Cells. ICN-UCLA Symposium on Hemopoietic Cell Differentiation, (1978) in press
Johnson, G. R. and Metcalf, D.: Pure and mixed erythroid colony formation in vitro stimulated by spleen conditioned medium with no detectable erythropoietin. Proc. Natl. Acad. Sci USA 74, 9, 3879–3882 (1977)
Kern, P., Heimpel, H., Heit, W. and Kubanek, B.: Granulocytic progenitor cells in aplastic anemia. Brit. J. Haemat. 35, 613–623 (1977)
Micklem, H. S., Ogden, D. A. and Payne, A. C.: Ageing, Haemopoietic Stem Cells and Immunity. In: Haemopoietic Stem Cells. Ciba Foundation Symposium 13. Amsterdam: Associated Scientific Publishers, 1973, p. 285–297
Morley, A., Trainor, K. and Blake, J.: A primary stem cell lesion in experimental chronic hypoplastic marrow failure. Blood 45, 5, 681–688 (1975)
Stohlman, F., jr.: Aplastic anemia. Blood 40, 2, 282–286 (1972)
Storb, R. and Thomas, E. D.: Marrow transplantation for treatment of aplastic anemia. Clinics Haematol. 7, 3, 597–609 (1978)
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1979 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Kubanek, B. (1979). Aplastic Anemia — A Stem Cell Disorder?. In: Heimpel, H., Gordon-Smith, E.C., Heit, W., Kubanek, B. (eds) Aplastic Anemia. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 24. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67483-9_8
Download citation
DOI: https://doi.org/10.1007/978-3-642-67483-9_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-09772-3
Online ISBN: 978-3-642-67483-9
eBook Packages: Springer Book Archive