Preleukemia pp 16-22 | Cite as

Blood and Bone Marrow Follow-Up Studies on Patients with Preleukemic States — Observation of Different Phases of the Evolving Leukemic Process

  • I. Fohlmeister
  • H. E. Schaefer
  • K.-P. Hellriegel
  • R. Fischer
Conference paper


Analysis of the preleukemic state of 15 patients, 12 of whom developed acute leukemia after 4 to 54 months, showed three morphological types of the preleukemic state. Two or all of them were passed successively by our patients. Thus they represent different phases of the evolving leukemic process. The usual sequence seems to be aplastic phase, erythropoietic hyper- and dysplasia, and finally granulopoietic hyper- and dysplasia. Overt leukemia apparently develops out of either of these phases. According to our findings, the differentiation of the leukemia is the higher, and the overt leukemic phase is the longer, the earlier this takes place.

In all but one of our cases, marrow blast cells were increased during a prolonged phase preceding overt leukemia, without particular association to the different morphological marrow phases.


Acute Leukemia Bone Marrow Biopsy Blast Cell Paroxysmal Nocturnal Hemoglobinuria Bone Marrow Smear 
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  1. 1.
    Broun, G.O., Jr.: Chronic erythromonocytic Leukemia. Am. J. Med. 47, 785 (1969)PubMedCrossRefGoogle Scholar
  2. 2.
    Gross, R., Hellriegel, K.P., Heller, A.: Zur Definition der “Präleukamie” und zur Differential diagnose früher leukämischer Veränderungen. Dtsch. Med. Wochenschr. 98, 895 (1973)PubMedCrossRefGoogle Scholar
  3. 3.
    Heimpel, H.: Präleukämie. Wien. Klin. Wochenschr. 85, 378 (1973)PubMedGoogle Scholar
  4. 4.
    Hennekeuser, H.H., Möbius, W.: Untersuchungen zur Bedeutung des Peroxydase-Nach- weises bei akuter myeloischer Leukämie. Blut 29, 317 (1974)CrossRefGoogle Scholar
  5. 5.
    Linman, J.W., Bagby, G.C. Jr.: The Preleukemic Syndrome: Clinical and Laboratory Features, Natural Course, and Management. Blood Cells 2, 11 (1976)Google Scholar
  6. 6.
    Schaefer, H.E., Fischer, R.: Der Peroxydasenachweis an Ausstrichpräparaten sowie an Gewebsschnitten nach Entkalkung und Paraffineinbettung. Klin. Wochenschr. 46, 1228 (1968)CrossRefGoogle Scholar
  7. 7.
    Simamine, T.: Pathology of preleukemic state and atypical leukemia. Rinsho Ketsueki 13, 323 (1972)Google Scholar
  8. 8.
    Takahashi, I., Nakanishi, T., Sakato, J., Mokochi, H., Kitajima, K., Hiraki, K.: Preleukemia: Hematological Disorders Prior to Onset of Leukemia. Acta Med. Okayama 29, 437 (1975)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1979

Authors and Affiliations

  • I. Fohlmeister
  • H. E. Schaefer
  • K.-P. Hellriegel
  • R. Fischer

There are no affiliations available

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