A Prospective Study of Patients with Preleukemia
The natural course of disease was followed in 33 patients with so-called preleukemia by a prospective multicentric protocol. Patients with the following criteria were included: Anemia with granulocytopenia and/or thrombocytopenia, normal or increased cellularity of the bone marrow and exclusion of a known diagnosis of underlying diasease. Follow-up after assumption of “preleukemia” was 3 years or more. Median survival was 26 months after diagnosis of preleukemia and 36 months after the first unequivocal symptoms of the blood dyscrasia. 40% of the patients developed leukemia within 2 years. The most important parameters suggesting subsequent transition to overt leukemia were chromosomal abberations and an increased blast count of the bone marrow.
KeywordsAcute Myeloid Leukemia Chronic Myeloid Leukemia Aplastic Anemia Acute Leukemia Blood Dyscrasia
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