Preleukemia pp 124-127 | Cite as

A Prospective Study of Patients with Preleukemia

  • H. Heimpel
Conference paper


The natural course of disease was followed in 33 patients with so-called preleukemia by a prospective multicentric protocol. Patients with the following criteria were included: Anemia with granulocytopenia and/or thrombocytopenia, normal or increased cellularity of the bone marrow and exclusion of a known diagnosis of underlying diasease. Follow-up after assumption of “preleukemia” was 3 years or more. Median survival was 26 months after diagnosis of preleukemia and 36 months after the first unequivocal symptoms of the blood dyscrasia. 40% of the patients developed leukemia within 2 years. The most important parameters suggesting subsequent transition to overt leukemia were chromosomal abberations and an increased blast count of the bone marrow.


Benzene Leukemia Anemia Folate Thrombocytopenia 


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  1. 1.
    Heimpel, H., Drings, P., Mitrou, P., Queißier, W.: Verlauf und prognostische Kriterien bei Patienten mit “Praleukamie”. Klin. Wochenschr. 57, 21–29 (1979)PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1979

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  • H. Heimpel

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