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Psychopharmacology: Basic Aspects

  • Chapter
Grundlagen und Methoden der Psychiatrie

Part of the book series: Psychiatrie der Gegenwart ((2019,volume 1 / 2))

Abstract

The rational use of drugs requires knowledge about their mode of action. Besides, such knowledge will often initiate research toward unraveling physiologic and pathogenetic mechanisms. When Kraepelin (1892) coined the term pharmacopsychology, he emphasized this aspect: “From the particular effect of an already well-known drug on a particular mental process, the possibility exists to better recognize the true nature of the latter.” It is interesting that Sigmund Freud (1914, 1930) has expressed similar lines of thought; in fact, he is not only the father of psychoanalysis but also one of the early prophets of modern psychopharmacology. However, it did not become possible to approach this problem in a fruitful manner until the 1950s, when the antipsychotic and antidepressant drugs were discovered. In addition, the discoveries that the clinical pictures of schizophrenia and depression can be faithfully mimicked by drugs also greatly helped to promote this research field.

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References

  • Aghajanian, G.K., Bunney, B.S.: Central dopaminergic neurons: neurophysiological identification and responses to drugs. In: Frontiers in catecholamine research. Snyder, S.H., Usdin, E. (eds.), pp. 643–648. New York: Pergamon Press 1973

    Google Scholar 

  • Aghajanian, G.K., Bunney, G.S.: Pre- and postsynaptic feedback mechanisms in central dopaminergic neurons. In: Frontiers of neurology and neuroscience research. Seeman, P., Brown, G.M. (eds.), pp. 4–11. Toronto: University of Toronto Press 1974

    Google Scholar 

  • Aghajanian, G.K., Bunney, B.S.: Dopamine autoreceptors: pharmacological characterization by microiontophoretic single cell recording studies. Naunyn Schmiedebergs Arch. Pharmacol. 297, 1–8 (1977)

    PubMed  CAS  Google Scholar 

  • Aghajanian, G.K., Foote, W.E., Sheard, M.H.: Lysergic acid diethylamide: sensitive neuronal units in the mid brain raphe. Science 161, 706–708 (1968)

    PubMed  CAS  Google Scholar 

  • Ahlenius, S., Engel, J.: Effects of small doses of haloperidol on timing behaviour (Letters to the Editor). J. Pharm. Pharmacol. 23, 301–302 (1971a)

    PubMed  CAS  Google Scholar 

  • Ahlenius, S., Engel, J.: Behavioural effects of haloperidol after tyrosine hydroxylase inhibition. Eur. J. Pharmacol. 15, 187–192 (1971b)

    PubMed  CAS  Google Scholar 

  • Ahlenius, S., Engel, J.: On the interaction between pimozide and a-methyl-tyrosine. J. Pharm. Pharmacol. 25, 172–174 (1973)

    PubMed  CAS  Google Scholar 

  • Ahlenius, S., Engel, J.: Antagonism by haloperidol of the L-dopa-induced disruption of a successive discrimination in the rat. J. Neural Transm. 36, 43–49 (1975)

    PubMed  CAS  Google Scholar 

  • Ahlenius, S., Engel, J.: Normalization by antipsychotic drugs of biochemically induced behaviour in rats. Psychopharmacology 49, 119–123 (1976)

    PubMed  Google Scholar 

  • Ahlenius, S., Engel, J.: Potentiation by a-methyltyrosine of the suppression of food-reinforced leverpressing behaviour induced by antipsychotic drugs. Acta Pharmacol. Toxicol. (Kbh.) 40, 115–125 (1977)

    CAS  Google Scholar 

  • Ahlenius, S., Brown, R., Engel, J., Lundborg, P.: Learning deficits in 4 weeks old offspring of the nursing mothers treated with the neuroleptic drug penfluridol. Naunyn Schmiedebergs Arch. Pharmacol. 279, 31–37 (1973a)

    PubMed  CAS  Google Scholar 

  • Ahlenius, S., Carlsson, A., Engel, J., Svensson, T., Sodersten, P.: Antagonism by a-methyltyrosine of the ethanol-induced stimulation and euphoria in man. Clin. Pharmacol. Ther. 14, 586–591 (1973b)

    PubMed  CAS  Google Scholar 

  • Ahlenius, S., Carlsson, A., Engel, J.: Antagonism by baclophen of the β-amphetamine-induced disruption of a successive discrimination in the rat. J. Neural Transm. 36, 327–333 (1975)

    PubMed  CAS  Google Scholar 

  • Almgren, O., Carlsson, A., Engel, J. (eds.): Chemical tools in catecholamine research. II. p. 249–304.

    Google Scholar 

  • Amsterdam: North-Holland 1975 Andén, N.-E.: Monoamines and synaptic transmission. In: Monoamines, noyaux gris centraux et syndrome de Parkinson, de Ajuriaguerra, J., Gauthier, G. (eds.), pp. 61–72. Geneva: George 1971

    Google Scholar 

  • Andén, N.-E.: Dopamine turnover in the corpus striatum and the limbic system after treatment with neuroleptic and anti-acetylcholine drugs. J. Pharm. Pharmacol. 24, 905–906 (1972)

    PubMed  Google Scholar 

  • Andén, N.-E.: Catecholamine receptor mechanisms in vertebrates. In: Frontiers in catecholamine research. Snyder, S.H., Usdin, E. (eds.), pp. 661–665. New York: Pergamon Press 1973

    Google Scholar 

  • Andén, N.-E.: The interaction of neuroleptic drugs with striatal and limbic dopaminergic mechanisms. In: Antipsychotic drugs, pharmacodynamics and pharmacokinetics. Sedvall, G., Uvnás, B., Zotterman, Y. (eds.), pp. 217–225. New York: Pergamon Press 1976

    Google Scholar 

  • Andén, N.-E., Stock, G.: Effect of clozapine on the turnover of dopamine in the corpus striatum and in the limbic system. J. Pharm. Pharmacol. 25, 346–348 (1973)

    PubMed  Google Scholar 

  • Andén, N.-E., Roos, B.-E., Werdinius, B.: Effects of chlorpromazine, haloperidol and reserpine on the levels of phenolic acids in rabbit corpus striatum. Life Sci. 3, 149–158 (1964)

    Google Scholar 

  • Andén, N.-E., Dahlstrom, A., Fuxe, K., Larsson, K.: Functional role of the nigro-striatal dopamine neurons. Acta Pharmacol. Toxicol. (Kbh.) 24, 263–274 (1966)

    Google Scholar 

  • Andén, N.-E., Carlsson, A., Hággendal, J.: Adrenergic mechanisms. Annu. Rev. Pharmacol. 9, 119–134 (1969)

    PubMed  Google Scholar 

  • Andén, N.-E., Butcher, S.G., Corrodi, H., Fuxe, K., Ungerstedt, U.: Receptor activity and turnover of dopamine and noradrenaline after neuroleptics. Eur. J. Pharmacol. 11, 303–314 (1970)

    PubMed  Google Scholar 

  • Andén, N.-E., Corrodi, H., Fuxe, K.: Hallucinogenic drugs of the indolealkylamine type and central monoamine neurons. J. Pharmacol. Exp. Ther. 179, 236–249 (1971)

    PubMed  Google Scholar 

  • Andén, N.-E., Corrodi, H., Fuxe, K.: Effect of neuroleptic drugs on central catecholamine turnover assessed using tyrosine- and dopamine-/4–hydroxylase inhibitors. J. Pharm. Pharmacol. 24, 177–182 (1972 a)

    Google Scholar 

  • Andén, N.-E., Corrodi, H., Fuxe, K.: The effect of psychotomimetic glycolate esters on central monoamine neurons. Eur. J. Pharmacol. 17, 97–102 (1972 b)

    Google Scholar 

  • Andén, N.-E., Strómbom, U., Svensson, T.H.: Dopamine and noradrenaline receptor stimulation: Reversal of reserpine-induced suppression of motor activity. Psychopharmacologia 29, 289–298 (1973)

    PubMed  Google Scholar 

  • Axelrod, J., Whitby, L.G., Hertting, G.: Effect of psychotropic drugs on the uptake of 4–norepinephrine by tissues. Science 133, 383–384 (1961)

    PubMed  CAS  Google Scholar 

  • Axelsson, T.: On the serum concentrations and antipsychotic effects of thioridazine, thioridazine side-chain sulfoxide and thioridazine side-chain sulfone in chronic psychotic patients. Curr. Ther. Res. 21, 587–605 (1977)

    Google Scholar 

  • Bartholini, G.: Differential effect of neuroleptic drugs on dopamine turnover in the extrapyramidal and limbic system. J. Pharm. Pharmacol. 28, 429–433 (1975)

    Google Scholar 

  • Bartholini, G., Stadler, H.: Cholinergic and GABA-ergic influence on the dopamine release in extrapyramidal centers. In: Chemical tools in catecholamine research. II. Almgren, O., Carlsson, A., Engel, J. (eds.), pp. 235–239. Amsterdam: North-Holland 1975

    Google Scholar 

  • Bartholini, G., Stadler, H., Lloyd, K.: Cholinergic-dopaminergic interregulations within the extrapyramidal system. In: Cholinergic mechanisms. Waser, P.G. (ed.), pp. 411–418. New York: Raven Press 1975

    Google Scholar 

  • Bartholini, G., Stadler, H., Gadea-Ciria, M., Lloyd, K.G.: The use of the push-pull cannula to estimate the dynamics of acetylcholine and catecholamines within various brain areas. Neuropharmacology 15, 515–519 (1976 a)

    Google Scholar 

  • Bartholini, G., Stadler, H., Gadea-Ciria, M., Lloyd, K.G.: The effect of antipsychotic drugs on the release of neurotransmitters in various brain areas. In: Antipsychotic drugs, pharmacodynamics and pharmacokinetics. Sedvall, G., Uvnás, B., Zotterman, Y. (eds.), pp. 105–116. New York: Pergamon Press 1976b

    Google Scholar 

  • Berger, P.A., Glen, R.E., Barchas, J.D.: Neuroregulators and schizophrenia. In: Psychopharmacolo- gy: A generation of progress. Lipton, M.A., DiMascio, A., Killam, K.F. (eds.), pp. 1071–1082. New York: Raven Press 1978

    Google Scholar 

  • Berggren, U., Tallstedt, L., Ahlenius, S., Engel, J.: The effect of lithium on amphetamine-induced locomotor stimulation. Psychopharmacology 59, 41–45 (1978)

    PubMed  CAS  Google Scholar 

  • Bertilsson, L., Ásberg, M., Thorén, P.: Differential effect of chlorimipramine and nortriptyline on metabolites of serotonin and noradrenaline in the cerebrospinal fluid of depressed patients. Eur. J. Clin. Pharmacol. 7, 365–368 (1974)

    PubMed  CAS  Google Scholar 

  • Biswas, B., Carlsson, A.: The effect of intracerebroventricularly administered GABA on brain monoamine metabolism. Naunyn Schmiedebergs Arch. Pharmacol. 299, 41–46 (1977a)

    PubMed  CAS  Google Scholar 

  • Biswas, B., Carlsson, A.: The effect of intraperitoneal4 administered GABA on brain monoamine metabolism. Naunyn Schmiedebergs Arch. Pharmacol. 299, 47–51 (1977 b)

    Google Scholar 

  • Biswas, B., Carlsson, A.: Effect of intraperitoneally administered GABA in the locomotor activity of mice. Psychopharmacology 59, 91–94 (1978 a)

    Google Scholar 

  • Biswas, B., Carlsson, A.: On the mode of action of diazepam on brain catecholamine metabolism. Naunyn Schmiedebergs Arch. Pharmacol. 303, 73–78 (1978 b)

    Google Scholar 

  • Bjorklund, A., Lindvall, O.: Dopamine in dendrites of substantia nigra neurons: suggestions for a role in dendritic terminals. Brain Res. 83, 531–537 (1975)

    PubMed  CAS  Google Scholar 

  • Bosworth, D.M.: Iproniazid: A brief review of its introduction and clinial use. Ann. N.Y. Acad. Sci. 80, 809–820 (1959)

    PubMed  CAS  Google Scholar 

  • Bowers, M.B., Jr., Rozitis, A.: Regional differences in homovanillic acid concentration after acute and chronic administration of antipsychotic drugs. J. Pharm. Pharmacol. 26, 743–745

    Google Scholar 

  • Bunney, B.S., Aghajanian, G.K.: β-Amphetamine-induced inhibition of central dopaminergic neurons: mediation by a striato-nigral feedback pathway. Science 192, 391–393 (1976)

    PubMed  CAS  Google Scholar 

  • Bunney, B.S., Walters, J.R., Roth, R.H., Aghajanian, G.K.: Dopaminergic neurons: effects of antipsychotic drugs and amphetamine on single cell activity. J. Pharmacol. Exp. Ther. 185, 560–571 (1973)

    PubMed  CAS  Google Scholar 

  • Bürki, H.R., Ruch, W., Asper, H.: Effects of clozapine, thioridazine, perlapine and haloperidol on the metabolism of the biogenic amines in the brain of the rat. Psychopharmacology 41, 27–33 (1975)

    Google Scholar 

  • Carlsson, A.: Drugs which block the storage of 5–hydroxytryptamine and related amines. In: Handbuch der experimentellen Pharmakologie. Erganzungswerk, Bd. XIX. Erspamer, V. (Hrsg.), S. 529–592. Berlin: Springer 1965

    Google Scholar 

  • Carlsson, A.: Amphetamine and brain catecholamines. In: Proceedings of the Mario Negri Institute for Pharmacological Research. Costa, E., Garattini, S. (eds.), pp. 289–300. New York: Raven Press 1970

    Google Scholar 

  • Carlsson, A.: Biochemical and pharmacological aspects of parkinsonism. Proceedings of the Twentieth Congress of Scandinavian Neurologists, Oslo, 1972. Acta Neurol. Scand. 48, Suppl. 51, 11–42 (1972)

    CAS  Google Scholar 

  • Carlsson, A.: Antipsychotic drugs and catecholamine synapses. J. Psychiatr. Res. 11, 57–64 (1974)

    PubMed  CAS  Google Scholar 

  • Carlsson, A.: Dopaminergic autoreceptors. In: Chemical tools in catecholamine research. II. Almgren, O., Carlsson, A., Engel, J. (eds.), pp. 219–225. Amsterdam: North-Holland 1975a

    Google Scholar 

  • Cailsson, A.: Monoamine-depleting drugs. Pharmacol. Ther. [B] 1 (3), 393–400 (1975b)

    Google Scholar 

  • Carlsson, A.: Drugs acting through dopamine release. Pharmacol. Ther. [B] 1 (3), 401–405 (1975c)

    CAS  Google Scholar 

  • Carlsson, A.: The contribution of drug research to investigating the nature of endogenous depression. Pharmakopsychiatrie 1, 2–10 (1976)

    Google Scholar 

  • Carlsson, A.: Does dopamine play a role in schizophrenia? Psychol. Med. 7, 583–597 (1977a)

    PubMed  CAS  Google Scholar 

  • Carlsson, A.: The influence of antidepressants on central monoaminergic systems. In: Neurotrans-mission and disturbed behaviour, van Praag, H.M. (ed.), pp. 19–33. Amsterdam: Erven Gohn B.V. 1977b

    Google Scholar 

  • Carlsson, A., Lindqvist, M.: Effect of chlorpromazine or haloperidol on formation of 3–methoxytyra-mine and normetanephrine in mouse brain. Acta Pharmacol. Toxicol. (Kbh.) 20, 140–144 (1963)

    CAS  Google Scholar 

  • Carlsson, A., Lindqvist, M.: Effect of ethanol on the hydroxylation of tyrosine and tryptophan in rat brain in vivo. J. Pharm. Pharmacol. 25, 437–440 (1973)

    PubMed  CAS  Google Scholar 

  • Carlsson, A., Lindqvist, M.: Effect of reserpine on monoamine synthesis and on apparent dopaminergic receptor sensitivity in rat brain. In: Neuropharmacology and behaviour. Haber, B., Aprison, M.H. (eds.), pp. 89–102. New York: Plenum 1978a

    Google Scholar 

  • Carlsson, A., Lindqvist, M.: Dependence of 5–HT and catecholamine synthesis on concentrations of precursor amino-acids in rat brain. Naunyn Schmiedebergs Arch. Pharmacol. 303, 157–164 (1978 b)

    Google Scholar 

  • Carlsson, A., Lindqvist, M.: Effects of antidepressant agents on the synthesis of brain monoamines. J. Neural Transm. 43, 73–91 (1978c)

    PubMed  CAS  Google Scholar 

  • Carlsson, A., Corrodi, H., Fuxe, K., Hokfelt, T.: Effect of antidepressant drugs on the depletion of intraneuronal brain 5–hydroxtryptamine stores caused by 4–methyl-a-ethyl-meta-tyramine. Eur. J. Pharmacol. 5, 357–366 (1969a)

    PubMed  CAS  Google Scholar 

  • Carlsson, A., Corrodi, H., Fuxe, K., Hokfelt, T.: Effects of some antidepressant drugs on the depletion of intraneuronal brain catecholamine stores caused by 4,a-dimethyl-meta-tyramine. Eur. J. Pharmacol. 5, 367–373 (1969b)

    PubMed  CAS  Google Scholar 

  • Carlsson, A., Davis, J.N., Kehr, W., Lindqvist, M., Atack, C.V.: Simultaneous measurement of tyrosine and tryptophan hydroxylase activities in brain in vivo using an inhibitor of the aromatic amino acid decarboxylase. Naunyn Schmiedebergs Arch. Pharmacol. 275, 153–168 (1972 a)

    Google Scholar 

  • Carlsson, A., Engel, J., Svensson, T.H.: Inhibition of ethanol-induced excitation in mice and rats by a-methyl-p-tyrosine. Psychopharmacology 26, 307–312 (1972 b)

    Google Scholar 

  • Carlsson, A., Engel, J., Strombom, U., Svensson, T.H., Waldeck, B.: Suppression by dopamine-agonists of the ethanol-induced stimulation of locomotor activity and brain dopamine synthesis. Naunyn Schmiedebergs Arch. Pharmacol. 283, 117–128 (1974)

    PubMed  CAS  Google Scholar 

  • Chesher, G.B.: Facilitation of avoidance acquisition in the rat by ethanol and its abolition by a-methyl-p-tyrosine. Psychopharmacology 39, 87–95 (1974)

    CAS  Google Scholar 

  • Christiansen, J., Squires, R.F.: Antagonistic effects of apomorphine and haloperidol on rat striatal synaptosomal tyrosine hydroxylase. J. Pharm. Pharmacol. 26, 367–368 (1974)

    PubMed  CAS  Google Scholar 

  • Clement-Cormier, Y.C., Kebabian, J.W., Petzold, G.L., Greengard, P.: Dopamine-sensitive adenylate cyclase in mammalian brain: a possible site of action of antipsychotic drugs. Proc. Natl. Acad. Sci. U.S.A. 71, 1113–1117 (1974)

    PubMed  CAS  Google Scholar 

  • Corrodi, H., Fuxe, K.: Decreased turnover in central 5–HT nerve terminals induced by antidepressant drugs of the imipramine type. Eur. J. Pharmacol. 7, 56–59 (1969)

    PubMed  CAS  Google Scholar 

  • Corrodi, H., Hanson, L.C.F.: Central effects of an inhibitor of tyrosine hydroxylation. Psychopharmacology 10, 116–125 (1966)

    CAS  Google Scholar 

  • Costa, E., Gessa, G.L., Sandler, M. (eds.): Serotonin - New Vistas. Biochemistry and behavioral and clinical studies. In: Advances in biochemical psychopharmacology. Vol. XI, pp. 1–168. New York: Raven Press 1974a

    Google Scholar 

  • Costa, E., Gessa, G.L., Sandler, M. (eds.): Serotonin - New Vistas. Biochemistry and behavioral and clinical studies. In: Advances in biochemical psychopharmacology. Vol. XI, pp. 169–216. New York: Raven Press 1974b

    Google Scholar 

  • Costa, E., Gessa, G.L., Sandler, M. (eds.): Serotonin — New Vistas. Biochemistry and behavioral and clinical studies. In: Advances in biochemical psychopharmacology. Vol. XI, pp. 217–264. New York: Raven Press 1974c

    Google Scholar 

  • Costa, E., Guidotti, A., Mao, C.C.: A GABA hypothesis for the action of benzodiazepines. In: GABA in nervous system function. Kroc Foundation Series, Vol. V. Roberts, E., Chase, T.N., Torver, D.B. (eds.), pp. 413426. New York: Raven Press 1976

    Google Scholar 

  • Cott, J., Carlsson, A., Engel, J., Lindqvist, M.: Suppression of ethanol-induced locomotor stimulation by GABA-like drugs. Naunyn Schmiedebergs Arch. Pharmacol. 295, 203–209 (1976)

    PubMed  CAS  Google Scholar 

  • Creese, I., Burt, D.R., Snyder, S.H.: Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science 192, 481–483 (1976)

    PubMed  CAS  Google Scholar 

  • Da Prada, M., Pletscher, A.: Acceleration of cerebral dopamine turn-over by chlorpromazine. Experientia 22, 465–466 (1966)

    PubMed  Google Scholar 

  • Davis, K.L., Hollister, L.E., Berger, P.A.: Baclofen in schizophrenia. Lancet 19761, 1245

    Google Scholar 

  • Delay, J., Deniker, O.: Charactéristiques psychophysiologiques des médicaments neuroleptiques. In: Psychotropic drugs. Garattini, S., Ghetti, V. (eds.), pp. 485–501. Amsterdam: Elsevier 1957

    Google Scholar 

  • Dengler, H.J., Spiegel, H.E., Titus, E.O.: Uptake of tritium-labelled norepinephrine in brain and other tissues of cat in vitro. Science 133, 1072–1073 (1961)

    PubMed  CAS  Google Scholar 

  • Engel, J., Carlsson, A.: Catecholamines and behaviour. Curr. Dev. Psychopharmacol. 4, 1–32 (1976)

    Google Scholar 

  • Engel, J., Liljequist, S.: Behavioural effects of 4–receptor blocking agents in experimental animals. In: Neuro-psychiatric effects of adrenergic beta-receptor blocking agents. Clin. Pharmacol. 12, 45–52 (1976a)

    Google Scholar 

  • Engel, J., Liljequist, S.: The effect of long-term ethanol treatment on the sensitivity of the dopamine receptors in the nucleus accumbens. Psychopharmacology 49, 253–257 (1976 b)

    Google Scholar 

  • Engel, J., Lundborg, P.: Regional changes in monoamine levels and in the rate of tyrosine and tryptophan hydroxylation in 4 week old offspring of nursing mothers treated with the neuroleptic drug penfluridol. Naunyn Schmiedebergs Arch. Pharmacol. 282, 327–334 (1974)

    PubMed  CAS  Google Scholar 

  • Engel, J., Liljequist, S., Johannesen, K.: Behavioural effects of long-term treatments with antipsychotic drugs. In: Antipsychotic drugs, pharmacodynamics and pharmacokinetics. Sedvall, G., Uvnâs, B., Zotterman, Y. (eds.), pp. 63–71. Oxford: Pergamon Press 1976

    Google Scholar 

  • Farnebo, L.-O., Hamberger, B.: Drug-induced changes in the release of [3H]-monoamines from field stimulated rat brain slices. Acta Physiol. Scand. 84, Suppl. 371, 35–44 (1971)

    CAS  Google Scholar 

  • Felger, H.L.: Depressed hospitalized psychiatric patients treated with chlorprothixene concentrate. J. N. Drugs 5, 240–248 (1965)

    CAS  Google Scholar 

  • Forsman, A.: Individual differences in clinical response to an antipsychotic drug. Theses, pp. 1–33. University of Gôteborg 1977

    Google Scholar 

  • Forsman, A., Ôhman, R.: Studies on plasma protein binding of haloperidol. Curr. Ther. Res. 21, 245–255 (1977)

    PubMed  CAS  Google Scholar 

  • Forsman, A., Mârtensson, E., Nyberg, G., Ôhman, R.: A gas chromatographic method for determining haloperidol. Naunyn Schmiedebergs Arch. Pharmacol. 286, 113–124 (1974)

    PubMed  CAS  Google Scholar 

  • Frederiksen, P.K.: Baclofen in the treatment of schizophrenia. Lancet 19751, no. 7908, 702–703

    Google Scholar 

  • Freud, S.: On narcissism - An introduction. (Trans. 1962 J. Strachey), p. 73. London: Hogarth Press 1914

    Google Scholar 

  • Freud, S.: Letter to Marie Bonaparte, 15 January 1930. Cited by Jones, E. (1957). In: The life and work of Sigmund Freud. Vol. III, p. 449. New York: Basic Books 1930

    Google Scholar 

  • Fuxe, K., Sjöqvist, F.: Hypothermic effect of apomorphine in the mouse. J. Pharm. Pharmacol. 24, 702–705 (1972)

    PubMed  CAS  Google Scholar 

  • Garcia-Sevilla, J.A., Magnusson, T., Carlsson, A.: Effect of intracerebroventricularly administered somatostatin on brain monoamine turnover. Brain Res. 155, 159–164 (1978)

    PubMed  CAS  Google Scholar 

  • Gershon, S., Heikimian, L.J., Floyd, A., Jr., Hollister, L.E.: Methyl-/?-tyrosine (AMT) in schizophrenia. Psychopharmacology 11, 189–194 (1967)

    CAS  Google Scholar 

  • Glowinski, J., Axelrod, J.: Effects of drugs on the uptake, release and metabolism of norepinephrine in the rat brain. J. Pharmacol. Exp. Ther. 149, 43–49 (1965)

    PubMed  CAS  Google Scholar 

  • Goldstein, M., Anagnoste, B., Shirron, C.: The effect of trivastal, haloperidol and dibutyryl cyclic AMP on 14C dopamine synthesis in rat striatum. J. Pharm. Pharmacol. 25, 348–351 (1973)

    PubMed  CAS  Google Scholar 

  • Goodman, L.S., Gilman, A. (eds.): The pharmacological basis of therapeutics, 5th ed. pp. 148–149. New York: Macmillan 1975

    Google Scholar 

  • Goodwin, F.K., Murphy, D.L., Brodie, H.K.H., Bunney, W.E.: Levodopa: alterations in behaviour. Clin. Pharmacol. Ther. 12, 383–396 (1971)

    PubMed  CAS  Google Scholar 

  • Greengard, P.: Presynaptic and postsynaptic roles of cyclic AMP and protein phosphorylation at catecholaminergic synapses. In: Chemical tools in catecholamine research. Almgren, O., Carlsson, A., Engel, J. (eds.), Vol. II, pp. 249–256. Amsterdam: North-Holland 1975

    Google Scholar 

  • Groves, P.M., Wilson, C.J., Young, S.J., Rebec, G.V.: Self-inhibition by dopaminergic neurons. Science 190, 522–529 (1975)

    PubMed  CAS  Google Scholar 

  • Guidotti, A.: Synaptic mechanisms in the action of benzodiazepines. In: Psychopharmacology: A generation of progress. Lipton, M.A., DiMascio, A., Killam, K.F. (eds.), pp. 1349–1357. New York: Raven Press 1978

    Google Scholar 

  • Henning, M.: Central sympathetic transmitters and hypertension. Clin. Sci. Mol. Med. 48, 195–203 (1975)

    Google Scholar 

  • Hertting, G., Axelrod, J., Kopin, J.J., Whitby, L.G.: Lack of uptake of catecholamines after chronic denervation of sympathetic nerves. Nature 189, 66 (1961)

    PubMed  CAS  Google Scholar 

  • Hökfelt, T., Johansson, O., Fuxe, K., Löfström, A., Goldstein, M., Park, D., Ebstein, R., Fraser, H., Jeffcoate, S., Effendie, S., Luft, R., Arimura, A.: Mapping and relationship of hypothalamic neurotransmitters and hypothalamic hormones. In: Proceedings of the Sixth International Congress of Pharmacology. Tuomisto, J., Paasonen, M.K. (eds.), Vol. Ill, p. 93–110. Helsinki, Finland: 1975

    Google Scholar 

  • Huxtable, R., Barbeau, A. (eds.): Taurine. New York: Raven Press 1976

    Google Scholar 

  • Hyttel, J.: Effect of neuroleptics on the disappearance rate of 14C labelled catecholamines formed from 14C tyrosine in mouse brain. J. Pharm. Pharmacol. 26, 588–596 (1974)

    PubMed  CAS  Google Scholar 

  • Iversen, L.L., Otsuka, M.: Symposium on novel transmitter substances. In: Proceedings of the Sixth International Congress of Pharmacology. Tuomisto, J., Paasonen, M.K. ( eds. ), Vol. III, pp. 35–102.

    Google Scholar 

  • Helsinki, Finland: 1975 Iversen, L.L., Rogawski, M.A., Miller, R.J.: Comparison of the effects of neuroleptic drugs on pre- and postsynaptic dopaminergic mechanisms in the rat striatum. Mol. Pharmacol. 12, 251–262 (1976)

    Google Scholar 

  • Jackson, D.M., Andén, N.-E., Dahlström, A.: A functional effect of dopamine in the nucleus accumbens and in some other dopamine-rich parts of the rat brain. Psychopharmacology 45, 139–149 (1975)

    CAS  Google Scholar 

  • Jarvik, M.E.: Drugs used in the treatment of psychiatric disorders. In: The pharmacological basis of therapeutics, 3rd ed. Goodman, L.S., Gilman, A. (eds.), pp. 159–214. New York: Macmillan 1965

    Google Scholar 

  • Javoy, F., Agid, Y., Bouvet, D., Glowinski, J.: Changes in neostriatal dopamine metabolism after carbachol or atropine microinjections into the substantia nigra. Brain Res. 68, 253–260 (1974)

    PubMed  CAS  Google Scholar 

  • Jonason, J.: Metabolism of dopamine and noradrenaline in normal atrophied and postganglionically sympathectomized rat salivary glands in vitro. Acta Physiol. Scand. 76, 299–311 (1969)

    PubMed  CAS  Google Scholar 

  • Jönsson, L.-E., Günne, L.-M., Änggard, E.: Effects of a-methyltyrosine in amphetamine-dependent subjects. Pharmacol. Clin. 2, 27–29 (1969)

    Google Scholar 

  • Kamberi, I.A., Thorn, N.A.: Symposium on interactions of neurotransmitters and the hypothalamic releasing hormones. In: Proceedings of the Sixth International Congress of Pharmacology. Tuomisto, J., Paasonen, M.K. (eds.), Vol. Ill, pp. 93–167. Helsinki, Finland: 1975

    Google Scholar 

  • Kebabian, J.W., Greengard, P.: Dopamine-sensitive adenyl cyclase: possible role in synaptic transmission. Science 174, 1346–1349 (1971)

    PubMed  CAS  Google Scholar 

  • Kehr, W., Speckenbach, W.: Effect of lisuride and LSD on monoamine synthesis after axotomy or reserpine treatment in rat brain. Naunyn Schmiedebergs Arch. Pharmacol. 301, 163–169 (1978)

    PubMed  CAS  Google Scholar 

  • Kehr, W., Carlsson, A., Lindqvist, M., Magnusson, T., Atack, C.: Evidence for a receptor-mediated feedback control of striatal tyrosine hydroxylase activity. J. Pharm. Pharmacol. 24, 744–747 (1972)

    PubMed  CAS  Google Scholar 

  • Kehr, W., Carlsson, A., Lindqvist, M.: Catecholamine synthesis in rat brain after axotomy: interaction between apomorphine and haloperidol. Naunyn Schmiedebergs Arch. Pharmacol. 297, 111–117 (1977)

    PubMed  CAS  Google Scholar 

  • Kilian, M., Frey, H.H.: Central monoamines and convulsive thresholds in mice and rats. Neuropharmacology 12, 681–692 (1973)

    PubMed  CAS  Google Scholar 

  • Klein, D.F., Davis, J.M.: Diagnosis and drug treatment of psychiatric disorders. Baltimore: Williams and Wilkins 1969

    Google Scholar 

  • Knapp, S., Mandell, A.J.: Effects of lithium chloride on parameters of biosynthetic capacity for 5–hydroxytryptamine in rat brain. J. Pharmacol. Exp. Ther. 193, 812–823 (1975)

    PubMed  CAS  Google Scholar 

  • Kraepelin, E.: Über die Beeinflussung einfacher psychischer Vorgänge durch einige Arzneimittel, S. 227. Jena: Gustav Fischer 1892

    Google Scholar 

  • Kuhn, R.: The treatment of depressive states with G 22355 (imipramine hydrochloride). Am. J. Psychiatry 115, 459 (1958)

    PubMed  CAS  Google Scholar 

  • Ladinsky, H., Consolo, S., Bianchi, S., Samanin, R., Ghezzi, D.: Cholinergic-dopaminergic interaction in the striatum: the effect of 6–hydroxydopamine or pimozide treatment on the increased striatal acetylcholine levels induced by apomorphine, piribedil and 4–amphetamine. Brain Res. 84, 221–226 (1975)

    PubMed  CAS  Google Scholar 

  • Lebensohn, Z.M., Jenkins, R.B.: Improvement of parkinsonism in depressed patients treated with ECT. Am. J. Psychiatry 132, 283–285 (1975)

    PubMed  CAS  Google Scholar 

  • Lehmann, J.: Tryptophan malabsorption in levodopa-treated parkinsonian patients. Acta Med. Scand. 194, 181–189 (1973)

    CAS  Google Scholar 

  • Loomer, H.P., Saunders, J.C., Kline, N.S.: A clinical and pharmacodynamic evaluation of iproniazid as a psychic energizer. Am. Psychiatr. Assoc. Psychiatric Res. Rep. 8, 129 (1957)

    CAS  Google Scholar 

  • Lundborg, P., Engel, J.: Learning deficits and selective biochemical brain changes in 4–week-old offspring of nursing rat mothers treated with neuroleptics. In: Antipsychotic drugs, pharmacodynamics and pharmacokinetics. Sedvall, G., Uvnäs, B., Zotterman, Y. (eds.), pp. 261–269. Oxford: Pergamon Press 1976

    Google Scholar 

  • MacLeod, R.M., Lehmeyer, J.E.: Studies on the mechanism of the dopamine-mediated inhibition of prolactin secretion. Endocrinology 94, 1077–1085 (1974)

    PubMed  CAS  Google Scholar 

  • Magnusson, T., Carlsson, A., Fisher, G.H., Chang, D., Folkers, K.: Effect of synthetic substance P on monoaminergic mechanisms in brain. J. Neural Transm. 38, 89–93 (1976)

    PubMed  CAS  Google Scholar 

  • Marshall, E., Stirling, G.S., Tait, A.C., Todrick, A.: The effect of iproniazid and imipramine on the blood platelet serotonin level in man. Br. J. Pharmacol. 15, 3541 (1960)

    Google Scholar 

  • McCann, S.M., Kaira, P.S., Donoso, A.P., Bishop, W., Schneider, H.P.G., Fawcett, C.P., Krulich, L.: The role of monoamines in the control of gonadotropin and prolactin secretion. In: Median eminence: Structure and function. Knugge, K.M., Scott, D.F., Weendl, A. (eds.), pp. 224–235. Basel: Karger 1972

    Google Scholar 

  • McGeer, P.L., Grewaal, D.S., McGeer, E.G.: Influence of non-cholinergic drugs on rat striatal acetylcholine levels. Brain Res. 80, 211–217 (1974)

    PubMed  CAS  Google Scholar 

  • Meek, J., Werdinius, B.: Hydroxytryptamine turnover decreased by the antidepressant drug chlorimipramine. Letter to the Editor. J. Pharm. Pharmacol. 22, 141–143 (1970)

    PubMed  CAS  Google Scholar 

  • Meites, J., Lu, K.-H., Wuttke, W., Welsch, C.W., Nagasawa, H., Quadri, S.K.: Recent studies on functions and control of prolactin secretion in rats. Recent Prog. Horm. Res. 28, 471–526 (1972)

    CAS  Google Scholar 

  • Meitzer, H.Y., Fang, V.S.: Serum prolactin levels in schizophrenia: effect of antipsychotic drugs. A preliminary report. In: Hormones, behaviour and psychopathology. Sachar, E.J. (ed.). New York: Raven Press 1976

    Google Scholar 

  • Meitzer, H.Y., Stahl, M.: The dopamine hypothesis of schizophrenia: a review. Schizophrenia Bull. 2, 19–76 (1976)

    Google Scholar 

  • Miller, R.J., Horn, A.S., Iversen, L.L.: The action of neuroleptic drugs on dopaminestimulated adenosine cyclic 3’,5’monophosphate production in rat neostriatum and limbic forebrain. Mol. Pharmacol. 10, 759–766 (1974)

    CAS  Google Scholar 

  • Miller, R.J., Horn, A.S., Iversen, L.L.: Effect of butaclamol on dopamine-sensitive adenylate cyclase in rat striatum. J. Pharm. Pharmacol. 27, 212–213 (1975)

    PubMed  CAS  Google Scholar 

  • Modigh, K.: Functional aspects of 5–hydroxytryptamine turnover in the central nervous system. Acta Physiol. Scand., Suppl. 403, 5–56 (1974)

    Google Scholar 

  • Modigh, K.: Electro-convulsive shock and postsynaptic catecholamine effects: Increased psychomotor stimulant action of apomorphine and clonidine in reserpine-pretreated mice by repeated ECS. J. Neural Transm. 36, 19–32 (1975)

    PubMed  CAS  Google Scholar 

  • Modigh, K., Svensson, T.H.: On the role of central nervous system catecholamines and 5–hydroxytryptamine in the nialamide-induced behavioural syndrome. Br. J. Pharmacol. 46, 32–45 (1972)

    PubMed  CAS  Google Scholar 

  • Moller-Nielsen, I., Fjalland, B., Pedersen, V., Nymark, M.: Pharmacology of neuroleptics upon repeated administration. Psychopharmacology 34, 95–104 (1974)

    CAS  Google Scholar 

  • Nyback, H.: On the relation between transmitter turnover and impulse flow in brain catecholamine neurons. In: Chemical tools in catecholamine research. II. Almgren, O., Carlsson, A., Engel, J. (eds.), pp. 127–134. Amsterdam: North Holland 1975

    Google Scholar 

  • Nyback, H., Sedvall, G.: Further studies on the accumulation and disappearance of catecholamines formed from tyrosine-14C in mouse brain. Effect of some phenothiazine analogues. Eur. J. Pharmacol. 10, 193–205 (1970)

    PubMed  CAS  Google Scholar 

  • Nyback, H.V., Walters, J.R., Aghajanian, G.K., Roth, R.H.: Tricyclic antidepressants: effects on the firing rate of brain noradrenergic neurons. Eur. J. Pharmacol. 32, 3Q2–312 (1975)

    Google Scholar 

  • Nyberg, G., Axelsson, R., Martensson, E.: On the binding of thioridazine and thioridazine metabolites to serum proteins in psychiatric patients. Eur. J. Clin. Pharmacol. (1979) (in press)

    Google Scholar 

  • Ohman, R., Larsson, M., Nilsson, I.M., Engel, J., Carlsson, A.: Neurometabolic and behavioural effects of haloperidol in relation to drug levels in serum and brain. Naunyn Schmiedebergs Arch. Pharmacol. 299, 105–114 (1977)

    CAS  Google Scholar 

  • Okada, Y.: Role of GABA in the substantia nigra. In: GABA in nervous system function. Roberts, E., Chase, T.N., Tower, D.B. (eds.), pp. 235–243. New York: Raven Press 1976

    Google Scholar 

  • O’Keefe, R., Sharman, D.F., Vogt, M.: Effect of drugs used in psychoses on cerebral dopamine metabolism. Br. J. Pharmacol. 38, 287–304 (1970)

    Google Scholar 

  • Otsuka, M., Konishi, S., Takahaski, T.: Hypothalamic substance P as a candidate for transmitter of primary afferent neurons. Fed. Proc. 34, 1922–1928 (1975)

    PubMed  CAS  Google Scholar 

  • Persson, S.-A., Johansson, H.: The effect of lysergic acid diethylamide (LSD) and 2–bromo-lysergic acid diethylamide (BOL) on the striatal DOPA accumulation: influence of central 5–hydroxytrypt- aminergic pathways. Brain Res. 142, 505–513 (1978)

    PubMed  CAS  Google Scholar 

  • Pijnenburg, A.J.J., Woodruff, G.N., van Rossum, J.M.: Ergometrine induced locomotor activity following intracerebral injection into the nucleus accumbens. Brain Res. 59, 289–302 (1973)

    PubMed  CAS  Google Scholar 

  • Powell, D., Leeman, S.E., Tregear, G.W., Niall, H.D., Potts, J.T.: Radioimmunoassay for substance P. Nature [New Biol.] 241, 252–254 (1973)

    CAS  Google Scholar 

  • van Praag, H.M.: Therapy-resistant depressions: biochemical and pharmacological considerations. Psychother. Psychosom. 23, 169–178 (1974)

    Google Scholar 

  • van Praag, H.M., van den Burg, W., Bos, E.R.H., Dols, L.C.W.: 5–Hydroxytryptophan in combination with clomipramine in “therapy-resistant” depressions. Psychopharmacology 38, 625–648 (1974)

    Google Scholar 

  • Roberts, E., Chase, T.N., Tower, D.B. (eds.): GABA in nervous system function. In: Kroc Foundation Series, vol. V. New York: Raven Press 1976

    Google Scholar 

  • Samanin, R., Bernasconi, S., Garattini, S.: The effect of nomifensine on the depletion of brain serotonin and catecholamines induced respectively by fenfluramine and 6–hydroxydopamine in rats. Eur. J. Pharmacol. 34, 377–380 (1975)

    PubMed  CAS  Google Scholar 

  • Schaar, C.J., Clemens, J. A.: The role of catecholamines in the release of anterior pituitary prolactin in vitro. Endocrinology 95, 1202–1212 (1974)

    Google Scholar 

  • Scheel-Kruger, J.: Pharmacological studies on a counterbalancing adrenergic-cholinergic system in the brain. Acta Physiol. Scand. 77, Suppl. 330, 66 (1969)

    Google Scholar 

  • Scheel-Kruger, J.: Comparative studies of various amphetamine analogues demonstrating different interactions with the metabolism of the catecholamines in the brain. Eur. J. Pharmacol. 14, 47–59 (1971)

    PubMed  CAS  Google Scholar 

  • Scheel-Krüger, J.: Some aspects of the mechanisms of action of various stimulant amphetamine analogues. Psychiatr. Neurol. Neurochir. 75, 179–192 (1972)

    PubMed  Google Scholar 

  • Schlatter, E.K.E., Lai, S.: Treatment of alcoholism with Dent’s oral apomorphine method. Q. J. Stud. Alcohol. 33, 430–436 (1972)

    PubMed  CAS  Google Scholar 

  • Sedvall, G., Nyback, G.: Neuroleptikabehandling vid schizofreni. Nord. Psyk. Tidskr. 26, 323–340 (1972)

    CAS  Google Scholar 

  • Sedvall, G., Alfredsson, G., Bjerkenstedt, L., Eneroth, P., Fyro, B., Harnryd, C., Swahn, C.-G., Wiesel, F.-A., Wode-Helgodt, B.: Selective effects of psychoactive drugs on levels of monoamine metabolites and prolactin in cerebrospinal fluid of psychiatric patients. In: Proceedings of the Sixth International Congress of Pharmacology. Tuomisto, J., Paasonen, M.K. (eds.), Vol. Ill, pp. 255–267. Helsinki, Finland: 1975

    Google Scholar 

  • Seeman, P., Lee, T.: Antipsychotic drugs: direct correlation between clinical potency and presynaptic action on dopamine neurons. Science 188, 1217–1219 (1975)

    PubMed  CAS  Google Scholar 

  • Seeman, P., Staiman, A., Lee, T., Chang-Wang, M.: The membrane actions of tranquillizers in relation to neuroleptic-induced Parkinsonism and tardive dyskinesia. In: The phenothiazines and structurally related drugs. Forrest, S., Carr, C.J., Usdin, E. (eds.), pp. 137–148. New York: Raven Press 1974

    Google Scholar 

  • Seeman, P., Lee, T., Chan-Wong, M., Wong, K.: Antipsychotic drug doses and neuroleptic dopamine receptors. Nature 261, 717–719 (1976)

    PubMed  CAS  Google Scholar 

  • Sethy, V.H., van Woert, M.H.: Modification of striatal acetylcholine concentration by dopamine receptor agonists and antagonists. Res. Commun. Chem. Pathol. Pharmacol. 8, 13–28 (1974)

    PubMed  CAS  Google Scholar 

  • Shopsin, B.S., Gershon, S., Goldstein, M., Friedman, E., Wilk, S.: Use of synthesis inhibitors in defining role for biogenic amines during imipramine treatment in depressed patients. Psycho- pharmacol. Commun. 1 (2), 239–249 (1975)

    CAS  Google Scholar 

  • Shore, P.A.: Release of serotonin and catecholamines by drugs. Pharmacol. Rev. 14, 531–550 (1962)

    PubMed  CAS  Google Scholar 

  • Sigg, E.B.: Pharmacological studies with tofranil. Can. Psychiatr. Assoc. J. 45, 75–85 (1959)

    Google Scholar 

  • Sigg, E.B., Soffer, L., Gyermek, L.: Influence of imipramine and related psychoactive agents on the effect of 5–hydroxytryptamine and catecholamines on the cat nictitating membrane. J. Pharmacol. Exp. Ther. 142, 13–20 (1963)

    PubMed  CAS  Google Scholar 

  • Simpson, G.M., Branchey, M.H., Shiwastava, R.K.: Baclofen in schizophrenia. Lancet 19761, 966–967

    Google Scholar 

  • Siwers, B.: Clinical pharmacological assessment of some antidepressant drugs. Thesis Stockholm 1976

    Google Scholar 

  • Smith, R.C., Davis, J.M.: Behavioural evidence for supersensitivity after chronic administration of haloperidol, clozapine, and thioridazine. Life Sci. 19, 725–732 (1976)

    PubMed  CAS  Google Scholar 

  • Snyder, S.H., Burt, D.R., Creese, I.: The dopamine receptor of mammalian brain: direct demonstration of binding to agonist and antagonist states. Soc. Neurosci. Symp. 1, 28–49 (1976)

    CAS  Google Scholar 

  • Squires, R.F., Braestrup, C.: Benzodiazepine receptors in rat brain. Nature 266, 732–734 (1977)

    PubMed  CAS  Google Scholar 

  • Stadler, H., Lloyd, K.B., Gadea-Ciria, M., Bartholoni, G.: Enhanced striatal acetylcholine release by chlorpromazine and its reversal by apomorphine. Brain Res. 55, 476–480 (1973)

    PubMed  CAS  Google Scholar 

  • Stawarz, R.J., Hill, H., Robinson, S.E., Settler, P., Dingell, J.V., Sulser, F.: On the significance of the increase in homovanillic acid (HVA) caused by antipsychotic drugs in corpus striatum and limbic forebrain. Psychopharmacology 43, 125–130 (1975)

    CAS  Google Scholar 

  • Stein, L.: Self stimulation of the brain and central stimulant action of amphetamine. Fed. Proc. 23, 836–850 (1964)

    PubMed  CAS  Google Scholar 

  • Stille, G., von, Lauener, H.: Zur Pharmakologie katatonigener Stoffe, I. Mitteilung: Korrelation zwischen neuroleptischer Katalepsie und Homovanillinsauregehalt im C. striatum bei Ratten. Arzneim.-Forsch. 21, 252–255 (1971)

    CAS  Google Scholar 

  • Stromberg, U., Svensson, T.H., Waldeck, B.: On the mode of action of amantadine. J. Pharm. Pharmacol. 22, 959–962 (1970)

    PubMed  CAS  Google Scholar 

  • Strombom, U.: Antagonism by haloperidol of locomotor depression induced by small doses of apomorphine. J. Neural Transm. 40, 191–194 (1977)

    PubMed  CAS  Google Scholar 

  • Svensson, T.: The effect of inhibition of catecholamine synthesis on dexamphetamine induced central stimulation. Eur. J. Pharmacol. 12, 161–166 (1970)

    PubMed  CAS  Google Scholar 

  • Svensson, T.: Functional and biochemical effects of d- and 1–amphetamine on central catecholamine neurons. Naunyn Schmiedebergs Arch. Pharmacol. 271, 170–180 (1971)

    CAS  Google Scholar 

  • Svensson, T.: Dopamine release and direct receptor activation in the central nervous system by D-145, an amantadine derivative. Eur. J. Pharmacol. 23, 232–238 (1973)

    PubMed  CAS  Google Scholar 

  • Svensson, T., Stromberg, U.: Potentiation by amantadine hydrochloride of L-DOPA-induced effects in mice. J. Pharm. Pharmacol. 22, 639–640 (1970)

    PubMed  CAS  Google Scholar 

  • Trabucchi, M., Cheney, D.L., Racagni, G., Costa, E.: In vivo inhibition of striatal acetylcholine turnover by L-dopa, apomorphine and (+)-amphetamine. Brain Res. 85, 130–134 (1975)

    PubMed  CAS  Google Scholar 

  • Ungerstedt, U.: Stereotaxic mapping of the monoamine pathway in the rat brain. Acta Physiol. Scand. 82, Suppl. 367, 1–48 (1971)

    CAS  Google Scholar 

  • Ungerstedt, U., Ljungberg, T., Hoffer, B., Siggins, G.: Dopaminergic supersensitivity in the striatum. Adv. Neurol. 9, 57–65 (1975)

    PubMed  CAS  Google Scholar 

  • Usdin, E., Snyder, S. (eds.): Frontiers in catecholamine research, pp.1–106. New York: Pergamon Press 1973 a

    Google Scholar 

  • Usdin, E., Snyder, S. (eds.): Frontiers in catecholamine research, pp. 399–626. New York: Pergamon Press 1973 b

    Google Scholar 

  • Wadstein, J., Ohlin, H., Stenberg, P.: Effects of apomorphine and apomorphine-L-dopa-carbidopa on alcohol post-intoxication symptoms. Drug Alcohol Dependence (1978) (in press)

    Google Scholar 

  • Waldeck, B.: Effect of caffeine on locomotor activity and central catecholamine mechanisms: A study with special reference to drug interaction. Acta Pharmacol. Toxicol (Kbh.) 36, Suppl. 4, 1–23 (1975)

    Google Scholar 

  • Walinder, J., Carlsson, A.: Potentiation of neuroleptics by catecholamine inhibitors. Br. Med. J. 19731, 551–552

    Google Scholar 

  • Walinder, J., Skott, A., Carlsson, A., Roos, B.-E.: Potentiation by metyrosine of thioridazine effects in chronic schizophrenics. Arch. Gen. Psychiatr. 33, 501–505 (1976 a)

    Google Scholar 

  • Walinder, J., Skott, A., Nagy, A., Carlsson, A., Roos, B.-E.: Potentiation of the antidepressant action of chlomipramine by tryptophan. Arch. Gen. Psychiatr. 33, 1384–1389 (1976 b)

    Google Scholar 

  • Walters, J.R., Roth, R.H.: Dopaminergic neurons: an in vivo system for measuring drug interactions with presynaptic receptors. Naunyn Schmiedebergs Arch. Pharmacol. 296, 5–14 (1976)

    CAS  Google Scholar 

  • Young, S.N., Sourkes, T.L.: Tryptophan in the central nervous system: regulation and significance. Adv. Neurochem. 2, 133–191 (1977)

    CAS  Google Scholar 

  • Zeller, E.A., Blanksma, L.A., Burkard, W.P., Pacha, W.L., Lazanas, J.C.: In vitro and in vivo inhibition of amine oxidases. Ann. N.Y. Acad. Sci. 80, 583–590 (1959)

    PubMed  CAS  Google Scholar 

  • Zivkovic, B., Guidotti, A., Revuelta, A., Costa, E.: Effect of thioridazine, clozapine and other antipsychotics on the kinetic state of tyrosine hydroxylase and on the turnover rate of dopamine in striatum and nucleus accumbens. J. Pharmacol. Exp. Ther. 194, 37–46 (1975)

    PubMed  CAS  Google Scholar 

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  1. A. Carlsson
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Editors and Affiliations

  1. Psychiatrische Universitätsklinik, CH-8029, Zürich 8, Switzerland

    J. Angst Prof. Dr. (Forschungsdirektion) (Forschungsdirektion)

  2. Farmakologiska Institutionen, Fack, Göteborgs Universitet, S-400 33, Göteborg, Sweden

    A. Carlsson Dr.

  3. Psychiatrische und Nervenklinik, Universitäts-Krankenhaus Eppendorf, Martinistraße 52, D-2000, Hamburg 20, Germany

    J. Gross Prof. Dr.  & P. Kempe Dr.  & 

  4. Abt. Klinische Neurologie und Neurophysiologie, Klinikum der Albert-Ludwigs-Universität, Hansastr. 9, D-7800, Freiburg, Germany

    R. Jung Prof. Dr.

  5. Abt. für Klinische Neurophysiologie und Experimentelle Neurologie, Medizinische Hochschule, Karl-Wiechert-Allee 9, D-3000, Hannover 61, Germany

    H. Künkel Prof. Dr.

  6. Department of Neurosurgey, 5016 Haukeland Sykehus, N-Bergen, Norway

    L. Laitinen Dr.

  7. Psychiatrische Klinik und Poliklinik, Nervenklinik der Universität, Nußbaumstraße 7, D-8000, München 2, Germany

    N. Matussek Prof. Dr.

  8. Psykiatriska Kliniken I, Sahlgrenska Sjukhuset, Göteborgs Universitet, S-413 45, Göteborg, Sweden

    J.-O. Ottosson Prof. Dr.

  9. Deutsche Forschungsanstalt für Psychiatrie, Max-Planck-Institut für Psychiatrie, Kraepelinstraße 2 und 10, D-8000, München 40, Germany

    D. Ploog Prof. Dr.

  10. International Brain Research Organisation, KT20 7TT, Walton-on-the-Hill, GB-Tadworth, Surrey, UK

    D. Richter Prof. Dr.

  11. Psychiatrische Universitätsklinik, CH-8029, Zürich 8, Switzerland

    B. Woggon Dr. (Forschungsdirektor) (Forschungsdirektor)

  12. Max-Planck-Institut für Psychiatrie, Kraepelinstraße 2 und 10, D-8000, München 40, Germany

    E. Zerbin-Rüdin Prof. Dr.

  13. Klinik, Max-Planck-Institut für Psychiatrie, Kraepelinstraße 10, D-8000, München 40, Germany

    D. von Zerssen Prof. Dr.

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Carlsson, A. (1980). Psychopharmacology: Basic Aspects. In: Angst, J., et al. Grundlagen und Methoden der Psychiatrie. Psychiatrie der Gegenwart, vol 1 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67416-7_4

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