Action of Ganglion-Blocking Agents on the Cardiovascular System

  • D. M. Aviado
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 53)

Abstract

Until 15 years ago, the ganglion-blocking drugs were the most widely used drugs in the treatment of cardiovascular diseases. The haemodynamic action, consisting of hypotension and vasodilation, is highly desirable in the treatment of diseases such as essential hypertension, peripheral arterial insufficiency, pulmonary hypertension and pulmonary oedema.

Keywords

Bromide Nicotine Angiotensin Norepinephrine Neurol 

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References

  1. Aas, K., Biegen, E.: Effect of tetraethyl-ammonium bromide on the kidneys. Lancet 1949 MMLVI, 999–1001CrossRefGoogle Scholar
  2. Assali, N.S., Douglas, R.A., Suyemoto, R.: Observations on the hemodynamic properties of a thiophanium derivative, RO 2–2222 (Arfonad), in human subjects. Circulation 8, 62–69 (1953)PubMedGoogle Scholar
  3. Aviado, D.M.: Hemodynamic effects of ganglion-blocking drugs. Circ. Res. 8, 304–314 (1960)Google Scholar
  4. Aviado, D.M.: The lung circulation, Vol.1. Oxford, London, Edinburgh, New York, Paris, Frankfurt: Pergamon Press 1965Google Scholar
  5. Balchum, O.J., Gensini, G., Blount, S.G., Jr: Effect of hexamethonium upon the pulmonary vascular resistance in mitral stenosis. J. Lab. Clin. Med. 50, 186–198 (1957)PubMedGoogle Scholar
  6. Bazett, H.C.: The circulation. In: Medical physiology. Bart, P. (ed.). St. Louis: Mosby 1956Google Scholar
  7. Bernsmeier, A., Siemons, K.: Der Hirnkreislauf bei der gesteuerten experimentellen Hypotension (Hypotension controllee). Schweiz. Med. Wochenschr. 83, 210–212 (1953)PubMedGoogle Scholar
  8. Bessman, A.N., Alman, R. W., Fazekas, J.F.: Effect of acute hypotension on cerebral hemodynamics and metabolism of elderly patients. Arch. Intern. Med. 89, 893–898 (1952)Google Scholar
  9. Bozovic, L., Castenfords, J.: Effect of ganglionic-blocking on plasma renin activity in exercising and pain-stressed rats. Acta Physiol. Scand. 70, 290–292 (1967)PubMedCrossRefGoogle Scholar
  10. Carter, L.P., Atkinson, J.R.: Cortical blood flow in controlled hypotension as measured by thermal diffusion. J. Neurol. Neurosurg. Psychiatry 36, 906–913 (1973)PubMedCrossRefGoogle Scholar
  11. Cincotti, J., Huemer, R.: Reduction of portal hypertension by ganglionic blockade. Dig. Dis. 16, 517–521 (1971)CrossRefGoogle Scholar
  12. Crosely, A.P., Jr, Brown, J.F., Tuchman, H., Crumpton, C.W., Huston, J.H., Rowe, G.G.: Acute hemodynamic and metabolic response of hypertensive patients to pentolinium tartrate. Circulation 14, 584–592 (1956)Google Scholar
  13. Crumpton, C.W., Rowe, G.G., O’Brien, G., Murphy, Q.R., Jr: Effect of hexamethonium bromide upon coronary flow, cardiac work and cardiac efficiency in normotensive and renal hypertensive dogs. Circ. Res. 2, 79–83 (1954)PubMedGoogle Scholar
  14. Crumpton, C.W., Rowe, G.G., Capps, R.C., Whitmore, J.J., Murphy, Q.R.: Effect of hexamethonium upon cerebral blood flow and metabolism in patients with premalignant and malignant hypertension. Circulation 11, 106–109 (1955)PubMedGoogle Scholar
  15. Dewar, H.A., Owen, S.G., Jenkins, A.R.: Effect of hexamethonium bromide on the cerebral circulation in hypertension. Br. Med. J. 1953 II, 1017–1018CrossRefGoogle Scholar
  16. Eble, J.N., Gowdey, C.W., Rudzik, A.D., Vane, J.R.: Study of the mechanisms of the modifying actions of hexamethonium on the cardiovascular response to norepinephrine. J. Pharmacol. Exp. Ther. 184, 649–655 (1973)PubMedGoogle Scholar
  17. Eichna, L.W., Sobol, B.J., Kessler, R.H.: Hemodynamic and renal effects produced in congestive heart failure by the intravenous administration of a ganglionic blocking agent. Trans. A. Am. Physicians 64, 207–213 (1956)Google Scholar
  18. Elkin, M., Meng, C.H.: Angiographic study of the effect of arfonad on renal vascularity in the dog. Am. J. Roentgenol. 107, 711–719 (1969)Google Scholar
  19. Fadhel, N., Seager, L.D.: The influence of hexamethonium intracisternally and of hexamethonium and trimethaphan camphorsulfonate intravenously on the pressor responses to intracis-ternal veratrine. Proc. Soc. Exp. Biol. Med. 131, 1263–1269 (1969)PubMedGoogle Scholar
  20. Fazekas, J.F., Albert, S.N., Alman, R.W.: Cerebral physiology of controlled hypotension. Arch. Surg. 73, 59–62 (1956)Google Scholar
  21. Finnerty, F.A., Jr, Witkin, L., Fazekas, J.F.: Cerebral hemodynamics during cerebral ischemia induced by acute hypotension. J. Clin. Invest. 33, 1227–1232 (1954)PubMedCrossRefGoogle Scholar
  22. Finnerty, F.A., Jr Guillaudeu, R.L., Fazekas, J.F.: Cardiac and cerebral hemodynamics in drug induced postural collapse. Circ. Res. 5, 35–39 (1957)Google Scholar
  23. Ford, R.V., Moyer, J.H., Spurr, C.L.: Hexamethonium in the chronic treatment of hypertension; its effect on renal hemodynamics and on the excretion of water and electrolytes. J. Clin. Invest. 32, 1133–1139(1953)PubMedCrossRefGoogle Scholar
  24. Fowler, N.O., Westcott, R.N., Hauenstein, V.D., Scott, R.C., McGuire, J.: Observations on autonomic participation in pulmonary arteriolar resistance in man. J. Clin. Invest. 29, 1387–1396 (1950)PubMedCrossRefGoogle Scholar
  25. Freis, E.D., Rose, J.C., Partenope, E.A., Higgins, T.F., Kelley, R.T., Schnaper, H.W., Johnson, R.L.: Hemodynamic effects of hypotensive drugs in man. III. Hexamethonium. J. Clin. Invest. 32, 1285–1298(1953)PubMedCrossRefGoogle Scholar
  26. Frisk, A.R., Hammarstrom, S., Lagerlof, H., Werko, L., Bjorkenheim, G., Holmgren, A., Larsson, Y.: Effect of tetraethylammonium in arterial hypertension. Am. J. Med. 5, 807–814 (1948)PubMedCrossRefGoogle Scholar
  27. Gelman, S.I.: The effect of ganglionic block on hepatic circulation. Biull. Eksp. Biol. Med. 76, 9–11(1973)Google Scholar
  28. Green, H.D., Kepchar, J.H.: Control of peripheral resistance in major systemic vascular beds. Physiol. Rev. 39, 617–686 (1959)PubMedGoogle Scholar
  29. Grob, D., Scarborough, W.R., Kattus, A.A., Jr, Langford, H.G.: Further observations on the effects of autonomic blocking agents in patients with hypertension. II. Hemodynamic, ballistocardiographic, and electrocardiographic effects of hexamethonium and pentamethonium. Circulation 8, 352–369 (1953)PubMedGoogle Scholar
  30. Halmagy, D., Felkai, B., Ivanyi, J., Zsoter, T., Tenyi, M., Szucs, Z.S.: Role of the nervous system in the maintenance of pulmonary arterial hypertension in heart failure. Br. Heart. J. 15, 15–24 (1953)CrossRefGoogle Scholar
  31. Hilton, J.G., Steinberg, M.: Effects of ganglion- and parasympathetic-blocking drugs upon the pressor response elicited by elevation of the intracranial fluid pressure. J. Pharmacol. Exp. Ther. 153, 285–291 (1966)Google Scholar
  32. Hoobler, S.W., Malton, S.D., Ballantine, H.T., Cohen, S., Neligh, R.B., Peet, M.M., Lyons, R.H.: Studies on vasomotor tone. I. Effect of the tetraethylammonium ion on the peripheral blood flow of normal subjects. J. Clin. Invest. 28, 638–647 (1949)CrossRefGoogle Scholar
  33. Horwitz, O., Montgomery, H., Longaker, E.D., Sayen, A.: Effects of vasodilator drugs and other procedures on digital cutaneous blood flow, cardiac output, blood pressure, pulse rate, body temperature, and metabolic rate. Am. J. Med. Sci. 218, 669–682 (1949)PubMedCrossRefGoogle Scholar
  34. Kleh, J., Fazekas, J.F.: Effects of hypotensive agents on subjects with cerebral vascular insufficiency. J. Am. Geriatr. Soc. 4, 18–23 (1956)PubMedGoogle Scholar
  35. Landysheva, I.V., Zavolovskaya, L.I., Katyukhin, V.N.: Effect of hexonium and hexamethonium on the pulmonary circulation and the contractile function of the myocardium. Ter. Arkh. 44, 54–60 (1972) (Russ.)PubMedGoogle Scholar
  36. Lee, W.C., Shideman, F.E.: Inotropic action of hexamethonium. Circ. Res. 6, 66–71 (1958)PubMedGoogle Scholar
  37. Lewis, J.A., Deshmankar, B.S.: A reappraisal of vascular effects of hexamethonium. Can. J. Physiol. Pharmacol. 46, 139–143 (1968)PubMedCrossRefGoogle Scholar
  38. Mackinnon, J.: Effect of hypotension-producing drugs on the renal circulation. Lancet 1952 MMLXIII, 12–15CrossRefGoogle Scholar
  39. Magness, A., Yashon, D., Locke, G., Wiederholt, W., Hunt, W.E.: Cerebral function during trimethaphan-induced hypotension. Neurology 23, 506–509 (1973)PubMedGoogle Scholar
  40. Miles, B.E., Dewardener, H.E., Churchill-Davidson, H.C., Wylie, W.D.: Effect on the renal circulation of pentamethonium bromide during anaesthesia. Clin. Sci. 11, 73–79 (1952)PubMedGoogle Scholar
  41. Morris, G.C., Jr, Moyer, J.H., Snyder, H.B., Haynes, B.W., Jr: Vascular dynamics in controlled hypotension. Ann. Surg. 138, 706–711 (1953)PubMedCrossRefGoogle Scholar
  42. Moyer, J.H., Handley, C.A.: Renal and cardiovascular hemodynamic response to ganglionic blockade with pendiomide and comparison with hexamethonium and arfonad. J. Pharmacol. Exp. Ther. 113, 383–392 (1955)PubMedGoogle Scholar
  43. Moyer, J.H., Morris, G.: Cerebral hemodynamics during controlled hypotension induced by the continuous infusion of ganglionic blocking agents (hexamethonium, pendiomide, and arfonad). J. Clin. Invest. 33, 1081–1088 (1954)PubMedCrossRefGoogle Scholar
  44. Moyer, J.H., Ford, R., Dennis, E., Handley, C.A.: Laboratory and clinical observations on mecamylamine as a hypotensive agent. Proc. Soc. Exp. Biol. Med. 90, 402–408 (1955)PubMedGoogle Scholar
  45. Moyer, J.H., McConn, R., Morris, G.C.: Effect of controlled hypotension with pendiomide (as used in surgery) on renal hemodynamics and water and electrolyte excretion — a comparison with hexamethonium and arfonad and the effect of norepinephrine on these responses. Anesthesiology 16, 355–364 (1955)PubMedCrossRefGoogle Scholar
  46. Moyer, J.H., McConn, R., Seibert, R.A.: Effect of blood pressure reduction with arfonad on renal hemodynamics and the excretion of water and electrolytes in patients with hypertension. Am. Heart J. 49, 360–366 (1955)PubMedCrossRefGoogle Scholar
  47. Moyer, J.H., Morris, G., Seibert, R.A.: Renal function during controlled hypotension with hexamethonium and following norepinephrine. Surg. Gynecol. Obstet. 100, 27–32 (1955)PubMedGoogle Scholar
  48. Needleman, H.L., Horwitz, O.: Comparative study of the effects of three vasodilator drugs, pentamethonium bromide (C5), Dilatol (SKF-1700-A) and pendiomide (BA-9295) on the digital cutaneous blood flow. Am. J. Med. Sci. 226, 164–171 (1953)PubMedCrossRefGoogle Scholar
  49. Parrish, A.E., Kleh, J., Fazekas, J.F.: Renal and cerebral hemodynamics with hypotension. Am. J. Med. Sci. 233, 35–39 (1957)PubMedCrossRefGoogle Scholar
  50. Pedersoli, W.H.: Effects of ganglionic and cholinergic blocking drugs on the pressor response to central vagal stimulation. Pharmacology 4, 120–128 (1970)PubMedCrossRefGoogle Scholar
  51. Plummer, A.J., Trapold, J.H., Schneider, J.A., Maxwell, R.A., Earl, A.E.: Ganglionic blockade by a new bis-quaternary series including chlorisondamine dimethochloride. J. Pharmacol. Exp. Ther. 115, 172–184(1955)PubMedGoogle Scholar
  52. Pokk, L.R.: Hexamethonium action on the development of myocardial necroses. Farmakol. Toksikol. 35, 193–195 (1972)PubMedGoogle Scholar
  53. Rakita, L., Sancetta, S.M.: Acute hemodynamic effects of hexamethonium in normotensive man. Circ. Res. 1, 499–501 (1953)PubMedGoogle Scholar
  54. Redisch, W., Wertheimer, L., Delisle, C., Steele, J.M.: Comparison of visceral and peripheral vascular beds in hypertensive patients. Circulation 9, 68–72 (1954)PubMedGoogle Scholar
  55. Restall, P.A., Smirk, F.H.: Regulation of blood pressure levels by hexamethonium bromide and mechanical devices. Br. Heart J. 14, 1–12 (1952)PubMedCrossRefGoogle Scholar
  56. Reynolds, T.B., Paton, A., Freeman, M., Howard, F., Sherlock, S.: Effect of hexamethonium bromide on splanchnic blood flow, oxygen consumption, and glucose output in man. J. Clin. Invest. 32, 793–800 (1953)PubMedCrossRefGoogle Scholar
  57. Sancetta, S.M.: Acute hemodynamic effects of hexamethonium (C6) in patients with emphysematous pulmonary hypertension. Am. Heart. J. 49, 501–506 (1955)PubMedCrossRefGoogle Scholar
  58. Sancetta, S.M.: Acute hemodynamic effects of total head-down body tilt and hexamethonium in normal and pulmonary emphysematous subjects. J. Lab. Clin. Med. 49, 684–693 (1957)PubMedGoogle Scholar
  59. Schnaper, H.W., Johnson, R.L., Tuohy, E.B., Freis, E.D.: Effects of hexamethonium as compared to procaine or metacaine lumbar block on the blood flow to the foot of normal subjects. J. Clin. Invest. 30, 786–791 (1951)PubMedCrossRefGoogle Scholar
  60. Scott, R.C., Kaplan, S., Stiles, W.J.: Observations on the effect of tetraethylammonium chloride on the pulmonary vascular resistance in mitral stenosis. Am. Heart J. 50, 720–730 (1955)PubMedCrossRefGoogle Scholar
  61. Shackman, R., Graber, I.G., Melrose, D.G., Smith, J.: Hemodynamics of methonium hypotension during anaesthesia. Anaesthesia 7, 217–222 (1952)PubMedCrossRefGoogle Scholar
  62. Shell, W.E., Sobel, B.E.: Protection of jeopardized ischemic myocardium by reduction of ventricular afterload. N. Engl. J. Med. 291, 481–486 (1974)PubMedCrossRefGoogle Scholar
  63. Smith, J.R., Agrest, A., Hoobler, S.W.: Effect of acute and chronic administration of pentolinium tartrate on the blood pressure and cardiac output in hypertensive patients. Circulation 12, 777 (1955)Google Scholar
  64. Sobol, B.J., Kessler, R.H., Rader, B., Eichna, L.W.: Cardiac, hemodynamic and renal functions in congestive heart failure during induced peripheral vasodilatation; relationship to Starling’s law of the heart in man. J. Clin. Invest. 38, 557–578 (1959)PubMedCrossRefGoogle Scholar
  65. Steinberg, M., Hilton, J.G.: Site of action of atropine in blocking pressor response to increased intracranial pressure in chlorisondamine-treated dogs. Tex. Rep. Biol. Med. 24, 222–227 (1966 a)PubMedGoogle Scholar
  66. Steinberg, M., Hilton, J.G.: Effects of chlorisondamine and atropine on cardiovascular responses to stimulation of the carotid sinuses. Tex. Rep. Biol. Med. 24, 693–699 (1966 b)Google Scholar
  67. Steinberg, M., Hilton, J.G.: Effect of sympathectomy and adrenalectomy upon ganglion blockade. Pharmacol. Exp. Ther. 156, 215–220 (1967)Google Scholar
  68. Stone, H.H., Mackrell, T.N., Wechsler, R.L.: Effect on cerebral circulation and metabolism in man of acute reduction in blood pressure by means of intravenous hexamethonium bromide and head-up tilt. Anesthesiology 16, 168–176 (1955)PubMedCrossRefGoogle Scholar
  69. Storstein, O., Tveten, H.: Effect of hexamethonium bromide on the pulmonary circulation. Scand. J. Clin. Lab. Invest. 6, 169–177 (1954)PubMedCrossRefGoogle Scholar
  70. Traber, D.L., Wilson, R.D., Priano, L.L.: The effect of autonomic blocking agents on the cardiovascular response to etoxadrol (CL 1848-C). 1. Ganglionic blockade. Arch. Int. Pharmacodyn. 204, 333–341 (1973)PubMedGoogle Scholar
  71. Trapold, J.H.: Effect of ganglionic-blocking agents upon blood flow and resistance in the superior mesenteric artery of the dog. Circ. Res. 4, 718–723 (1956)PubMedGoogle Scholar
  72. Trapold, J.H.: Role of venous return in the cardiovascular response following injection of ganglion-blocking agents. Circ. Res. 5, 444–450 (1957)PubMedGoogle Scholar
  73. Ulimann, T.D., Diengott, D.: Effect of hexamethonium (C6) on renal hemodynamics in man. Arch. Intern. Med. 92, 228–237 (1953)Google Scholar
  74. Ullmann, T.D., Menczel, J.: Effect of a ganglionic blocking agent (hexamethonium) on renal function and on excretion of water and electrolytes in hypertension and in congestive heart failure. Am. Heart. J. 52, 106–120 (1956)PubMedCrossRefGoogle Scholar
  75. Van Bergen, F.H.: Hexamethonium-induced hypotension. Minn. Med. 38, 573–576 (1955)Google Scholar
  76. Vanevsky, F.L., Azarov, V.I.: On the effect of vasoconstricting agents on hemodynamics under conditions of ganglionary blockade during the operation and general anesthesia. Vestn. Khir. 110, 80–83 (1973) (Russ.)Google Scholar
  77. Varnauskas, E.: Studies in hypertensive cardiovascular disease with special reference to cardiac function. Scand. J. Clin. Lab. Invest. 7, 5–117 (1955)Google Scholar
  78. Vinogradov, A.V., Tsibermakler, T.D.: Hemodynamic changes occurring in cardiac insufficiency under the influence of hexonium. Kardiologiia 6, 34–38 (1966) (Russ.)Google Scholar
  79. Werko, L., Frisk, A.R., Wade, G., Ellasch, H.: Effect of hexamethonium bromide in arterial hypertension. Lancet 1951 II, 470–472CrossRefGoogle Scholar
  80. Wilson, V.H., Keeley, K.J.: Haemodynamic effects of hexamethonium bromide in patients with pulmonary hypertension and heart failure. S. Air. J. Med. Sci. 18, 125–129 (1953)Google Scholar
  81. Yu, P.N., Nye, R.E., Jr, Lovejoy, F.W., Jr, Schreiner, B.F., Yim, B.J.B.: Studies of pulmonary hypertension. IX. Effects of intravenous hexamethonium on pulmonary circulation in patients with mitral stenosis. J. Clin. Invest. 37, 194–201 (1958)PubMedCrossRefGoogle Scholar

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  • D. M. Aviado

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