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Pharmacology of Ganglionic Transmission pp 385–410Cite as

Ganglionic Actions of Anticholinesterase Agents, Catecholamines, Neuro-Muscular Blocking Agents, and Local Anaesthetics

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 53))

Abstract

The demonstration by Feldberg and Gaddum (1934) that acetylcholine is the transmitter in sympathetic ganglia was a milestone in the development of the concept of chemical transmission. Clearly, the isolation of acetylcholine from the fluid perfusing the ganglia constitutes an important part of the evidence supporting the concept that chemical substances mediate synaptic transmission. It should be noted, however, that the recovery of acetylcholine from the perfusion stream is not possible unless an anticholinesterase agent is present in the perfusion fluid. In the absence of the enzyme inhibitor, choline appears in the perfusion fluid as a consequence of the hydrolysis of acetylcholine. Thus, the acetylcholinesterase enzymes destroy acetylcholine and, therefore, can serve to limit the biological life of the transmitter. Koelle (1963) and Zaimis (1963) give complete accounts of the earlier studies of the effects of anticholinesterase agents on ganglionic transmission and are useful reference sources for the period between the 1930s and 1960s.

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  1. R. L. Volle
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  1. Department of Pharmacology, First Medical Institute, 2/6, B. Pirogovskaja St., 119435, Moscow, USSR

    Dimitry A. Kharkevich

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Volle, R.L. (1980). Ganglionic Actions of Anticholinesterase Agents, Catecholamines, Neuro-Muscular Blocking Agents, and Local Anaesthetics. In: Kharkevich, D.A. (eds) Pharmacology of Ganglionic Transmission. Handbook of Experimental Pharmacology, vol 53. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67397-9_14

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  • DOI: https://doi.org/10.1007/978-3-642-67397-9_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-67399-3

  • Online ISBN: 978-3-642-67397-9

  • eBook Packages: Springer Book Archive

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