Abstract
Studies of experimental gastric cancer have markedly progressed over the last 10 years. Sugimura and Fujimura [10] first produced gastric cancer in rats by treatment of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). Subsequently, similar gastric cancers were produced in hamsters [2] and dogs [12] by MNNG. N-ethyl-N′-nitro-N-nitrosoguanidine (ENNG), the homologue of MNNG, was also found to be effective in producing gastric cancer in the same species [11, 3]. Experimental gastric cancer of dogs showed histologic features quite similar to those of human gastric cancer, metastasized to regional lymph nodes or other organs and was transplantable to nude mice [13].
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Saito, T., Sasaki, O., Matsukuchi, T., Iwamatsu, M., Inokuchi, K. (1979). Experimental Gastric Cancer: Pathogenesis and Clinico-Histopathologic Correlation. In: Herfarth, C.H., Schlag, P.M. (eds) Gastric Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67368-9_5
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DOI: https://doi.org/10.1007/978-3-642-67368-9_5
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