Abstract
In the strict sense of the term, biological markers of tumors are substances — such as enzymes, hormones, or antigens — which are produced by the respective tumor and released into the body fluids where they may be detected. However, in a broader sense, the term includes characteristic reactions of the organism against the tumor, such as the formation of antibodies or cellular immune factors to tumor antigens. There are several examples of the successful application of such biological markers for the diagnosis or postoperative follow-up of human malignancies: the determination of AFP in liver carcinoma [13], of β-HCG in chorionic carcinoma [15], of CEA in colon carcinoma [14], and of EBV-antibodies in Burkitt lymphoma [9].
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References
Björklund, B.: Tissue polypeptide antigen; review of physical chemistry and clinical application. In: Clinical application of carcinoembryonic antigen assay. Krebs, B. P., Lalanne, C. M., Schneider, M. (eds.), pp. 59–63. Amsterdam, Oxford: Excerpta Medica 1978
Bone, G., Lauder, I.: Cellular immunity, peripheral blood lymphocyte count and pathological staging of tumours in the gastrointestinal tract. Cancer 30, 215–221 (1974)
Bone, G., Appleton, D. R., Venables, C. W.: Cutaneous delayed hypersensitivity responses to 2–4 dinitrochlorobenzene — a prognostic guide in malignant disease. Br. J. Surg. 60, 906 (1973)
Costanza, M. E., Das, S., Nathanson, L., Rule, A., Schwartz, R. S.: Carcinoembryonic antigen. Cancer 33, 583–590(1974)
Daver, A., Wafflart, J., Ben Boueli, A., Minier, J. F., Larra, F.: β2-microglobulin (β2-micro) and carcinoembryonic antigen (CEA) in intestinal cancers — a correlation with stage of disease. In: Clinical application of carcinoembryonic antigen assay. Krebs, B. P., Lalanne, C. M., Schneider, M. (eds.), pp. 460–465. Amsterdam, Oxford: Excerpta Medica 1978
Fuks, A., Banjo, Ch., Shuster, J., Freedmann, S. O., Gold, P.: Carcinoembryonic antigen (CEA): Molecular biology and clinical significance. Biochem. Biophys. Acta 417, 123–152 (1974)
Hamasaki, K.: Cell-mediated immunity against digestive organ cancers: leukocyte migration inhibitory factor activity as an immunological parameter. Acta Med. Okayama 31, 147–159 (1977)
Hansen, H. J., Snyder, J. J., Miller, E., Vandevoorde, J. P., Miller, O. N., Hines, L. R., Burns, J. J.: Carcinoembryonic antigen (CEA) assay. Hum. Pathol. 5, 139–147 (1974)
Henle, W., Henle, G., Gunvin, P., Klein, G., Clifford, P., Single, S.: Patterns of antibodies to Epstein-Barr-Virus induced early antigens in Burkitt’s lymphoma. Comparison of dying patients with long-term survivors. J. Natl. Cancer Inst. 50, 1163 (1973)
Johnson, M. W., Maibach, H. I., Salmon, S. E.: Skin reactivity in patients with cancer. Impaired delayed hypersensitivity or faulty inflammatory response? N. Engl. J. Med. 284, 1255–1257 (1971)
Klein, G.: Tumour antigens. Biochem. Soc. Trans. 4, 8–9 (1976)
Lamerz, R., Fateh-Moghadam, A.: Carcinofetale Antigene. III. Andere Carcinofetale Antigene. Klin. Wochenschr. 53, 403–417 (1975)
Lamerz, R., Fateh-Moghadam, A.: Carcinofetale Antigene. I. Alpha-Fetoprotein. Klin. Wochenschr. 53, 147–169 (1975)
Lehmann, F. G.: Serologische Tumordiagnostik. Internist (Berlin) 16, 214–222 (1975)
Lehmann, F. G.: Kongreßbericht: 5th meeting of the International Research Group of Carcino-Embryonic Proteins (IRGCP). Inn. Med. 4, 388–390 (1977)
Gerfo, P., Pennington, G.: Current status of carcinoembryonic antigen. Prog. Clin. Cancer 6, 65–71(1975)
Martin, E. W., James, K. K., Hurtubise, P. E., Catalano, P., Minton, J. P.: The use of CEA as an early indicator for gastrointestinal tumor recurrence and second-look procedures. Cancer 39, 440–446(1977)
Pant, K. D., Dahlman, H. L., Goldenberg, D. M.: A putatively new antigen (CSAp) associated with gastrointestinal and ovarian neoplasia. Immunol. Commun. 6, 411–421 (1977)
Pappas, A., Scheurlen, P. G.: Lymphocyte transformation in malignant diseases. Communication II: Results in reticulo- and lymphoproliferative diseases as well as in carcinomas. In: Applied tumor immunology. Götz, H., Bücherl, E. S. (eds.), pp. 305–331. Berlin, New York: de Gruyter 1975
Rapp, W., Matzku, S., Wurster, K. H.: Stand der Isolierung CEA-ähnlicher Substanzen aus menschlicher Tumormagenschleimhaut. In: Tumorantigene in der Gastroenterologie. Lehmann, F. G. (ed.), pp. 39–43. Gräfelfing: Demeter 1976
Staab, H. J., Anderer, F. A., Stumpf, E., Fischer, R.: Second-look surgery of gastrointestinal carcinoma and the potential value of CEA monitoring. In: Clinical application of carcinoembryonic antigen assay. Krebs, B. P., Lalanne, C. M., Schneider, M. (eds.), pp. 94–100. Amsterdam, Oxford: Excerpta Medica 1978
Stillman, A., Zamcheck, N.: Recent advances in immunologic diagnosis of digestive tract cancer. Digest. Dis. 15, 1003–1018 (1970)
Trejdosiewicz, L. K., Dykes, P. W.: And-tumour monocyte activity in gastric carcinoma patients receiving intra-tumoral C. parvum. In: The macrophage and cancer. James K., McBride, B., Stuart, A. (eds.), pp. 426–437. Edinburgh: Econoprint 1977
Vuento, M., Ruoslahti, E., Pihko, H., Svenberg, T., Ihamäki, T., Siurala, M.: Carcinoembryonic antigen-like substance in gastric juice. Immunochemistry 13, 313–316 (1976)
Zöller, M., Matzku, S., Lernhardt, W., Schulz, U.: Evaluation of different antigen sources for leukocyte migration testing of gastrointestinal cancer patients. In: Clinical application of carcinoembryonic antigen assay. Krebs, B. P., Lalanne, C. M., Schneider, M. (eds.), pp. 155–160. Amsterdam, Oxford: Excerpta Medica 1978
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Heymer, B., Quentmeier, A. (1979). Biological Markers for Staging of Gastric Cancer?. In: Herfarth, C.H., Schlag, P.M. (eds) Gastric Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67368-9_23
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DOI: https://doi.org/10.1007/978-3-642-67368-9_23
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