Abstract
Several recent reviews of the epidemiology of gastric cancer are available [3, 4]. One of the salient features brought out is the prolonged latency period of the disease which in most cases is in excess of 30 years. During the prolonged latency period, drastic changes take place in the gastric microenvironment. The purpose of this article is to review briefly our present knowledge concerning the altered microenvironment.
Work supported by contracts NO 1-CP-53521 and NO 1-CP-33286
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References
Correa, P., Cuello, C., Duque, E.: Carcinoma and intestinal metaplasia of the stomach in Colombian migrants. J. Natl. Cancer Inst. 44, 297–306 (1970)
Correa, P., Haenszel, W., Cuello, C., Tannenbaum, S., Archer, M.: A model for gastric cancer epidemiology. Lancet 1975 2, 58
Correa, P., Cuello, C., Haenszel, W.: Pathogenese des Magenkarzinoms — Epidemiologische Pathologie vorangehender Lasionen. Leber Magen Darm 6, 72–79 (1976)
Correa, P., Cuello, C., Haenszel, W.: Epidemiology of premalignant gastric lesions. In: Pathophysiology of carcinogenesis in digestive organs. Farber, E. et al. (ed.)., pp. 163–179. Baltimore: Park Press 1977
Hawksworth, G., Hill, M. J., Gordillo, G., Cuello, C.: Possible relationship between nitrates, nitrosamines and gastric cancer in South-West Colombia. In: N-Nitroso compounds in the environment. Vol. 9, pp. 229–234. Bogovski, P., Walker, E. A. (eds.). Lyon, France: IARC Scientific Publication 1974
Jones, S. M., Davies, P. W., Savage, A.: Gastric juice nitrite and gastric cancer. Lancet 1978 1, 1355
Kokatnur, M., Murray, M., Correa, P.: Mutagenic properties of nitrosated spermidine. Proc. Soc. Exp. Biol. Med. 158, 85–88 (1978)
Montes, G., Gordillo, G., Cuello, C., Pelon, W., Johnson, W., Correa, P.: Mutagenic activity of gastric juice. Submitted for publication, Cancer Lett. (1979)
Ruddel, W. S. J., Bone, E. S., Hill, M. J., Walter, C. L.: Gastric juice nitrite. A risk factor in the hypochlorhydric stomach? Lancet 1976 2, 1037–1039
Tannenbaum, S. R., Archer, M. C., Wishnok, J. S., Correa, P., Cuello, C., Haenszel, W.: Nitrate and the etiology of gastric cancer. In: Origins of human cancer. pp. 1609–1625. Cold Spring: Harbor Laboratories 1977
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Correa, P., Cuello, C., Montes, G. (1979). Pathogenesis of Gastric Carcinoma: The Role of the Microenvironment. In: Herfarth, C.H., Schlag, P.M. (eds) Gastric Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67368-9_2
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DOI: https://doi.org/10.1007/978-3-642-67368-9_2
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