Abstract
Nitrosamines are among the most potent chemical carcinogens known [6, 12] with which, at least in animal experiments, the induction of gastric cancer could be demonstrated [21, 25]. It has been suggested that nitrite and secondary amines present in food might react with each other in the environment of the human stomach to form these carcinogens [18, 20, 23]. Because in food stuffs secondary amines are in general present, intragastric nitrosamine formation occurs if there is a sufficient nitrite concentration in the gastric juice. The intragastric bacterial reduction of nitrate to nitrite is therefore very important [9, 15]. Bacterial overgrowth of the small bowel has been demonstrated after gastric surgery [1, 3, 5, 7, 8]. However, until now, little attention has been paid to the influence of the operative technique on the bacterial flora of the gastric juice [14, 22]. Concerning the cancer risk of the operated stomach [4], it was the aim of our investigation to evaluate experimentally the influence of different operative techniques on the composition of the bacterial gastric flora. In particular, we were interested in the production of bacterial nitrites in the stomach with respect to formation of carcinogenic nitrosamines.
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Schlag, P., Böckler, R., Meyer, H., Belohlavek, D. (1979). Nitrite and N-Nitrosocompounds in the Operated Stomach. In: Herfarth, C.H., Schlag, P.M. (eds) Gastric Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67368-9_17
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DOI: https://doi.org/10.1007/978-3-642-67368-9_17
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