Biological Significance of Dysplasias of the Epithelium and of Atrophic Gastritis

  • W. Oehlert
Conference paper

Abstract

Systematic investigations on resected specimens carried out by Büchner [1] and Konjetzny [15, 16] during the 1920s and 1930s, have proved that particular cellular alterations occur very regularly in the vicinity of carcinomas of the stomach, and that these may be regarded as forming the earlier stages. This assumption of the earlier investigators was confirmed by findings obtained by light and electron microscopic examinations from different stages of the experimental carcinogenesis of the stomach in the rat and in the dog [13, 33]. These changes of the gastric mucosa are now commonly recognized as precancerous lesions. The definition of precancerous lesions covers alterations like chronic gastritis accompanied by mucosal atrophy and intestinal metaplasia. It also refers, however, to advanced processes of dedifferentiation of the gastric mucosa, as for example the borderline lesion [20], a proliferation of the glandular neck cells associated with atypical forms [9], the different varieties of dysplasia [11, 24, 20] and the carcinoma of the surface or intra-epithelial carcinoma [19, 28] or the carcinoma in situ, respectively [3]. From the scientific point of view, it might be interesting to find out whether these changes of the gastric mucosa within the resected specimens of the stomach are to be defined as facultative or obligatory precancerous lesions, but this is of no consequence to the treatment of the individual patient.

Keywords

Migration Lymphoma Anemia Nitrite Candida 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Büchner, F.: Die Histologie der peptischen Veränderungen und ihre Beziehungen zum Magenkarzinom. Veroeff. Kriegspathol. Konstitutionspathol. 18, 1–125 (1927)Google Scholar
  2. 2.
    Correa, P., Cuello, C., Haenszel, W.: Epidemiology of premalignant gastric lesions, pp. 107–120. Tokyo: University Press 1977Google Scholar
  3. 3.
    Crespi, M., Bigotti, A., di Matteo, S.: Early gastric cancer. Grundmann, E., Grunze, H., Witte, S. (eds.), p. 60. In: early gastric cancer. Berlin, Heidelberg, New York: Springer 1974Google Scholar
  4. 4.
    Deschner, E. E., Lipkin, M.: Proliferation and differentiation of gastrointestinal cells in health and disease. In: Gastrointestinal tract cancer. Lipkin, M., Good, R. A., (eds.), pp. 3–24. New York, London: Plenum Medical Book 1978Google Scholar
  5. 5.
    Domellöf, L., Eriksson, S., Janunger, K. G.: Late occurrence of precancerous changes and carcinoma of the gastric stump after Billroth II resection. Acta Chir. Scand. 141, 292 – 297 (1975)PubMedGoogle Scholar
  6. 6.
    Eastwood, G. L.: Progress in gastroenterology: Gastrointestinal epithelial renewal. Gastroenterology 72, 962 (1977)PubMedGoogle Scholar
  7. 7.
    Elster, K., Kudlich, W.: Die diagnostische Effektivität der Gastrobiopsie. Endoscopy 4, 162 (1972)Google Scholar
  8. 8.
    Elster, K.: False diagnosis in the diagnostics of early gastric cancer. In: Early gastric cancer. Grundmann, Grunze, Witte (eds.), p. 58. Berlin, Heidelberg, New York: Springer 1974Google Scholar
  9. 9.
    Elster, K.: Diskussion zum Thema: Magenfrühkarzinom. Therapiewoche 28, 4996 (1978)Google Scholar
  10. 10.
    Fujita, S., Hattori, T.: Cell proliferation, differentiation and migration in the gastric mucosa: A study on the background of carcinogenesis. In: Pathophysiology of carcinogenesis in digestive organs. Farber, E. et al. (eds.), pp. 21–36. Tokyo: University Press 1977Google Scholar
  11. 11.
    Grundmann, E.: Histologic types and possible initial stages in early gastric carcinoma. Beitr. Pathol. 154, 256 (1975)PubMedGoogle Scholar
  12. 12.
    Heilmann, K. L., Gastritis — Intestinale Metaplasie — Karzinom. Vergleichende quantitative und qualitative morphologische Untersuchungen. In: Gastroenterologie und Stoffwechsel. Bartelheimer, H., Kühn, H. A., Becker, V., Stelzner, F. (eds.), Vol. 13. Stuttgart: Thieme 1978Google Scholar
  13. 13.
    Kobori, O., Gedigk, P., Totovic, V.: Early changes of glandular stomach in Wistar Rats ingesting N-methyl-N′-nitro-N-nitrosoguanidine (MNNG): With special reference to light microscopic, electron microscopic, and enzyme histochemical study of the regenerating epithelium induced by MNNG. Z. Krebsforsch. 87, 87 (1976)CrossRefGoogle Scholar
  14. 14.
    Konjetzny, G. E.: Der Magenkrebs. Stuttgart: 1938Google Scholar
  15. 15.
    Konjetzny, G. E.: Der oberflächliche Schleimhautkrebs des Magens. Chirurg. 191, 192 (1940)Google Scholar
  16. 16.
    Marks, J., Shuster, S.: The skin and gastrointestinal malignancy. In: Gastrointestinal Tract Cancer. Lipkin, M., Good, R. A. (eds.), pp. 509–534. New York, London: Plenum Medical Book 1978Google Scholar
  17. 17.
    Mason, M. K.: Surface carcinoma of the stomach. Gut 6, 185 (1965)PubMedCrossRefGoogle Scholar
  18. 18.
    Ming, S. C.: Dysplasias of the stomach. International Conference of Gastrointestinal Cancer 1977. Basel, München, Paris, London, New York, Sydney: Karger 1977Google Scholar
  19. 19.
    Nagayo, T.: Microscopical cancer of the stomach. A study on histogenesis of gastric carcinoma. Int. J. Cancer 16, 52 (1975)PubMedCrossRefGoogle Scholar
  20. 20.
    Nagayo, T.: Precursors of human gastric cancer: Their frequencies and histological characteristics, pp. 151 – 161. Tokyo: University Press 1977Google Scholar
  21. 21.
    Oehlert, W., Keller, P., Henke, M., Strauch, M.: Die Dysplasien der Magenschleimhaut. Das Problem ihrer klinischen Bedeutung. Dtsch. Med. Wochenschr. 100, 1950 (1975)PubMedCrossRefGoogle Scholar
  22. 22.
    Oehlert, W.: Klinische Pathologie des Magen-Darmtraktes. Stuttgart: Schattauer 1978Google Scholar
  23. 23.
    Orita, K., Kobayashi, M., Uchida, Y., Yumara, M., Yamamoto, I., Fukuda, H., Kaneda, S., Mammami, T., Kokuma, Y., Tanaka, S.: Reduction of concomitant cell-mediated immunity level in advanced cancer patients. Cancer immunology. GANN Monogr. Cancer Res. 16, 141 (1974)Google Scholar
  24. 24.
    Piessens, W. F.: Evidence for human cancer immunity. A review. Cancer 26, 1212 (1970)Google Scholar
  25. 25.
    Saito, T., Sasaki, O., Tamada, R., Iwamatsu, M., Matsukuchi, T., Inokuchi, K.: Follow-up studies of experimental stomach cancer in dogs. In: Pathophysiology of carcinogenesis in digestive organs. Farber, E. et al. (eds.), pp. 107 – 120. Tokyo: University Press 1977Google Scholar
  26. 26.
    Schade, R. O. K.: The borderline between benign and malignant lesions in the stomach. In: Early gastric cancer, Grundmann, E., Grunze, H., Witte, S. (eds.), p. 45. Berlin, Heidelberg, New York: Springer 1974Google Scholar
  27. 27.
    Seifert, E., Dittrich, H., Erd, W.: Gastrobioptische Untersuchungen am Resektionsmagen. Med. Welt 17, 38–44(1966)Google Scholar
  28. 28.
    Serck-Hansen, A., Schrumpf, E., Stadaas, J., Myren, J., Osnes, M.: Mucosal changes in the gastric stump 20–25 years after resection for ulcer. A follow-up study. International Conference of Gastrointestinal Cancer 1977, p. 273. Basel, München, Paris, London, New York, Sydney: Karger 1977Google Scholar
  29. 29.
    Siurala, M., Villako, K., Ihamäki, T., Kekki, M., Lehtola, J., Sipponen, P., Varis, K.: Atrophic gastritis. Its genetic and dynamic behavior and its relations to gastric carcinoma and pernicious anemia. In: Pathophysiology of carcinogenesis in digestive organs. Farber, E. et al. (eds.), pp. 135–150. Tokyo: University Press 1977Google Scholar
  30. 30.
    Spector, B. D., Good, R. A., Kersey, J. H.: Immunodeficiency diseases and malignancy. In: Gastrointestinal tract cancer. Lipkin, M., Good, R. A. (eds.), pp. 51–67. New York, London: Plenum Medical Book 1978Google Scholar
  31. 31.
    Sugimura, T., Kawachi, T.: Experimental stomach carcinogenesis. In: Gastrointestinal tract cancer. Lipkin, M., Good, R. A. (eds.), pp. 327–337. New York, London: Plenum Medical Book 1978Google Scholar
  32. 32.
    Twomey, J. J.: Immunological dysfunction with atrophic gastritis and gastric malignant. In: Gastrointestinal tract cancer. Lipkin, M., Good, R. A. (eds.), pp. 93–111. New York, London: Plenum Medical Book 1978Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1979

Authors and Affiliations

  • W. Oehlert

There are no affiliations available

Personalised recommendations