Zusammenfassung
Jeder Vielzeller enthält eine Reihe verschiedener differenzierter und spezialisierter Zelltypen, und die Probleme ihrer Differenzierung gehören zu den Hauptanliegen der Entwicklungsphysiologie:
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Welche Mechanismen liegen einer differentiellen Genaktivierung zugrunde? Welche Rolle spielen dabei extrazelluläre und intrazelluläre Faktoren?
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Auf welcher Ebene (Transkription, mRNS-Processing, Gene splicing, Translation) erfolgt die Kontrolle?
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Wie lagern sich die Zellen zu Geweben zusammen? Wie kooperieren Zellen unterschiedlicher Herkunft miteinander?
Es gibt zahlreiche Möglichkeiten, these Fragen, zumin-dest ansatzweise, zu beantworten. In diesem Kapitel werden wir uns mit der Entwicklung von nur drei Typen spezialisierter Zellen befassen: Erythrozyten, Skelettmuskelzellen und Neuronen.
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Literatur
Augusti-Tocco, G., Sato, G.: Establishment of functional clonal lines of neurones from mouse neuroblastoma. Proc. Natl. Acad. Sci.USA 64, 311 (1969)
Bock, E.: Nervous system specific proteins. J. Neuro-chem. 30, 7(1978)
Buckingham, M.E., Caput, D., Cohen, A., Whalen, R.G., Gros, F.: The synthesis and stability of cytoplasmic messenger RNA during myoblast differentiation in culture. Proc. Natl. Acad. Sci. USA 71, 1466(1974)
Buckingham, M.E., Cohen, A., Gros, F.: Cytoplasmic distribution of pulse-labelled poly(A)-containing RNA, particularly 26 S RNA, during myoblast growth and differentiation. J. Mol. Biol. 103, 611 (1976)
Buckingham, M.E., Whalen, R.G., Gros, F.: Messenger ribonucleic acid metabolism during myogenesis. Biochem. Soc. Trans. 5, 474 (1977)
Bunge, R., Johnson, M., Ross, C.D.: Nature and nurture in development of the autonomic neuron. Science 199, 1409(1978)
Chaffee, J.K., Schachner, M.: NS-7 (nervous system antigen-7): A cell surface antigen of mature brain, kidney, and spermatozoa shared by embryonal tissues and transformed cells. Dev. Biol. 62, 185 (1978)
Chen, L.B.: Alteration in cell surface LETS protein during myogenesis. Cell 10, 393 (1977)
Diamond, J., Cooper, E., Turner, C., MacIntyre, L.: Trophic regulation of nerve sprouting. Science 193, 371(1976)
Dube, S.K., Gaedicke, G., Kluge, N., Weimann, B.J., Melderis, H., Steinheider, G., Grozier, T., Beckmann, H., Ostertag, W.: Hemoglobin-synthesizing mouse and human erythroleukemic cell lines as model systems for the study of differentiation and control of gene expression. In: Differentiation and control of malignancy of tumor cells. Nakahara, W., Ono, T., Sugrmura, T., Sugano, H. (eds.). Tokyo: University of Tokyo Press 1974
Eisen, H., Nasi, S., Georgopoulos, C.P., Arndt-Jovin, D., Ostertag, W.: Surface changes in differentiating friend erythroleukemic cells in culture. Cell 10, 689(1977)
Eisen, H., Keppel-Ballivet, F., Georgopoulos, C.P., Sassa, S., Granick, J., Pragneil, I., Ostertag, W.: Biochemical and genetic analysis of erythroid differentiation in friend virus-transformed murine erythroleukemic cells. Cold Spring Harbor Laboratory 1978
Fields, K.J., Brockes, J.P., Mirsky, R., Wendon, M.B.: Cell surface markers for distinguishing different types of rat dorsal root ganglion cells in culture. Cell 14, 43 (1978)
Furshpan, E.J., MacLeish, P.R., O’Lague, P.H., Potter, D.D.: Chemical transmission between rat sympathetic neurons and cardiac myocytes developing in microcultures: Evidence for cholinergic, adrenergic, and dual-function neurons. Proc. Natl. Acad. Sci. USA 73, 4225(1976)
Hamprecht, B.: Cell cultures as model systems for studying the biochemistry of differentiated functions of nerve cells. In: Colloquium der Gesellschaft für Biologische Chemie. Jaenicke, L. (ed.), S. 391–423. Berlin, Heidelberg, New York: Springer 1974
Harrison, P.R.: Analysis of erythropoesis at the molecular level. Nature (London) 262, 353 (1976)
Keppel, F., Allet, B., Eisen, H.: Appearance of a chromatine protein during the erythroid differentiation of Friend virus-transformed cells. Proc. Natl. Acad. Sci. USA 74, 653 (1977)
Klee, W.A., Nirenberg, M.: A neuroblastoma x glioma hybrid cell line with morphine receptors. Proc. Natl. Acad. Sci. USA 71, 3474 (1974)
Konigsberg, I.R.: Clonal analysis of myogenesis. Science 140, 1273(1963)
Lampert, A., Nirenberg, M., Klee, W.A.: Tolerance and dependence evoked by an endogenous opiate peptide. Proc. Natl. Acad. Sci. USA 73, 3165 (1976)
Letourneau, P.C.: Possible roles for cell-to-substratum adhesion in neuronal morphogenesis. Dev. Biol. 44, 77 (1975)
Marks, P.A., Rifkind, R.A.: Erythroleukemic differentiation. Annu. Rev. Biochem. 47, 419 (1978)
Minna, J., Nelson, P., Peacock, J., Glazer, D., Nirenberg, M.: Genes for neuronal properties expressed in neuroblastoma x glioma cell hybrids. Proc. Natl. Acad. Sci. USA 68, 234 (1976)
Nelson, P.G., Christian, C.N., Daniels, MP., Henkart, M., Bullock, P., Mullinax, D., Nirenberg, M.: Formation of synapses between cells of a neuroblastoma x glioma hybrid clone and mouse myotubes. Brain Res. 174, 245(1978)
Patterson, P.H., Potter, D.D., Fushpan, E.J.: The chemical differentiation of nerve cells. Sci. Am. Juli 1978, S. 38
Puro, D.G., Nirenberg, M.: On the specificity of synapse formation. Proc. Natl. Acad. Sci. USA 73, 3544(1976)
Rees, R.P.: The morphology of interneuronal synap-togenesis: a review. Fed. Proc. 37, 2000 (1978)
Sassa, S., Granick, J.L., Eisen, H., Ostertag, W.: Regulation of heme biosynthesis in mouse Friend virus-transformed cells in culture. In: In vitro aspects of erythropoiesis. Murphy, M.J., Jr. (ed.). New York, Heidelberg, Berlin: Springer 1978
Schachner, M.: NS-1 (nervous system antigen-1), a glial-cell-specific antigenic component of the surface membrane. Proc. Natl. Acad. Sci. USA 71, 1795(1974)
Schachner, M., Worthham, K.A., Carter, L.D., Chaffee, J.K.: NS4 (nervous system antigen-4), a cell surface antigen of developing and adult mouse brain and sperm. Dev. Biol. 44, 313 (1975)
Schubert, D., Heinemann, S., Carlisle, W., Tarikas, H., Kimes, B., Patrick, J., Steinbach, J.H., Culp. W., Brandt. B.L.: Clonal cell lines from the rat central nervous system. Nature (London) 249, 224 (1974)
Scordilis, S.P., Adelstein, R.S.: Myoblast myosin phosphorylation is a prerequisite for actin-activa-tion. Nature (London) 268, 558 (1977)
Solter, D., Schachner, M.: Brain and sperm cell surface antigen (NS-4) on preimplantation mouse embryos. Dev. Biol. 52. 98 (1976)
Yaffee, D.: Retention of differentiation potentialities during prolonged cultivation of myogenic cells. Proc. Natl. Acad. Sci. USA 61, 477 (1968)
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von Sengbusch, P. (1979). Entwicklung spezialisierter Zellen. In: Molekular- und Zellbiologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67358-0_65
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