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Autologous Bone Marrow Transplantation in Relapsed Adult Acute Leukemia

  • K. A. Dicke
  • A. R. Zander
  • G. Spitzer
  • D. S. Verma
  • L. Peters
  • L. Vellekoop
  • S. Thomson
  • D. Stewart
  • K. B. McCredie
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 25)

Abstract

From March, 1976 to February, 1979, 28 cases of adult acute leukemia of which 24 were evaluable were treated in irreversible relapse with high dose chemotherapy (piperazinedione) and supra-lethal total body irradiation (TBI) in conjunction with autologous bone marrow transplantation (ABMT). The marrow cells grafted were collected and stored in liquid nitrogen at the time of remission. In 12 patients the marrow cells were fractionated using discontinuous albumin gradients in an attempt to separate normal cells from residual leukemic cells. Twelve patients achieved complete remission (CR); in 9 additional patients signs of engraftment were evident but death occurred before achievement of CR. Seven of 12 AML patients, which were treated with bone marrow transplantation as first treatment of their relapse, achieved CR. Four of 5 patients with ALL, whose bone marrows were collected during first remission, reached CR. The median CR duration was 4+ months and the median survival of the patients reaching CR was 6+ months. Autologous bone marrow transplantation offers a good chance of CR (66%), when marrow is collected during first remission and used as first treatment for AML in third relapse and ALL in second relapse.

Keywords

Complete Remission Acute Lymphoblastic Leukemia Bone Marrow Transplantation Total Body Irradiation Autologous Bone Marrow Transplantation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • K. A. Dicke
  • A. R. Zander
  • G. Spitzer
  • D. S. Verma
  • L. Peters
  • L. Vellekoop
  • S. Thomson
  • D. Stewart
  • K. B. McCredie

There are no affiliations available

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