Local Factors Contributing to the Pathogenesis of Atherosclerosis

  • W. E. Stehbens


Atherosclerosis is an ubiquitous degenerative disease of blood vessels in man and many lower animals, and its severity varies from species to species and from individual to individual. However, quite apart from the species and individual susceptibility, it has long been recognized that local tissue factors play a role in the pathogenesis of this disease (1). Many authors speak glibly of hypothetic injury to the vessel wall, but the only site in the vascular system that could conceivably be regarded as being exposed to any form of injury during physiologic flow conditions would be the lines of contact on the opposing surfaces of cardiac valve cups. As hemodynamic factors are generally regarded as being important in the localization of the lesions, hemodynamics may well be the local factor responsible for the topographic distribution of atherosclerosis.


Arteriovenous Fistula Topographic Distribution Hemodynamic Stress Hemodynamic Factor Lateral Angle 
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© Springer-Verlag Berlin Heidelberg 1979

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  • W. E. Stehbens

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