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Studies on Experimental Ischemia in Mongolian Gerbils

  • I. Klatzo
  • M. Spatz

Abstract

Recent years have brought remarkable progress in understanding pathophysiologic mechanisms operative in cerebral ischemia. This progress can be attributed in large degree to the development of sophisticated methods for the evaluation of various parameters of ischemic injury, as well as to the opening of new areas in biochemistry that are especially pertinent to an understanding of the ischemic process. Also, of considerable significance has become the availability of the Mongolian gerbil model that allows rapid collecting of statistically well-documented data pertaining to many parameters of experimentation. The main advantage of the Mongolian gerbil model is based on the fact that, due to frequent anomalies of the circulus of Willis in approximately 30% of the animals, a simple occlusion of the common carotid artery in the neck produces ischemia in the ipsilateral hemisphere.

Keywords

Cerebral Ischemia Ischemic Injury Brain Edema Ischemic Insult Mongolian Gerbil 
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References

  1. 1.
    Aveldano, M.I., Bazan, N.G.: Rapid production of diacylglycerols enriched in arachidonate and stearate during early brain ischemia. J. Neurochem., 25, 919 (1975)PubMedCrossRefGoogle Scholar
  2. 2.
    Bazan, N.G.: Changes in free fatty acids of brain by drug-induced convulsions, electroshock and anesthesia. J. Neurochem., 18, 1379 (1971)PubMedCrossRefGoogle Scholar
  3. 3.
    Berson, F.G., Spatz, M., Klatzo, I.: Effect of oxygen saturation and CO2 on brain uptake of glucose analogues in rabbits. Stroke 6, 691 (1975)PubMedCrossRefGoogle Scholar
  4. 4.
    Bubis, J.J., Fujimoto, T., Ito, U., Mrsulja, B.J., Spatz, M., Klatzo, I.: Experimental cerebral ischemia in Mongolian gerbils. V. Ultrastructural changes in H3 sector of the hippocampus. Acta Neuropathol. 36, 285 (1976)PubMedCrossRefGoogle Scholar
  5. 5.
    Fujimoto, T., Walker, J.T., Jr., Spatz, M., Klatzo, I.: Pathophysiologic aspects of ischemic edema. In: Dynamics of brain edema, Pappius, H.M., Feindel, W. (eds.), p. 171. Berlin, Heidelberg, New York: Springer 1976Google Scholar
  6. 6.
    Galli, C., Spagnuolo, C.: The release of brain fatty acids during ischemia in essential fatty acid-deficient rats. J. Neurochem. 26, 401, (1976)PubMedCrossRefGoogle Scholar
  7. 7.
    Hervonen, H., Steinwall, O., Klatzo, I.: Permeability of the blood-brain barrier (BBB) to norepinephrine (NE) in experimental cerebral ischemia. In preparationGoogle Scholar
  8. 8.
    Ito, U., Spatz, M., Walker, J.T., Jr., Klatzo, I.: Experimental cerebral ischemia in Mongolian gerbils. I. Light microscopic observations. Acta Neuropathol. 32, 209 (1975)PubMedCrossRefGoogle Scholar
  9. 9.
    Ito, U., Go, K.G., Walker, J.T., Jr., Spatz, M., Klatzo, I.: Experimental cerebral ischemia in Mongolian gerbils. III. Behavior of the blood-brain barrier. Acta Neuropathol. 34, 1 (1976)PubMedCrossRefGoogle Scholar
  10. 10.
    Klatzo, I.: Pathophysiologic aspects of cerebral ischemia. In: The nervous system, Tower, D.B. (ed.), Vol. 1: The basic neurosciences, p. 313. New York: Raven Press 1975Google Scholar
  11. 11.
    Lust, W.D., Mrsulja, B.B., Mrsulja, B.J., Passonneau, J.V., Klatzo, I.: Putative neurotransmitters and cyclic nucleotides in prolonged ischemia of cerebral cortex. Brain Res. 98, 394 (1975)PubMedCrossRefGoogle Scholar
  12. 12.
    Micic, D., Micic, J., Swink, M.E., Spatz, M.: The anoxic effect on 2-Deoxy-D-(3H)-glucose uptake in isolated cerebral capillaries. Proc. Soc. Exp. Biol. Med., 158, 20 (1978)Google Scholar
  13. 13.
    Mrsulja, B.B., Mrsulja, B.J., Ito, U., Walker, J.T., Jr., Spatz, M., Klatzo, I.: Experimental cerebral ischemia in Mongolian gerbils. II. Changes in carbohydrates. Acta Neuropathol. 33, 91 (1975a)PubMedCrossRefGoogle Scholar
  14. 14.
    Mrsulja, B.B., Mrsulja, B.J., Spatz, M., Klatzo, I.: Action of cerebral ischemia on decreased levels of 3-metoxy-4-hydroxy-phenylethylglycol sulfate, homovanillic acid and 5-hydroxy-indoleacetic acid produced by pargyline. Brain Res. 98, 388 (1975b)PubMedCrossRefGoogle Scholar
  15. 15.
    Mrsulja, B.B., Lust, W.D., Mrsulja, B.J., Passonneau, J.V., Klatzo, I.: Post-ischemic changes in certain metabolites following prolonged ischemia in the gerbil cerebral cortex. J. Neurochem. 26, 1099 (1976a)CrossRefGoogle Scholar
  16. 16.
    Mrsulja, B.B., Mrsulja, B.J., Spatz, M., Ito, U., Walker, J.T., Jr., Klatzo, I.: Experimental cerebral ischemia in Mongolian gerbils. IV. Behavior of biogenic amines. Acta Neuropathol. 36, 1 (1976b)PubMedCrossRefGoogle Scholar
  17. 17.
    Mrsulja, B.B., Mrsulja, B.J., Spatz, M., Klatzo, I.: Catecholamines in brain ischemia-effects of α-methyl-p-tyrosine and pargyline. Brain Res. 104, 373 (1976c)PubMedCrossRefGoogle Scholar
  18. 18.
    Mrsulja, B.B., Lust, W.D., Mrsulja, B.J., Passonneau, J.V., Klatzo, I.: Brain glycogen following experimental cerebral ischemia in gerbils (Meriones unguiculatus). Experientia 32, 732 (1976d)CrossRefGoogle Scholar
  19. 19.
    Mrsulja, B.B., Mrsulja, B.J., Spatz, M., Klatzo, I.: Monoamines in cerebral ischemia in relation to brain edema. In: Dynamics of brain edema, Pappius, H.M., Feindel, W. (eds.), p. 187, Berlin, Heidelberg, New York: Springer 1976eGoogle Scholar
  20. 20.
    Mrsulja, B.B., Lust, W.D., Mrsulja, B.J., Passonneau, J.V.: Effect of repeated cerebral ischemia on metabolites and metabolic rate in gerbil cortex. Brain Res. 119, 480 (1977)PubMedCrossRefGoogle Scholar
  21. 21.
    Mrsulja, B.B., Djuricic, B.M., Mrsulja, B.J., Rogac, S., M., Klatzo, I.: Brain microvessels II. Effects of ischemia and dihydroergotoxin on enzymic activities. In: Advances in neurology. Vol. 20: Pathology of cerebral microcirculation. Cervos-Navarro, J., Betz, E., Ebhardt, G., Ferszt, R., Wüllenweber, R. (eds.), p. 197. New York: Raven Press 1978Google Scholar
  22. 22.
    Nishimoto, K., Wolman, M., Spatz, M., Klatzo, I.: Pathophysiologic correlations in the blood-brain barrier (BBB) damage due to air embolism. In: Advances in neurology, Vol. 20. Pathology of cerebral microcirculation. Cervós-Navarro, J., Betz, E., Ebhardt, G., Ferszt, R., Wüllenweber, R. (eds.), p. 237. New York: Raven Press 1978Google Scholar
  23. 23.
    Nishimoto, K., Kakari, S., Pappius, H., Spatz, M., Walker, J.T., Jr., Klatzo, I.: Behavior of the blood-brain barrier (BBB) in cerebral ischemia. In: Pathophysiology of cerebral energy metabolism. Mrsulja, B.B., Rakić, Lj.M., Klatzo, I., Spatz, M. (eds.), p. 99. New York, London: Plenum Press 1979Google Scholar
  24. 24.
    Nissl, F.: Über die Veränderungen der Ganglienzellen am Facialiskern des Kaninchens nach Ausreissung der Nerven. Allg. Z. Psychiatr. 48, 197 (1892)Google Scholar
  25. 25.
    Paulson, O.B., Herz, M.M., Bolwig, T.G., Lassen, N.A.: Filtration and diffusion of water across the blood-brain barrier in man. Microvasc. Res. 13, 113 (1977)PubMedCrossRefGoogle Scholar
  26. 26.
    Raichle, M.E., Eichling, J.O., Grubb, R.L., Jr., Hartman, B.K.: Central noradrenergic regulation of brain microcirculation. In: Dynamics of brain edema. Pappius, H.M., Feindel, W. (eds.), p. 11. Berlin, Heidelberg, New York: Springer 1976Google Scholar
  27. 27.
    Klatzo, I., Smialek, M., Hervonen, H., Steinwall, O., Spatz, M.: Post-ischemic changes and application of some therapeutic measures to influence the clinical course of cerebral ischemia. In: Proc. Int. Symp. on Postresuscitation Pathology of the Brain, Moscow 1978. In pressGoogle Scholar
  28. 28.
    Spatz, M., Go, G.K., Klatzo, I.: The effect of ischemia on the brain uptake of 14C-glucose analogues and 14C sucrose. In: Pathology of cerebral microcirculation. Cervós-Navarro, J. (ed.), p. 361. Berlin, New York: Walter de Gruyter Publ. 1974Google Scholar
  29. 29.
    Spatz, M., Fujimoto, T., Go, G.K.: Transport studies in ischemic cerebral edema. In: Dynamics of brain edema, Pappius, H.M., Feindel, W. (eds.), p. 181. Berlin, Heidelberg, New York: Springer (1976)Google Scholar
  30. 30.
    Spatz, M., Mrsulja, B.B., Micic, D., Mrsulja, B.J., Klatzo, I.: Ischemic and post-ischemic effects on 2-Deoxy-D (3H) glucose uptake in cerebral capillaries. Brain Res. 120, 141 (1977)PubMedCrossRefGoogle Scholar
  31. 31.
    Spatz, M., Micic, D., Fujimoto, T., Mrsulja, B.B., Klatzo, I.: Transport phenomena in cerebral ischemia. In: Pathophysiology of cerebral energy metabolism. Mrsulja, B.B., Rakić, Lj.M., Klatzo, I., Spatz, M. (eds.), p. 143. New York, London: Plenum Press 1979Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1979

Authors and Affiliations

  • I. Klatzo
  • M. Spatz

There are no affiliations available

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