Skip to main content

Hydrophobic Polymers as Materials for Interfacing with Blood

  • Chapter
Assisted Circulation

Abstract

This article is concerned with hydrophobic polymers and their application as blood-contacting surfaces. A recent review of this topic by the author [11] includes literature up to early 1976. Consequently the emphasis in this review, after a brief introductory and definition section, will be on the most recent developments.

Supported by Medical Research Council of Canada and Ontario Heart Foundation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Andrews, E. H.: Fatigue in polymers. In: Testing of polymers. Brown, W. E. (ed.), pp. 237–296. New York: Interscience 1969

    Google Scholar 

  2. Baier, R. E.: Surface properties influencing biological adhesion. In: Adhesion in biological systems. Manly, R. S. (ed.), pp. 15–48. New York: Academic Press, 1970

    Google Scholar 

  3. Baier, R. E.: The organization of blood components near interfaces. Ann. N.Y. Acad. Sci. 283, 17–36 (1977)

    Article  CAS  Google Scholar 

  4. Baier, R. E., Dutton, R. C.: Initial events in interactions of blood with a foreign surface. J. Biomed. Mater. Res. 3, 191–206 (1969)

    Article  PubMed  CAS  Google Scholar 

  5. Baumgartner, H. R., Muggli, R., Tschopp, T. B., Turitto, V. T.: Platelet adhesion, release and aggregation in flowing blood: effects of surface properties and platelet function. Thromb. Haemo-stas. 35, 124–138 (1976)

    CAS  Google Scholar 

  6. Bernstein, E. F.: Certain aspects of blood interfacial phenomena — red blood cells. Fed. Proc. 30, 1510–1515 (1971)

    PubMed  CAS  Google Scholar 

  7. Blackshear, P. L.: Hemolysis at prosthetic surfaces. In: The chemistry of biosurfaces. Hair, M. L. (ed.), Vol. II, pp. 523–562. New York: Marcel Dekker 1972

    Google Scholar 

  8. Boretos, J. W., Detmer, D. E., Donachy, H. J.: Segmented polyurethanl II. Two years experience. J. Biomed. Mater. Res. 5, 378–388 (1971)

    Google Scholar 

  9. Boretos, J. W., Pierce, W. S., Baier, R. E., Leroy, A. F., Donachy, H. J.: Surface and bulk characteristics of a polyether urethane for artificial hearts. J. Biomed. Mater. Res. 9, 327–340 (1975)

    Article  PubMed  CAS  Google Scholar 

  10. Braley, S.: The silicones as subdermal engineering materials. Ann. N.Y. Acad. Sci. 146, 148–157 (1968)

    Article  PubMed  CAS  Google Scholar 

  11. Brash, J. L.: Hydrophobic polymer surfaces and their interactions with blood. Ann. N.Y. Acad. Sci. 283, 356–371 (1977)

    Article  CAS  Google Scholar 

  12. Brash, J. L., Davidson, V. J.: Adsorption on glass and polyethylene from solutions of fibrinogen and albumin. Thromb. Res. 9, 249–259 (1976)

    Article  PubMed  CAS  Google Scholar 

  13. Brash, J. L., Lyman, D. J.: Adsorption of plasma proteins in solution to uncharged, hydrophobic polymer surfaces. J. Biomed. Mater. Res. 3, 175–189 (1969)

    Article  PubMed  CAS  Google Scholar 

  14. Brash, J. L., Samak, Q.: Dynamics of interactions between human albumin and polyethylene surface. Submitted for publication

    Google Scholar 

  15. Brash, J. L., Uniyal, S.: Adsorption of albumin and fibrinogen to polyethylene in presence of red cells. Trans. Am. Soc. Artif. Intern. Organs 22, 253–259 (1976)

    PubMed  CAS  Google Scholar 

  16. Brash, J. L., Uniyal, S.: Dependence of albumin-fibrinogen simple and competitive adsorption on surface properties of biomaterials. J. Polymer Sci. (in press)

    Google Scholar 

  17. Brash, J. L., Uniyal, S., Samak, Q.: Exchange of albumin adsorbed on polymer surfaces. Trans. Am. Soc. Artif. Intern. Organs 20, 69–76 (1974)

    Google Scholar 

  18. Brash, J. L., Brophy, J. M., Feuerstein, I. A.: Adhesion of platelets to artificial surfaces: effect of red cells. J. Biomed. Mater. Res. 10, 429–443 (1976)

    Article  PubMed  CAS  Google Scholar 

  19. Brynda, E., Houska, M., Pokorna, Z., Kalal, J.: Irreversible adsorption of human serum albumin onto a polyethylene film. J. Polymer Sci. (in press)

    Google Scholar 

  20. Butruille, Y. A., Leonard, E. F., Litwak, R. S.: Platelet-platelet interactions and nonadhesive encounters on biomaterials. Trans. Am. Soc. Artif. Intern. Organs 21, 609–614 (1975)

    PubMed  CAS  Google Scholar 

  21. Butruille, Y. A., Savitz, S. R., Leonard, E. F., Litwak, R. S.: Transient diffusion effects in the study of early platelet adhesion. J. Biomed. Mater. Res. 10, 145–160 (1976)

    Article  PubMed  CAS  Google Scholar 

  22. Cazenave, J.-P.: Personal communication

    Google Scholar 

  23. Chang, S. K., Hum, O. S., Moscarello, M. A., Neumann, A. W., Zingg, W., Leutheusser, M. J., Ruegsegger, B.: Platelet adhesion to solid surfaces, the effects of plasma proteins and substrate wettability. Med. Progr. Techn. (in press)

    Google Scholar 

  24. Cochrane, C. G., Revak, S. D., Wuepper, K. D.: Activation of Hageman factor in solid and fluid phases. J. Exp. Med. 138, 1564–1583 (1973)

    Article  PubMed  CAS  Google Scholar 

  25. Cuddihy, E. F., Moacanin, J., Roschke, E. J., Harrison, E. C.: In vivo degradation of silicone rubber poppets in prosthetic heart valves. J. Biomed. Mater. Res. 10, 471–481 (1976)

    Article  PubMed  CAS  Google Scholar 

  26. Cuypers, P. A., Hermens, W. T., Hemker, H. C.: Ellipsometric study of protein film on chromium. Ann. N.Y. Acad. Sci. 283, 77–85 (1977)

    Article  CAS  Google Scholar 

  27. Eberhart, R. C., Prokop, L. D., Wissenger, J., Wolkov, M. A.: Observation of albumin deposits on teflon surfaces. Trans. Am. Soc. Artif. Intern. Organs 23, 134–139 (1977)

    PubMed  CAS  Google Scholar 

  28. Feuerstein, I. A., Brophy, J. M., Brash, J. L.: Platelet transport and adhesion to reconstituted collagen and artificial surfaces. Trans. Am. Soc. Artif. Intern. Organs 21, 427–434 (1975)

    PubMed  CAS  Google Scholar 

  29. Fowkes, F. M.: Attractive forces at interfaces. Ind. Eng. Chem. 56 (12), 40–52 (1964)

    Article  CAS  Google Scholar 

  30. Fox, H. W., Zisman, W. A.: The spreading of liquids on low-energy surfaces. II. Modified tetra-fluorethylene polymers. J. Colloid Sci. 7, 109–121 (1952)

    Article  CAS  Google Scholar 

  31. Friedman, L. I., Liem, H., Grabowski, E. F., Leonard, E. F., McCord, C. W.: Inconsequentiality of surface properties for initial platelet adhesion. Trans. Am. Soc. Artif. Intern. Organs 16, 63–73 (1970)

    PubMed  CAS  Google Scholar 

  32. George, J. N.: Fibrinogen inhibits red cell adhesion to glass. J. Cell Physiol. 79, 547–562 (1972)

    Article  Google Scholar 

  33. Goldsmith, H. L.: Red œil motions and wall interaction in tube flow. Fed. Proc. 26, 1578–1588 (1971)

    Google Scholar 

  34. Grabowski, E. F., Didisheim, P., Lewis, J. C., Franta, J. T., Stropp, J. Q.: Platelet adhesion to foreign surfaces under controlled conditions of whole blood flow: human vs. rabbit, dog, calf, sheep, pig, macaque, and baboon. Trans. Am. Soc. Artif. Intern. Organs 23, 141–149 (1977)

    PubMed  CAS  Google Scholar 

  35. Horbett, T. A., Hoffman, A. S.: Bovine plasma protein adsorption onto radiation-grafted hydrogels based on hydroxyethyl methacrylate and N-vinylpyrrolidone. In: Applied chemistry at protein interfaces. Baier, R. E. (ed.), pp. 230–254. Washington D.C.: A.C.S. 1975

    Chapter  Google Scholar 

  36. Horbett, R. A., Weathersby, P. K., Hoffman, A. S.: The preferential adsorption of hemoglobin to polyethylene. J. Bioeng. 1, 61–78 (1977)

    PubMed  CAS  Google Scholar 

  37. Jamieson, G. A., Urban, C. L., Barber, A. J.: Enzymatic basis for platelet: collagen adhesion as the primary step in haemostasis. Nature New Biol. 234, 5–7 (1971)

    PubMed  CAS  Google Scholar 

  38. Kaeble, D. M.: Dispersion-polar surface tension properties of organic solids. J. Adhesion 2, 66–81 (1970)

    Article  Google Scholar 

  39. Keller, K. H.: Effect of fluid shear on mass transport in flowing blood. Fed. Proc. 30, 1591–1599 (1971)

    PubMed  CAS  Google Scholar 

  40. Kim, S. W., Wisniewski, S., Lee, E. S., Winn, M. L.: Role of protein and fatty acid adsorption on platelet adhesion and aggregation at the blood-polymer interface. J. Biomed. Mater. Res. Symp. 8, 23–31 (1977)

    Article  CAS  Google Scholar 

  41. Kochwa, S., Litwak, R. S., Rosenfield, R. E., Leonard, E. F.: Blood elements at foreign surfaces: a biochemical approach to the study of the adsorption of plasma proteins. Ann. N. Y. Acad. Sci. 283, 37–49 (1977a)

    Article  CAS  Google Scholar 

  42. Kochwa, S., Litwak, R. S., Rosenfield, R. E., Leonard, E. F.: Blood elements at foreign surfaces: in vitro evaluation of biomaterials in a spinning disc apparatus. Ann. N. Y. Acad. Sci. 283, 457–472 (1977b)

    Article  CAS  Google Scholar 

  43. Lampert, R. H., Williams, M. C.: Effect of surface materials on shear-induced hemolysis. J. Biomed. Mater. Res. 6, 499–532 (1972)

    Article  PubMed  CAS  Google Scholar 

  44. Lee, R. G., Kim, S. W.: Adsorption of proteins onto hydrophobic polymer surfaces: adsorption isotherms and kinetics. J. Biomed. Mater. Res. 8, 251–259 (1974a)

    Article  PubMed  CAS  Google Scholar 

  45. Lee, R. G., Kim, S. W.: The role of carbohydrate in platelet adhesion to foreign surfaces. J. Biomed. Mater. Res. 8, 393–398 (1974b)

    Article  PubMed  CAS  Google Scholar 

  46. Lee, R. G., Kim, S. W.: Cyclic AMP and platelet adhesion to silastic surfaces. Thromb. Res. 8, 111–114 (1976)

    Article  PubMed  CAS  Google Scholar 

  47. Lee, R. G., Adamson, C., Kim, S. W.: Competitive adsorption of plasma proteins onto polymer surfaces. Thromb. Res. 4, 485–490 (1974)

    Article  PubMed  CAS  Google Scholar 

  48. Liebert, R. C., Chartoff, R. P., Cosgrove, S. L., McCuskey, R. S.: Subcutaneous implants of polypropylene filaments. J. Biomed. Mater. Res. 10, 939–951 (1976)

    Article  PubMed  CAS  Google Scholar 

  49. Lindsay, R. M., Friesen, M., Cooper, J., Birek, A., Scott, K., Linton, A. L.: Platelet foreign surface interactions with oxygenator membranes. In: Artificial organs. Kenedi, R. M. et al. (eds.), pp. 248–262. London: Macmillan 1977

    Google Scholar 

  50. Lyklema, J., Norde, W.: Biopolymer adsorption with special reference to the serum albumin-polystyrene latex system. Croatica Chem. Acta 45, 67–84 (1973)

    CAS  Google Scholar 

  51. Lyman, D. J., Muir, W. M., Lee, I. J.: The effect of chemical structure and surface properties of polymers on the coagulation of blood. I. Surface free energy effects. Trans. Am. Soc. Artif. Intern. Organs 11, 301 (1965)

    PubMed  CAS  Google Scholar 

  52. Lyman, D. J., Klein, K. G., Brash, J. L., Fritzinger, B. K.: Interaction of platelets with polymer surfaces. I. Uncharged hydrophobic polymer surfaces. Thromb. Haemostas. 23, 120–128 (1970)

    CAS  Google Scholar 

  53. MacRitchie, F.: The adsorption of proteins at the solid-liquid interface. J. Colloid Interface Sci. 38, 484–488 (1972)

    Article  CAS  Google Scholar 

  54. McMillin, C. R., Walton, A. G.: A circular dichroism technique for the study of adsorbed protein structure. J. Colloid Interface Sci. 48, 345–349 (1974)

    Article  CAS  Google Scholar 

  55. Mohammad, S. F., Hardison, M. D., Chuang, H. Y. K., Mason, R. G.: Adhesion of human blood platelets to glass and polymer surfaces. II. Demonstration of the presence of a natural platelet adhesion inhibitor in plasma and serum. Haemostasis 5, 96–114 (1976)

    PubMed  CAS  Google Scholar 

  56. Mohandas, N., Hochmuth, R. M., Spaeth, E. E.: Adhesion of red cells to foreign surfaces in the presence of flow. J. Biomed. Mater. Res. 8, 119–136 (1974)

    Article  PubMed  CAS  Google Scholar 

  57. Morrissey, B. W.: The adsorption and conformation of plasma proteins: a physical approach. Ann. N.Y. Acad. Sci. 283, 50–64 (1977)

    Article  CAS  Google Scholar 

  58. Morrissey, B. W., Fenstermaker, C. A.: Conformation of adsorbed γ-globulin and β-lactoglobulin. Effect of surface concentration. Trans. Am. Soc. Artif. Intern. Organs 22, 278–283 (1976)

    PubMed  CAS  Google Scholar 

  59. Morrissey, B. W., Stromberg, R. R.: The conformation of adsorbed blood proteins by infrared bound fraction measurements. J. Colloid Interface Sci. 46, 152–164 (1974)

    Article  CAS  Google Scholar 

  60. Mustard, J. F., Kinlough-Rathbone, R. L., Packham, M. A.: Recent status of research in the pathogenesis of thrombosis. Thromb. Haemostas. Suppl. 59, 157–188 (1974)

    Google Scholar 

  61. Neumann, A. W., Hope, C. J., Ward, C. A., Herbert, M. A., Dunn, G. W., Zingg, W.: The role of surface thermodynamics in thromboresistance of biomaterials. J. Biomed. Mater. Res. 9, 127–142 (1975)

    Article  PubMed  CAS  Google Scholar 

  62. Norde, W.: Proteins at interfaces. Thesis, Agric. Univ., Wageningen, Netherlands (1976)

    Google Scholar 

  63. Nyilas, E., Chiu, T.-H., Herzlinger, G. A.: Thermodynamics of native protein/foreign surface interactions. I. Calorimetry of the human γ-globulin/glass system. Trans. Am. Soc. Artif. Intern. Organs 20, 480–490 (1974)

    PubMed  Google Scholar 

  64. Nyilas, E., Morton, W. A., Cumming, R. D., Lederman, D. M., Chiu, T.-H.: Effects of polymer surface molecular structure and force-field characteristics on blood interfacial phenomena. J. Biomed. Mater. Res. Symp. 8, 51–68 (1977)

    Article  Google Scholar 

  65. Oreskes, I., Singer, J. M.: The mechanism of particulate carrier reactions. Adsorption of human γ-globulin to polystyrene latex particles. J. Immunol. 86, 338–344 (1961)

    PubMed  CAS  Google Scholar 

  66. Packham, M. A., Evans, G., Glynn, M. F., Mustard, J. F.: The effect of plasma proteins on the interaction of platelets with glass surfaces. J. Lab. Clin. Med. 73, 686–697 (1969)

    PubMed  CAS  Google Scholar 

  67. Petschek, H., Adamis, D., Kantrowitz, A. R.: Stagnation flow thrombus formation. Trans. Am. Soc. Artif. Intern. Organs 14, 256–259 (1968)

    PubMed  CAS  Google Scholar 

  68. Picha, G. J., Gibbons, D. F., Auerbach, R.: Effect of polyurethane morphology on blood coagulation. J. Bioeng. (in press)

    Google Scholar 

  69. Ratner, B. D., Hoffman, A. S., Hanson, S. R., Harker, L. A., Whiffen, J. D.: Blood compatibility -water content relationships for radiation-grafted hydrogels. J. Polymer Sci. (in press)

    Google Scholar 

  70. Roohk, H. V., Nakamura, M., Hill, R. L., Hung, E. K., Bartlett, R. H.: A thrombogenic index for blood contact materials. Trans. Am. Soc. Artif. Intern. Organs 23, 152–160 (1977)

    PubMed  CAS  Google Scholar 

  71. Salzman, E. W., Lindon, J., Brier, D., Merrill, E. W.: Surfaceinduced platelet adhesion, aggregation, and release. Ann. N. Y. Acad. Sci. 283, 114–127 (1977)

    Article  CAS  Google Scholar 

  72. Stewart, G. J., Lynch, P. R., Reichle, F. A., Ritchie, W. G. M., Smith, A., Schaub, R. G.: The adhesion of leukocytes, erythrocytes, and noncellular material to the luminal surface of natural and artificial blood vessels in vivo. Ann. N. Y. Acad. Sci. 283, 179–207 (1977)

    Article  CAS  Google Scholar 

  73. Swanson, J. W., Lebeau, J. E.: The effect of implantation on the physical properties of silicone rubber. J. Biomed. Mater. Res. 8, 357–367 (1974).

    Article  PubMed  CAS  Google Scholar 

  74. Szycher, M., Poirier, V., Keiser, J.: Selection of materials for ventricular assist pump development and fabrication. Trans. Am. Soc. Artif. Intern. Organs 23, 116–124 (1977)

    PubMed  CAS  Google Scholar 

  75. Turitto, V. T., Benis, A. M., Leonard, E. F.: Platelet diffusion in flowing blood. Ind. Eng. Chem. Fundam. 11, 216–232 (1972)

    Article  CAS  Google Scholar 

  76. Vroman, L., Adams, A. L.: Identification of rapid changes at plasma-solid interfaces. J. Biomed. Mater. Res. 3, 43–67 (1969)

    Article  PubMed  CAS  Google Scholar 

  77. Vroman, L., Adams, A. L., Klings, M., Fischer, G.: Fibrinogen, globulins, albumin and plasma at interfaces. In: Applied chemistry at protein interfaces. Baier, R. E. (ed.), pp. 255–289. Washington DC: ACS 1975

    Chapter  Google Scholar 

  78. Vroman, L., Adams, A. L., Klings, M., Fischer, G. C., Munoz, P. C., Solensky, R. P.: Reactions of formed elements of blood with plasma proteins at interfaces. Ann. N.Y. Acad. Sci. 283, 65–76 (1977)

    Article  CAS  Google Scholar 

  79. Wainwright, S. A., Biggs, W. D., Currey, J. D., Gosline, J. M.: Mechanical design in organisms, p. 1/74. London: Edward Arnold 1976

    Google Scholar 

  80. Watkins, R. W., Robertson, C. R.: A total internal reflection technique for the examination of protein adsorption. J. Biomed. Mater. Res. 11, 915–938 (1977)

    Article  PubMed  CAS  Google Scholar 

  81. Waugh, D. F., Anthony, L. J., Ng, H.: The interaction of thrombin with borosilicate glass surfaces. J. Biomed. Mater. Res. 9, 511–536 (1975)

    Article  PubMed  CAS  Google Scholar 

  82. Weiss, L., Blumenson, L. E.: Dynamic adhesion and separation of cells in vitro. II. Interactions of cells with hydrophilic and hydrophobic surfaces. J. Cell Physiol. 70, 23–32 (1967)

    Article  PubMed  CAS  Google Scholar 

  83. Whicher, S. J., Brash, J. L.: Platelet-foreign surface interactions: release of granule constituents from adherent platelets. J. Biomed. Mater. Res. (in press)

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1979 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Brash, J.L. (1979). Hydrophobic Polymers as Materials for Interfacing with Blood. In: Unger, F. (eds) Assisted Circulation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67268-2_49

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-67268-2_49

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-67270-5

  • Online ISBN: 978-3-642-67268-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics