Drug Actions in Rats with Arteriosclerosis Induced by Toxic Doses of Vitamin D2

  • Y. M. Baraka
  • H. Bekemeier
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 2)


The vascular response of isolated perfused hind legs from normal and arteriosclerotic rats to noradrenaline, ATP, PGF2α and vasopressin was determined. The increase of perfusion pressure to noradrenaline and ATP was reduced and that to PGF2α and vasopressin was enhanced in arteriosclerotic rats in comparison to normal animals. The results indicate that the reactivity of the vascular smooth muscle of isolated hind legs of arterioslerotic rats is not only quantitatively but also qualitatively different in comparison with normal rats.

Key words

Vasoactive compounds Arteriosclerotic blood vessels Perfusion pressure Circulation Rat 


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  1. Baraka, Y. M., Bekemeier, H., Giessler, A. J., Rashid, R.: Prostataglandin release from the perfused isolated hind legs in normal and arteriosclerotic rats. Acta biol. med. germ. 37, 851–853 (1978)PubMedGoogle Scholar
  2. Clineschmidt, B. V., Geller, R. G., Govier, W. C., Sjoerdsma, A.: Reactivity to Norepinephrine and Nature of the Alpha Adrenergic Receptor in Vascular Smooth Muscle of a Genetically Hypertensive Rat. Europ. J. Pharmacol. 10, 45–50 (1970)CrossRefGoogle Scholar
  3. Ellis, E., Hutchins, P.: Cardiovascular responses to prostaglandin F2α in spontaneously hypertensive rats. Prostaglandins 7, 345–353 (1974)PubMedCrossRefGoogle Scholar
  4. Grollman, A., Krishnamurty, V. S. P.: Contractile response of the aorta of the normotensive and acute and chronic hypertensive rat. Arch. Internat. Pharmacodyn. Ther. 203, 376–387 (1973)Google Scholar
  5. Gryglewski, H. J.: The possible role of thromboxane A2 and prostacyclin (PGX) in circulation. Lecture at the Sec. Internat. Symp. on Prostaglandins, Halle (Saale), September 19–21, 1977Google Scholar
  6. Haeusler, G., Haefely, W.: Pre- and Postjunctional Supersensitivity of the Mesenteric Artery Preparation from Normotensive and Hypertensive Rats. Arch. Pharmakol. 266, 18–33 (1970)Google Scholar
  7. Hansen, R., Bohr, D. F.: Hypertension, Transmural Pressure, and Vascular Smooth Muscle Response in Rats. Circulat. Res. 36, 590–598 (1975)PubMedGoogle Scholar
  8. Harris, G. S.: ATP Vascular Reactivity after Chronic Adrenalectomy. Europ. J. Pharmacol. 16, 391–392 (1971)CrossRefGoogle Scholar
  9. Holloway, E. T., Bohr, D. F.: Reactivity of Vascular Smooth Muscle in Hypertensive Rats. Circulat. Res. 33, 678–686 (1973)PubMedGoogle Scholar
  10. Hrdina, P. D.: Role of CA2+ and Mg2+ in Contractile Effect of ATP on Isolated Perfused Renal Artery. Europ. J. Pharmacol. 12, 249–252 (1970)CrossRefGoogle Scholar
  11. Malik, K. U., McGiff, J. C.: In: Prostaglandins, Physiological, Pharmacological, and Pathological Aspects. Karim, S. M. M. (ed.), p. 201. Lancaster Engl.: MTP 1976Google Scholar
  12. Okamota, K., Hazama, F., Takeda, T., Tabei, R., Nosaka, S., Fukushima, M., Yamori, Y., Matsumoto, M., Haebara, H., Ichijima, K., Suszuki, Y.: Pharmocodynamic studies on the cardiovascular system of spontaneously hypersensitive rats. Jap. Circulat. J. 30, 987–1007 (1966)CrossRefGoogle Scholar
  13. Schömig, A., Lüth, B., Dietz, R., Gross, F.: Changes in vascular smooth muscle sensitivity to vasoconstrictor agents induced by corticosteroids, adrenalectomy and differing salt intake in rats. Clin. Sci. Molec. Med. 51, 615–635 (1976)Google Scholar
  14. Shibata, S., Kurahashi, K., Kuchii, M.: A possible etiology of contractility impairment of vascular smooth muscle from spontaneously hypertensive rats. J. Pharmacol. Exp. Ther. 185, 406–417 (1973)PubMedGoogle Scholar
  15. Sobel, H., Mondon, C. E., Straus, R.: Spontaneous and Stress-Induced Myocardial Infarction in Aged Atherosclerotic Dogs. Circulat. Res. 11, 971–981 (1962)PubMedGoogle Scholar
  16. Spector, S., Fleisch, T. H., Maling, H. M., Brodie, B. B.: Vascular Smooth Muscle Reactivity in Normotensive and Hypertensive Rats. Science 166, 1300 (1969)PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • Y. M. Baraka
    • 1
  • H. Bekemeier
    • 1
  1. 1.Section of PharmacyMartin-Luther-UniversityHalle (Saale)German Democratic Republic

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