Abstract
Studies of the pattern of DNA replication have been a useful approach for analysing the timing of DNA synthesis in relation to the cell cycle. The method of labelling chromosomes with a radioactive precursor (tritiated thymidine) was first introduced by Taylor et al. (1957), and has been used to study the chromosome complement of many organisms, including man (for a review see Passarge, 1970). One of the most important findings before the development of banding techniques was that the asynchrony of DNA replication within a chromosome group permitted the presumptive identification of a pair of homologues, based on a specific pattern of labelling. It was also evident in man that the Y chromosome in males and one of the X chromosomes in females were late-replicating in relation to the rest of the chromosome complement. Using similar methods, Low and Benirschke (1969) studied the late-replication pattern of the chromosome complement of Pan troglodytes and compared it with that of man. Although many chromosomes of man and chimpanzee showed a very similar morphology, Low and Benirschke (1969) found considerable differences in labelling pattern.
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Seuánez, H.N. (1979). Late DNA Replicating Patterns in the Chromosomes of Man and the Great Apes. In: The Phylogeny of Human Chromosomes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67260-6_17
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DOI: https://doi.org/10.1007/978-3-642-67260-6_17
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