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Verwertung der Energiespeicher und Energiegewinnung in der Postresorptionsphase

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Biochemie
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Zusammenfassung

Organspezifischer Substratfluß im „Hunger“und im „Fasten“

  • Im „Hunger“(kurzfristiger Nahrungsentzug) und im „Fasten“(langfristiger Nahrungsentzug) werden die polymeren Energiespeicher zu monomeren Substraten abgebaut, die dann von den einzelnen Organen zur Energiegewinnung herangezogen werden. Der Stoffwechsel ist in beiden Phasen qualitativ gleich, aber quantitativ deutlich verschieden. Die meisten Organe können Fettsäuren als Energiesubstrate verwerten, das ZNS und die Erythrocyten sind jedoch auf Glucose angewiesen. Daher muß der Organismus immer gleichzeitig Fettsäuren und Glucose bereitstellen.

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Literatur

Organspezifischer Substratfluß

  • Cahill, G. F., Morliss, E. B., Aoki, T. T.: Fat and nitrogen metabolism in fasting man. In: Adipose Tissue, Regulation and Functions (Jeanrenaud, B., Hepp, D., Eds.), p. 181. Stuttgart: Thieme; New York: Academic Press 1970.

    Google Scholar 

  • Owen, O. E., Reichard, G. A.: Fuels consumed by man. The interplay between carbohydrates and fatty acids. In: Progress in Biochemical Pharmacology (Paoletti, R., Ed.), Vol. 6, p. 177–213. Basel: Karger 1971.

    Google Scholar 

  • Krebs, H. A.: Some aspects of the regulation of fuel supply in omnivorous animals. Advanc. Enzyme Regulat. 10, 397–420 (1972).

    Article  CAS  Google Scholar 

  • Young, V. R., Scrimshaw, N. S.: The Physiology of Starvation. Sci. Amer. 225, (4), 14–21 (1971).

    Article  PubMed  CAS  Google Scholar 

  • McIlwain, H., Bachelard, H. S.: Biochemistry and the Central Nervous System, p. 8–31. London: Churchill-Livingstone 1971.

    Google Scholar 

  • Lin, E. C.: Glycerol utilization and its regulation in mammals. Ann. Rev. Biochem. 46, 765–795 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Fröberg, S., Carlson, L., Ekelund, L.: Local Lipid Stores and Exercise. Adv. Exp. Med. Biol. 11, 307–313 (1971).

    Google Scholar 

  • Hultman, E., Nilsson, L. H.: Liver Glycogen in Man. Effect of Different Diets and Muscular Exercise. Adv. Exp. Med. Biol. 11, 143–151 (1971).

    Google Scholar 

  • Hultman, E., Bergström, J., Roch-Norlund, A. E.: Glycogen Storage in Human Skeletal Muscle. Adv. Exp. Med. Biol. 11, 273–288 (1971).

    CAS  Google Scholar 

  • Saltin, B., Karlsson, J.: Muscle Glycogen Utilization During Work of Different Intensities. Adv. Exp. Med. Biol. 11, 289–299 (1971).

    CAS  Google Scholar 

  • Keul, J.: Myocardial Metabolism in Athletes. Adv. Exp. Med. Biol. 11, 447–455 (1971).

    CAS  Google Scholar 

Stoff wechselsteuerung durch Hormone

  • Sawin, C. T.: The Hormones. London: Churchill 1969.

    Google Scholar 

  • Unger, R. H.: Alpha- and Beta-cell Interrelationsships in Health and Disease. Metabolism 23, 581–593 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Himms-Hagen, J.: Effects of Catecholamines on Metabolism. In: Handbook of Experimental Pharmacology, Vol. 33, p. 363–462. Berlin-Heidelberg-New York: Springer 1972.

    Google Scholar 

  • Taunton, O. D., Stiefel, F. B., Greene, H. L., Herman, R. H.: Rapid Reciprocal Changes in Rat Hepatic Glycolytic Enzyme and Fructosediphosphatase Activities following Insulin and Glucagon Injection. J. biol. Chem. 249, 7228–7239 (1974).

    PubMed  CAS  Google Scholar 

  • Stiefel, F. B., Taunton, O. D., Greene, H. L., Herman, R. H.: Rapid Reciprocal Changes in Rat Tissue Enzyme Activities following Epinephrine Injection. J. biol. Chem. 249, 7240–7244 (1974).

    Google Scholar 

  • Thompson, E. B., Lippman, M. E.: Mechanism of Action of Glucocorticoids. Metabolism 23, 159 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Gerich, J. E., Lorenzi, M., Hane, S., Gustafson, G., Guillemin, R., Forsham, P. H.: Evidence for a Physiological Role of Pancreatic Glucagon in Human Glucose Homeostasis: Studies With Somatostatin. Metabolism 24, 175 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Unger, R. H.: Pancreatic Glucagon in Health and Disease. Advanc. intern. Med. 17, 265 (1971).

    CAS  Google Scholar 

  • Day, J. L.: The Metabolic Consequences of Adrenergic Blockade: a Review. Metabolism 24, 987–996 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Fain, J. N., Tolbert, M. E. M., Pointer, R. H., Butcher, F. R., Arnold, A.: Cyclic Nucleotides and Gluconeogenesis by Rat Liver Cells. Metabolism 24, 395 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Salomon, Y., Lin, M. C., Londos, C., Rendell, M., Rodbell, M.: The Hepatic Adenylate Cyclase System (GTP Activation). J. biol. Chem. 250, 4239–4245 (1975).

    PubMed  CAS  Google Scholar 

  • Pastan, I.: Cyclic AMP. Sci. Amer. 227 (8), 97 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Hardman, J. G., Robison, G. A., Sutherland, E. W.: Cyclic Nucleotides. Ann. Rev. Physiol. 33, 311–336 (1971).

    Article  CAS  Google Scholar 

  • Siegenthaler, W., Werning, C., Vetter, W.: Nebennierenrinde. In: Klinische Pathophysiologie, (W. Siegenthaler, Hrsg.), p. 335–366. Stuttgart: Thieme 1976.

    Google Scholar 

  • Burgus, R., Guillemin, R.: Hypothalamic releasing factors. Ann. Rev. Biochem. 39, 499 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Merimee, T. J., Rabin, D.: A survey of growth hormone secretion and action. Metabolism 22, 1235–1251 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Van Wyk, J. J., Underwood, L. E., Hintz, R. L., Clemmons, D. R., Voina, S. J., Weaver, R. P.: The Somatomedins: A family of insulinlike hormones under growth hormone control. Rec. Progr. Horm. Res. 30, 259 (1974).

    PubMed  Google Scholar 

  • Gelehrter, Th. D.: Mechanism of Hormonal Induction of Enzymes. Metabolism 22, 85 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Sutherland, E. W.: Zur Wirkungsweise der Hormone. Angew. Chem. 84, 1117 (1972).

    Article  Google Scholar 

  • Bühler, H. U., Da Prada, M., Haefely, W., Picotti, G. B.: Plasma Adrenalin, Noradrenalin and Dopamine in Man and Different Animal Species. J. Physiol. 276, 311–320 (1978).

    PubMed  Google Scholar 

  • Lüthold, B. E., Bühler, F. R., Da Prada, M.: Dynamik von Plasmacatecholaminen und β-Adrenoceptor-Funktionen. Schweiz. med. Wschr. 106, 1735–1738 (1976).

    Google Scholar 

  • von Euler, U. S.: Adrenal medullary secretion and its neural control. In: Neuroendocrinology, Vol. II (C. Martini, W. F. Ganong, Eds.) p. 283. New York-London: Academic Press 1967

    Google Scholar 

  • Pfeuffer, T., Helmreich, E.: Activation of Pigeon Erythrocyte Membrane Adenylate Cyclase by Guanylnucleotide Analogues and Separation of a Nucleotide Binding Protein. J. biol. Chem. 250, 867–876 (1975)

    PubMed  CAS  Google Scholar 

  • Levitzki, A.: The Role of GTP in the Activation of Adenylate Cyclase. Biochem. Biophys. Res. Commun. 74, 1154–1159 (1977).

    Article  PubMed  CAS  Google Scholar 

Energiespeicherabbau zu monomeren Substraten

  • Fischer, E. H., Heilmeyer, L., Haschke, R. H.: Phosphorylase and the Control of Glycogen Degradation. Curr. Top. Cell Regulat. 4, 211–251 (1971).

    CAS  Google Scholar 

  • Krebs, E. G.: Protein Kinases. Curr. Top. Cell Regulat. 5, 99–134 (1972).

    CAS  Google Scholar 

  • Hers, H. G., De Wulf, H., Stalmans, W.: The control of glycogen metabolism in the liver. FEBS Letters 12, 73–81 (1970).

    Article  PubMed  Google Scholar 

  • Jeanrenaud, B.: Adipose Tissue Dynamics and Regulation. Ergebn. Physiol. 60, 57–140 (1968).

    PubMed  CAS  Google Scholar 

  • London, D. R., Foley, T. H.: Evidence for the Release of Individual Aminoacids from the Resting Human Forearm. Nature 208, 588–589 (1965).

    Article  CAS  Google Scholar 

  • Ruderman, N. B., Berger, M.: The Formation of Glutamin and Alanine in Skeletal Muscle. J. biol. Chem. 249, 5500–5506 (1974).

    PubMed  CAS  Google Scholar 

  • Schimassek, H., Gerok, W.: Control of the Levels of Free Amino Acids in Plasma by the Liver. Biochem. Z. 343, 407–415 (1965).

    PubMed  CAS  Google Scholar 

  • Garber, A. J., Karl I.E., Kipnis, D.M.: Alanine and Glutamine Synthesis and Release from Skeletal Muscle. J. biol. Chem. 251, 826–835, 836–843, 844–850, 851–857 (1976).

    PubMed  CAS  Google Scholar 

  • Shimazu, T., Amakawa, A.: Regulation of glycogen metabolism in liver by the autonomic nervous system; possible mechanism of Phosphorylase activation by the splanchnic nerve. Biochem. Biophys. Acta 385, 242–256 (1975).

    PubMed  CAS  Google Scholar 

Energiegewinnung durch Abbau monomerer Substrate

  • Greville, G. D., Tubbs, P. K.: The Catabolism of Long-Chain Fatty Acids in Mammalian Tissues. Ess. Biochem. 4, 155–212 (1968).

    CAS  Google Scholar 

  • Masoro, E. J.: Physiological Chemistry of Lipids in Mammals. Philadelphia: Saunders 1968.

    Google Scholar 

  • Thomitzek, W. D.: Die Rolle des Carnitins im Intermediärstoffwechsel. Ergebn. Physiol. 62, 68–90 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Krebs, H. A., Williamson, D. H., Bates, M. N., Page, M. A., Hawkins, R. A.: The Role of Ketone Bodies in Caloric Homeostasis. Adv. Enzyme Regulat. 9, 387–409 (1971).

    Article  Google Scholar 

  • Felig, P.: Amino Acid Metabolism in Man. Ann. Rev. Biochem. 44, 933–955 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Schepartz, B.: Regulation of Amino Acid Metabolism in Mammals. Philadelphia: Saunders 1973.

    Google Scholar 

  • Krebs, H. A., Hems, R., Lund, P.: Some regulatory mechanisms in the synthesis of urea in mammalian liver. Adv. Enzyme Regulat. 11, 361–378 (1973).

    Article  CAS  Google Scholar 

  • Ratner, S.: Enzymes of Arginine and Urea Synthesis. Advanc. Enzymol. 39, 1–90 (1973).

    CAS  Google Scholar 

  • Lowenstein, J. M.: Ammonia Production in Muscle and Other Tissues: the Purine Nucleotide Cycle. Physiol. Rev. 52, 382–414 (1972).

    CAS  Google Scholar 

  • McGivan, J. D., Chappell, J. B.: On the metabolic function of glutamate dehydrogenase in rat liver. FEBS Letters 52, 1–7 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Sies, H., Summer, K. H., Bücher, Th.: A process requiring mitochondrial NADPH: urea formation from ammonia. FEBS Letters 54, 274 (1975).

    Article  PubMed  CAS  Google Scholar 

Bereitstellung monomerer Substrate aus anderen monomeren Vorläufern

  • Scrutton, M. C., Utter, M. F.: The regulation of glycolysis and gluconeogenesis in animal tissues. Ann. Rev. Biochem. 37, 249–302 (1968).

    Article  CAS  Google Scholar 

  • Exton, J.H.: Gluconeogenesis. Metabolism 21, 945–989 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Newsholme, E. A., Start, C.: Regulation in metabolism, p. 71–73, 121–124, 247–292, 315–323. London: Wiley 1973.

    Google Scholar 

  • Gumaa, K. A., Greenbaum, A. L., McLean, P.: Compartmentation in relation to metabolic control in liver. Ess. Biochem. 7, 39–86 (1971).

    CAS  Google Scholar 

  • Marliss, E., Aoki, T. T., Felig, P., Pozefsky, T., Cahill, G. F.: Hormones and Substrates in the Regulation of Gluconeogenesis in Fasting Man. Advanc. Enzyme Regulat. 8, 3–12 (1970).

    Article  CAS  Google Scholar 

  • Sasse, D., Katz, N., Jungermann, K.: Functional Heterogeneity of Rat Liver Parenchyma and of Isolated Hepatocytes. FEBS Letters 57, 83–88 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Krebs, H. A.: The Regulation of the Release of Ketone Bodies by the Liver. Advanc. Enzyme Regulat. 4, 339–353 (1966).

    Article  CAS  Google Scholar 

  • Felig, P., Wahren, J., Räf, L.: Evidence of Inter-Organ Amino-Acid Transport by Blood Cells in Humans. Proc. Nat. Acad. Sci. USA 70, 1775–1779 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Williamson, J. R.: Role of Anion Transport in the Regulation of Metabolism. In: Gluconeogenesis — Its Regulation in Mammalian Species (R. W. Hanson, M. A. Mehlman, Eds.) p. 165–220. New York: Wiley 1976.

    Google Scholar 

  • Brand, I. A., Müller, M. K., Unger, C., Söling, H. D.: In vivo and in vitro interconversions of active and inactive forms of phosphofructokinase in rat liver. FEBS Letters 68, 271–274 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Soboll, S., Scholz, R., Heldt, H.: Subcellular Metabolite Concentrations. Europ. J. Biochem. 87, 377–390 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Jungermann, K., Sasse, D.: Heterogeneity of liver parenchymal cells. Trends Biochem. Sci. 3, 198–202 (1978).

    Article  CAS  Google Scholar 

  • Riou, J. P., Claus, T. H., Pilkis, S. J.: Stimulation by Glucagon of In Vivo Phosphorylation of Rat Hepatic Pyruvate Kinase. J. biol. Chem. 253, 656–659 (1978).

    PubMed  CAS  Google Scholar 

  • Ekman, P., Dahlquist, U., Humble, E., Engström, L.: Comparative kinetic studies on the L-type pyruvate kinase from rat liver and the enzyme phosphorylated by 3′,5′-AMP-stimulated protein kinase. Biochim. Biophys. Acta (Amsterdam) 429, 374–382 (1976).

    CAS  Google Scholar 

Glykogenosen

  • Fernandes, K.: Hepatic glycogen storage diseases. In: The treatment of inherited metabolic disease (D. N. Raine, Ed.). Lancaster: MTP Press 1975.

    Google Scholar 

  • Steinitz, K.: Laboratory diagnosis of glycogen diseases. Advanc. clin. Chem. 9, 228–354 (1967).

    Google Scholar 

  • Cornblath, M., Schwartz, R.: Disorders of glycogen metabolism. In: Disorders of carbohydrate metabolism in infancy (A. J. Schaffer, Ed.). Philadelphia-London: Saunders 1966.

    Google Scholar 

  • Bickel, H., Bremer, H. J.: Störungen des Stoffwechsels. In: Lehrbuch der Kinderheilkunde, 4. Aufl. (A.Wiskott, K.Betke, W.Künzer, Eds.) S. 14.11–14.14. Stuttgart: Thieme 1977.

    Google Scholar 

Fettembolie

  • Sevitt, S.: Fat Embolism. J. Trauma 10, 1074–1077 (1970).

    Article  PubMed  Google Scholar 

  • Huth, K.: Fettstoffwechselveränderungen bei der experimentellen Fettembolie. Anaesthesiol. Wiederbeleb. 58, 96–98 (1971).

    Google Scholar 

  • Baltensweiler, J.: Prophylaxe der Fettembolie. Arch. Chir. 329, 517–518 (1972).

    Article  Google Scholar 

Diabetes mellitus

  • Labhart, A.: Klinik der Inneren Sekretion, 2. Aufl. Berlin-Heidelberg-New York: Springer 1971.

    Google Scholar 

  • Mehnert, H., Förster, H.: Stoffwechselkrankheiten — Biochemie und Klinik, 2. Aufl. Stuttgart: Thieme 1975.

    Google Scholar 

  • Mehnert, H., Schöffling, K.: Diabetologie in Klinik und Praxis. Stuttgart: Thieme 1974.

    Google Scholar 

  • Pfeiffer, E. F.: Handbuch des Diabetes mellitus, Band I: Pathophysiologie und Klinik. München: Lehmann 1968.

    Google Scholar 

  • Williams, R.: Textbook of endocrinology, 4. Ed. Philadelphia: Saunders 1968.

    Google Scholar 

  • Renold, A. E., Stauffacher, W., Cahill, G.: Diabetes mellitus. In: The Metabolic Basis of Inherited Disease, 3rd ed. (J. B. Stanbury, J. B. Wyngaarden, D. S. Fredrickson, Eds.), p. 83–118. New York: McGraw-Hill 1972.

    Google Scholar 

  • Weinges K. F.: Ist eine Neuorientierung der oralen Diabetesbehandlung nötig? Med. Welt 23, 949–962 (1972).

    PubMed  CAS  Google Scholar 

Störungen des Harnstoffcyclus

  • Colombo, J. B.: Congenital disorders of the urea cycle and ammonia detoxication. Basel: Karger 1971.

    Google Scholar 

  • Gerok, W.: Biochemische Befunde bei der Entstehung einer Hyperammoniämie. Anaesthesiol. Wiederbel. 13, 94 (1966).

    Google Scholar 

  • Szam, I.: Ammoniakstoffwechsel. Stuttgart: Schattauer 1972.

    Google Scholar 

Fettleber

  • Alpers, D. H., Isselbacher, K. J.: Fatty liver: Biochemical and clinical aspects. In: Diseases of the liver (L. Schiff, Ed.). Philadelphia: Lipincott 1975.

    Google Scholar 

  • Lieber, S.S.: Origin and pathogenesis of fatty acid accumulation in the liver during prolonged ethanol consumption. In: Metabolic changes induced by alcohol (G. A. Martini and Ch. Bode, Eds.). Berlin-Heidelberg-New York: Springer 1971.

    Google Scholar 

  • Gerok, W.: Pathogenese, Diagnose und Therapie der Fettleber. Med. Welt 24, 862 (1973).

    PubMed  CAS  Google Scholar 

Fettsucht (Überernährung)

  • Cahill, G. F., Owen, O. E., Morgan, A. P.: The consumption of fuels during prolonged starvation. Advanc. Enzyme Regulat. 6, 143 (1968).

    Article  CAS  Google Scholar 

  • Daweke, H., Haase, J., Irmscher, K.: Diätkatalog. Berlin-Heidelberg-New York: Springer 1976.

    Google Scholar 

  • Ditschuneit, H., Faulhaber, J.-D., Beil, Pfeiffer, E. F.: Veränderungen des Stoffwechsels bei Null-Diät. Internist (Berl.) 11, 176 (1970).

    CAS  Google Scholar 

  • Griess, F. A., Berchtold, P, Berger, M.: Adipositas. Pathophysiologie, Klinik und Therapie. Berlin-Heidelberg-New York: Springer 1976.

    Google Scholar 

  • Hadorn, W: Behandlungsmöglichkeiten der Fettsucht. Schweiz. med. Wschr. 84, 575 (1954).

    PubMed  CAS  Google Scholar 

  • Holtmeier, H.-J.: Diät bei Übergewicht und gesunde Ernährung, 4. überarbeitete Auflage, S. 10. Stuttgart: Thieme 1969.

    Google Scholar 

  • Kasper, H., Rabast, U.: Kritisches zur diätetischen Behandlung der Adipositas. Aktuelle Ernährungsmedizin 1, 5 (1976).

    Google Scholar 

  • Königsfeld, H.: Die Lebensdauer des Menschen. Lebensversicherungsmedizin 8, 43 (1976).

    Google Scholar 

  • Matzkies, F., Baumbauer, E., Pemsel, W., Kori-Lindner, C., Berg, G., Sailer, D., Grabner, W., Bergner, D.: Erfahrungen mit einer Minimalernährung zur ambulanten Behandlung des Übergewichts. Med. u. Ernähr. 13, 97 (1972).

    Google Scholar 

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Jungermann, K., Möhler, H. (1980). Verwertung der Energiespeicher und Energiegewinnung in der Postresorptionsphase. In: Biochemie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67258-3_6

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