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Molecular Probes and Genome Homology

  • Chapter
The Epstein-Barr Virus

Abstract

The Epstein-Barr Virus (EBV) offers a unique opportunity to put to test landmark concepts and technology advanced in experimental tumor virus systems in recent years. The principal concept resulting from exploration of the viral etiology of cancer is the demonstration that, at least in vitro, viral genes remain in the malignant cell after the initial infection of the normal progenitor cell. This concept has been elaborated so that we know that specific viral DNA sequences containing defined genes are integrated into the cellular genetic composition and that these viral genes are expressed in the malignant cell. This concept must occupy a central position in the elusive quest for proof of causation between virus and human cancer.

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Authors and Affiliations

  1. Department of Medicine, Cancer Research Center, School of Medicine, University of North Carolina, Chapel Hill, NC, 27514, USA

    J. S. Pagano & J. E. Shaw

  2. Department of Bacteriology, Cancer Research Center, School of Medicine, University of North Carolina, Chapel Hill, NC, 27514, USA

    J. S. Pagano & J. E. Shaw

  3. Department of Immunology, Cancer Research Center, School of Medicine, University of North Carolina, Chapel Hill, NC, 27514, USA

    J. S. Pagano & J. E. Shaw

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  1. J. S. Pagano
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  1. Department of Pathology, The Medical School, University of Bristol, University Walk, Bristol, BS8 1TD, England

    M. A. Epstein M.A., M.D., Ph.D., D.Sc., F.R.C. Path., F.R.S.  & B. G. Achong M.B., B.Ch., B.A.O., M.D.  & 

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Pagano, J.S., Shaw, J.E. (1979). Molecular Probes and Genome Homology. In: Epstein, M.A., Achong, B.G. (eds) The Epstein-Barr Virus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67236-1_6

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