EB Virus-Induced Antigens

  • I. Ernberg
  • G. Klein


The study of antigenic markers and antibodies directed against them has occupied a central position in all Epstein-Barr virus (EBV) research, ever since the discovery of the virus. Detailed seroepidemiologic studies on the distribution and pathogenic significance of virus infections, retrospective and prognostic studies on patients with EBV-related diseases, and tracing of early events during primary viral infection of normal cells in vitro are only some of the areas that were largely or entirely based on antigen-antibody tests. Serology played a primary role in establishing the relationship between the virus and the three EBV-related diseases: infectious mononucleosis (IM), Burkitt’s lymphoma (BL), and nasopharyngeal carcinoma (NPC). Furthermore, the majority of viral infectivity assays are based on antigen induction in appropriate target cells.


Nuclear Antigen Raji Cell Early Antigen Viral Capsid Antigen Viral Cycle 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1979

Authors and Affiliations

  • I. Ernberg
    • 1
  • G. Klein
    • 1
  1. 1.Department of Tumor BiologyKarolinska InstitutetStockholm 60Sweden

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